Expert Review of Anti-infective Therapy, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 13, 2024
The increase of antibiotic resistance, together with the absence novel antibiotics, makes mandatory introduction strategies to optimize use existing antibiotics. Among them, molecules that their activity looks promising.
Language: Английский
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Language: Английский
Citations
1
Environmental Science and Ecotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 100557 - 100557
Published: March 1, 2025
The widespread and indiscriminate use of biocides poses significant threats to global health, socioeconomic development, environmental sustainability by accelerating antibiotic resistance. Bacterial resistance development is highly complex influenced significantly factors. Increased biocide usage in households, agriculture, livestock farming, industrial settings, hospitals produces persistent chemical residues that pollute soil aquatic environments. Such contaminants contribute the selection proliferation resistant bacteria antimicrobial genes (ARGs), facilitating their dissemination among humans, animals, ecosystems. In this review, we conduct a critical assessment four issues pertaining topic. Specifically, (i) role exerting selective pressure within resistome, thereby promoting microbial populations contributing spread (ARGs); (ii) triggering transient phenotypic adaptations bacteria, including efflux pump overexpression, membrane alterations, reduced porin expression, which often result cross-resistance multiple antibiotics; (iii) capacity disrupt make genetic content accessible, releasing DNA into environment remains intact under certain conditions, horizontal gene transfer determinants; (iv) bacterial cells, enhancing interactions between biofilms environment, strengthening biofilm cohesion, inducing mechanisms, creating reservoirs for microorganisms ARG dissemination. Collectively, review highlights public health implications use, emphasizing an urgent need strategic interventions mitigate proliferation.
Language: Английский
Citations
1
Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 183 - 183
Published: Feb. 11, 2025
Background/Objectives: Antimicrobial-resistant Staphylococcus aureus is a growing threat to human health for which alternative therapeutic options are needed. In this study, we aimed evaluate the efficacy of amlodipine (AML) and imipramine (IMI) treat S. infection in Galleria mellonella larval model by targeting efflux biofilms, relevant contributors antimicrobial resistance virulence aureus. Methods: In-house reared G. were used assays determine infective dose two strains differing expression norA (gene encoding native NorA pump). Toxicology conducted drugs' LD50 mellonella. Drug performed potential amlodipine, control drugs ciprofloxacin (CIP) enalapril (ENA) clear Results: Survival analysis defined as 1 × 107 CFU/larva both strains. High values determined (CIP: >1000 mg/kg; AML: >640 IMI: 1141 ENA: >1280 mg/kg), revealing high tolerance these drugs. AML at 15 mg/kg IMI 100 increased larvae survival 20% (p = 0.04) 11% 0.11), respectively, also positively affecting score indexes. agreement with literature, >100 promoted >73%. Conclusions: Amlodipine show mild new managing infections but promising lead molecules. This study reinforces sustainable, reliable drug evaluation.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119737 - 119737
Published: April 1, 2025
Language: Английский
Citations
0
Processes, Journal Year: 2025, Volume and Issue: 13(5), P. 1270 - 1270
Published: April 22, 2025
Biofilms formation by the Burkholderia cepacia complex (Bcc) poses a considerable risk to hospital environments, particularly for immunocompromised individuals. These bacteria exhibit notable resistance disinfectants and antibiotics, mainly due their ability adhere biotic abiotic surfaces, forming highly persistent biofilms, contamination, pharmaceutical solutions. microbial structures function as protective shields, impeding effective action of antimicrobial compounds facilitating occurrence chronic infections outbreaks in healthcare settings. The high genetic plasticity Bcc, evidenced presence multiple chromosomes ease horizontal gene transfer, further enhances its capacity adaptation treatment resistance. Moreover, Bcc survive aquatic environments withstand unfavorable conditions heightens concerns regarding contamination products. This study examines molecular mechanisms underlying biofilm formation, impact on infections, challenges associated with eradication. It also discusses current detection techniques available innovative approaches mitigating In summary, thorough understanding maintenance is crucial implementing more preventive measures minimizing risks infections.
Language: Английский
Citations
0
Antibiotics, Journal Year: 2024, Volume and Issue: 13(10), P. 929 - 929
Published: Sept. 29, 2024
Bacteria have evolved and continue to change in response environmental stressors including antibiotics. Antibiotic resistance the ability form biofilms are inextricably linked, requiring continuous search for alternative compounds antibiotics that affect biofilm formation. One of latest drug classes is boron-containing compounds. Over last several decades, boron has emerged as a prominent element field medicinal chemistry, which led an increasing number being considered potential drugs. The focus this review on developments organic (BOCs) antimicrobial/anti-biofilm probes agents.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12222 - 12222
Published: Nov. 14, 2024
Helicobacter pylori is a major pathogen associated with various gastric diseases. Despite decades of research, the treatment H. remains challenging. One primary mechanisms contributing to failures therapies targeting this bacterium genetic mutations in drug target sites, although growing body scientific data highlights that efflux pumps may also take part process. Efflux are proteinaceous transporters actively expelling antimicrobial agents from interior targeted cells and reducing intracellular concentration these compounds. Considering contribute both resistance biofilm formation, an in-depth understanding their properties constitute cornerstone development novel therapeutics against pylori. In line this, aim current review describe multitude produced by present describing involvement proteins tolerance and/or classes substances.
Language: Английский
Citations
1
Journal of Medical Microbiology, Journal Year: 2024, Volume and Issue: 73(8)
Published: Aug. 30, 2024
is an ESKAPE pathogen and threatens human health by generating infections with high fatality rates.
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Oct. 14, 2024
Addressing the global antimicrobial resistance (AMR) crisis requires a multifaceted innovative approach to mitigate impacts on public health, healthcare and economic systems. In complex evolution of AMR, biofilms acquisition genes (ARGs) play pivotal role. Aeromonas is major AMR player that often forms biofilm, harbors ARGs frequently detected in wastewater. Existing wastewater treatment plants (WWTPs) do not have capacity totally eliminate antimicrobial-resistant bacteria favoring Besides facilitating emergence contribute significantly biofouling process within activated sludge WWTP bioreactors. This paper presents inhibition biofilm formation, expression biofilm-linked by phytochemicals andrographolide, docosanol, lanosterol, quercetin, rutin thymohydroquinone. species were isolated purified from samples. The s pecies through PCR. quantified following application biocompounds microtiter plate assay. qPCR analyses related done for confirmation. Findings showed natural compounds inhibited formation reduced linked production as well . indicates efficacy these targeting controlling both highlighting their potential solutions combating biofouling.
Language: Английский
Citations
0
Gene, Journal Year: 2024, Volume and Issue: unknown, P. 149105 - 149105
Published: Nov. 1, 2024
Language: Английский
Citations
0