Gut microbiome composition in patients with liver cirrhosis with and without hepatic encephalopathy: A systematic review and meta-analysis

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 6, 2025

The gut microbiome is associated with hepatic encephalopathy (HE), but research results on the characteristics of patients liver cirrhosis and without HE are inconsistent. To study microbiota HE. We searched PubMed, Web Science, EMBASE, Cochrane databases using two keywords, HE, microbiome. According to inclusion exclusion criteria, suitable literature was screened extract data diversity composition fecal in were analyzed RevMan STATA. Seventeen studies included: (1) A meta-analysis 7 revealed that Shannon index significantly lower than [-0.20, 95% confidence interval (CI): -0.28 -0.13, I2 = 20%]; (2) relative abundances Lachnospiraceae (-2.73, 95%CI: -4.58 -0.87, 38%) Ruminococcaceae (-2.93, -4.29 -1.56, 0%) those HE; (3) In Enterococcus, Proteobacteria, Enterococcaceae, Enterobacteriaceae proportions increased, Ruminococcaceae, Lachnospiraceae, Prevotellaceae, Bacteroidetes decreased; (4) Differences metabolome between detected; (5) Differential microbiomes may serve as diagnostic prognostic tools. differ. Some distinguish or determine patient prognosis.

Language: Английский

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Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012–2023)

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Polycystic ovary syndrome (PCOS) is a common gynecological condition affecting individuals of reproductive age and linked to the gut microbiome. This study aimed identify hotspots research trends within domain microbiome in PCOS through bibliometric analysis. Utilizing techniques, we examined literature on from Web Science Core Collection spanning period 2012 2023. Analytical tools such as CiteSpace, VOSviewer, Bibliometric R packages were employed evaluate various metrics, including countries/regions, institutions, authors, co-cited authors' H-index, journals, co-references, keywords. A total 191 publications identified field PCOS, with an increase annual 2018 People's Republic China was most productive country, followed by United States America (USA), India. Shanghai Jiao Tong University, Fudan Beijing University Chinese Medicine top three institutions. Thackray VG prolific author, holding highest while Liu received number citations. The journal "Frontiers Endocrinology" published articles this domain. frequently reference authored Qi XY. analysis keyword burst detection "bile acids" (2021-2023) leading frontier keyword. Additionally, "gut dysbiosis," "phenotypes," "adolescents," "metabolomics," "metabolites," "fecal microbiota transplantation," "IL-22" have emerged primary keywords reflecting recent trends. explores how influences endocrine metabolic disorders related emphasizing its role development treatments targeting findings serve valuable resource for researchers, enabling them critical emerging areas investigation field.

Language: Английский

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Global trends in migraine and anxiety over the past 10 years: a bibliometric analysis

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 22, 2025

Background Recent studies have shown that migraine significantly increases the incidence of anxiety and is positively correlated with severity frequency migraine. The relationship between has attracted extensive attention. This study focused on association anxiety, aiming to predict potential future research trends. Methods A bibliometric analysis was conducted using publications from Core Collection Web Science. We utilized CiteSpace.5.8.R3 VOSviewer 1.6.17 evaluate value articles over past 10 years. Results number increased cooperative network shows United States most collaborative country. Additionally, Harvard University institution Richard B. Lipton individual highest keyword outbreaks indicates strong citation burst words are closely related sex differences, activation, allodynia, preventive treatment, which represent emerging new areas hotspots for research. Conclusion An overall upward trend in observed. Sex functional magnetic resonance imaging (fMRI), treatment predicted be future.

Language: Английский

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Advances in intrahepatic and extrahepatic vascular dysregulations in cirrhotic portal hypertension

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 31, 2025

Cirrhotic portal hypertension, the most prevalent and clinically significant complication of liver cirrhosis, manifests as elevated venous pressure is associated with severe complications. Although much research on mechanisms hypertension has focused fibrosis, less attention been given to role intrahepatic extrahepatic vascular dysfunction, particularly respect vasculature. While hepatic fibrosis in cirrhotic undeniable, underlying involving vasculature are highly complex. Sinusoidal capillarization endothelial dysfunction contribute increased resistance. Hemodynamic changes circulation, including splanchnic vasodilation hyperdynamic play a development hypertension. Additionally, therapeutic strategies targeting these diverse, improvement sinusoidal microcirculation, therapies stellate cells activation, pharmacological modulation systemic tone. Therefore, this review, we will discuss vascular-related treatment progress cirrhosis provide new theoretical basis practical guidance for clinical treatment.

Language: Английский

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Hepatic encephalopathy treatment after transjugular intrahepatic portosystemic shunt: a new perspective on the gut microbiota

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 7, 2025

Transjugular intrahepatic portosystemic shunt (TIPS) placement alleviates portal hypertension symptoms. Hepatic encephalopathy (HE) is a common complication of TIPS, impacting patient quality life and the healthcare burden. Post-TIPS HE associated with shunting, elevated blood ammonia levels, inflammation. Increasing attention has been given to liver intestinal circulation in recent years. An imbalance microecology plays role occurrence may be new target for treatment. This review discusses causes, diagnosis, treatment strategies post-TIPS focuses on exploring their relationships gut microbiota, suggesting an innovative approach address this complication.

Language: Английский

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Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.

Language: Английский

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Mapping Data-Driven Research Impact Science: The Role of Machine Learning and Artificial Intelligence

Metrics, Journal Year: 2025, Volume and Issue: 2(2), P. 5 - 5

Published: April 2, 2025

In an era of evolving scholarly ecosystems, machine learning (ML) and artificial intelligence (AI) have become pivotal in advancing research impact analysis. Despite their transformative potential, the fragmented body literature this domain necessitates consolidation to provide a comprehensive understanding applications multidimensional assessment. This study bridges gap by employing bibliometric methodologies, including co-authorship analysis, citation burst detection, advanced topic modelling using BERTopic, analyse curated corpus 1608 articles. Guided three core questions, investigates how ML AI enhance evaluation, identifies dominant outlines future directions. The findings underscore potential augment traditional indicators uncovering latent patterns collaboration networks, institutional influence, knowledge dissemination. particular, scalability semantic depth BERTopic thematic extraction, combined with visualisation capabilities tools such as CiteSpace VOSviewer, novel insights into dynamic interplay contributions across dimensions. Theoretically, extends scientometric discourse integrating computational techniques reconfiguring established paradigms for assessing contributions. Practically, it provides actionable researchers, institutions, policymakers, enabling enhanced strategic decision-making visibility impactful research. By proposing robust, data-driven framework, lays groundwork holistic equitable addressing its academic, societal, economic

Language: Английский

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Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance: A visualization and bibliometric study

World Journal of Hepatology, Journal Year: 2024, Volume and Issue: 16(6), P. 951 - 965

Published: June 19, 2024

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a condition that prevalent worldwide and associated with significant health risks economic burdens. As it has been linked to insulin resistance (IR), this study aimed perform bibliometric analysis visually represent the scientific literature on IR NAFLD. AIM To map research landscape underscore critical areas of focus, influential studies, future directions NAFLD IR. METHODS This conducted indexed in SciVerse Scopus database from 1999 2022. The search strategy used terms medical subject headings, focusing related VOSviewer software was visualize trends, collaborations, key thematic areas. examined publication type, annual output, contributing countries institutions, funding agencies, journal impact factors, citation patterns, highly cited references. RESULTS identified 23124 documents NAFLD, revealing increase number publications between retrieved 715 papers including 573 (80.14%) articles 88 (12.31%) reviews. most productive were China (n = 134; 18.74%), United States 122; 17.06%), Italy 97; 13.57%), Japan 41; 5.73%). leading institutions included Università degli Studi di Torino, 29; 4.06%), Consiglio Nazionale delle Ricerche, 19; 2.66%). top agencies National Institute Diabetes Digestive Kidney Diseases 48; 6.71%), Natural Science Foundation 37; 5.17%). active journals field Hepatology (27 publications), Journal (17 Clinical Endocrinology Metabolism (13 publications). main hotspots “therapeutic approaches for NAFLD” “inflammatory high-fat diet impacts NAFLD”. CONCLUSION first examine relationship In response escalating global challenge highlights an urgent need better understanding development intervention strategies. Policymakers prioritize address increasing prevalence

Language: Английский

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Gut microbiota, circulating inflammatory proteins, and cirrhosis: a multivariable Mendelian randomization study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Background The liver-gut axis is the focal point of cirrhosis research, suggesting a close association between gut microbiota (GM) and cirrhosis. Previous studies have shown significant correlation changes in microbial composition. There was severity compared to healthy individuals, displacement specific GM, number invading microorganisms. However, causal relationship GM whether inflammatory proteins play mediating role remain unclear. Therefore, it necessary explore specificity GMs associated with their underlying mechanisms for subsequent risk prediction, treatment, prognosis patients Methods We identified genetic variants closely circulating proteins, from large-scale genome-wide (GWAS) summary data explored three mediate GM-to-cirrhosis pathway using multivariate Mendelian randomization. This study used inverse variance weighting (IVW) method MR-Egger as primary methods, supplemented by weighted median estimator (WME), Weighted model, Simple model. Results were four positive negative results five In addition, Tumor necrosis factor ligand superfamily member 12 (TNFSF12) may Genus Ruminococcus torques-cirrhosis pathway.

Language: Английский

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