Cited by Relevance of Circulating microRNA, and their Association with Islet Cell Autoantibodies in Type 1 Diabetes Pathogenesis

Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study DOI

Chaozhong Li, Zhengqing Liu,

Siqian Yang

et al.

Clinical and Experimental Hypertension, Journal Year: 2024, Volume and Issue: 46(1)

Published: Aug. 12, 2024

Background Complex interconnections are evident among gut microbiota, circulating metabolites, inflammatory cytokines, and the pathogenesis of abdominal aortic aneurysms (AAA), with causal dynamics yet to be comprehensively elucidated. The primary objective this study was elucidate potential relationships involving microbiota-mediated plasma AAA.

Language: Английский

Citations

How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation DOI

C A Wells,

T. A. Robertson,

Prameet M. Sheth

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32831 - e32831

Published: June 1, 2024

The gut microbiome has come to prominence across research disciplines, due its influence on major biological systems within humans. Recently, a relationship between the and hematopoietic system been identified coined gut-bone marrow axis. It is well established that separately alter with age; however, these changes how each other demands investigation. Since produces immune cells help govern commensal bacteria, it important identify interacts stem (HSCs). microbiota shown development outcomes of hematologic disorders, suggesting dysbiosis may maintenance HSCs age. Short chain fatty acids (SCFAs), lactate, iron availability, tryptophan metabolites, bacterial extracellular vesicles, microbe associated molecular patterns (MAMPs), toll-like receptor (TLR) signalling have proposed as key mediators communication axis will be reviewed in this article context aging.

Language: Английский

Citations

Identification of biomarkers in multiple myeloma: A comprehensive study combining microarray analysis and Mendelian randomization DOI

Yidong Zhu, Jun Liu, Bo Wang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(12)

Published: June 1, 2024

Despite remarkable advancements in the treatment of multiple myeloma (MM), relapse remains a challenge. However, mechanisms underlying this disease remain unclear. This study aimed to identify potential biomarkers that could open new avenues for MM treatment. Microarray data and clinical characteristics patients with were obtained from Gene Expression Omnibus database. Differential expression analysis protein-protein interaction (PPI) network construction used hub genes associated MM. Predictive performance was further assessed using receiver operating characteristic curves nomogram construction. Functional enrichment conducted investigate possible mechanisms. Mendelian randomization (MR) evaluate causal relationship between crucial gene risk. Topological PPI revealed five MM, myeloperoxidase (MPO) being key owing its highest degree area under curve values. MPO showed significant differences controls across all datasets. strong association immune-related pathways MR confirmed risk By integrating microarray MR, we successfully identified validated as promising biomarker is potentially implicated pathogenesis progression through pathways.

Language: Английский

Citations

Relevance of Circulating microRNA, and their Association with Islet Cell Autoantibodies in Type 1 Diabetes Pathogenesis DOI

Aritânia Sousa Santos, Daniele Pereira Santos‐Bezerra, Ludmila Rodrigues Pinto Ferreira

et al.

Archives of Medical Research, Journal Year: 2024, Volume and Issue: 56(2), P. 103114 - 103114

Published: Nov. 2, 2024

Language: Английский

Citations