Exploring the Causal Relationship Between Gut Microbiota and Pulmonary Artery Hypertension: Insights From Mendelian Randomization

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Background Research into the “gut–lung” axis links gut microbiota to pulmonary artery hypertension (PAH). However, mechanisms by which influence PAH remain unclear. We aimed investigate causal relationship between and using Mendelian randomization analysis, identify key metabolites, explore regulatory role of associated genes in pathogenesis. Methods Results examined association taxa inverse variance weighted 2‐sample randomization–Egger, median, mode methods. Additionally, we identified PAH‐regulating intestinal microbiome bioinformatics tools validated their expression levels lung tissue hypoxia‐induced mice models quantitative reverse transcription polymerase chain reaction. Eleven were with PAH. The order Clostridiales genera Eubacterium fissicatena group, Lachnospiraceae UCG004 , Ruminococcaceae UCG002 positively PAH, whereas Bifidobacteriales; family Bifidobacteriaceae; eligens group Sutterella, Methanobrevibacter Sellimonas Tyzzerella3 negatively some exhibiting bidirectional causality. These modulate 24 including palmitoylcholine, oleoylcholine, 3,7‐dimethylurate, Hypoxia‐induced had significantly downregulated 1,4,5‐trisphosphate receptor type 2, degrading enzyme, nuclear receptor‐interacting protein 1, growth factor‐binding 1 tissues, indicating potential regulation. Conclusions findings suggest that composition metabolites contribute development regulating gene expression. Our have implications for advancing microbiota‐based diagnostic technologies targeted therapies.

Language: Английский

Genetic prediction of the effect of gut microbiota on uveitis via blood metabolites: A mediated Mendelian randomization investigation

Medicine, Journal Year: 2024, Volume and Issue: 103(50), P. e40922 - e40922

Published: Dec. 13, 2024

The gut microbiota (GM) may be associated with uveitis. However, the causal relationship between GM and uveitis whether blood metabolites act as mediators of remain unclear. We extracted GM, metabolites, data from genome-wide association study (GWAS) summary data. used Mendelian randomization (MR) to investigate relationships among primary statistical method was inverse variance weighted (IVW) method. In addition, we 2-sample MR, bidirectional 2-step multiple MR explore were After removing confounding factors, abundances order Bacillales genus Holdemanella are risk factors for uveitis, Peptococcus Ruminococcaceae UCG010 protective factors. analysis revealed that affected 6 taxa – 4 positively 2 negatively. N-methyl proline 2-hydroxy sebacate identified N-formy1 phenylalanine, 1-ribosyl-imidazole acetate, 1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) alpha-ketoglutarate/pyruvate Finally, there a 3 positive negative effects. N-methylproline possessed greatest mediated effect (9.41%) These results provide new insights into pathogenesis offer approach prevention treatment perspective.

Language: Английский

When the Heart Catches Us Unawares: A Rare Case of Right-Sided Endocarditis Caused by Alistipes Onderdonkii

Annals of Case Reports, Journal Year: 2024, Volume and Issue: 9(3)

Published: May 28, 2024

Right-sided infective endocarditis, which accounts for 5-10% of cases, mainly affects the tricuspid valve and is frequently associated with use drugs, intracardiac devices, or venous catheters. The germs most often identified are staphylococci, streptococci, enterococci. Gut microbiota lives in gastrointestinal tract main coexist harmoniously humans. Bacteria predominant component gut microbiome, but viruses, fungi, archaea also present influence systemic metabolism. Scientists have confirmed that microbes closely related to human health by regulating metabolism immune function. Research has established crucial role function, yet association between endocarditis remains underexplored. Here, we report first documented case right-sided caused Alistipes onderdonkii.

Language: Английский