Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 19, 2024
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422
Published: Feb. 10, 2025
The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.
Language: Английский
Citations
1
Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 599 - 599
Published: March 5, 2025
Microbial engineering has made a significant breakthrough in pharmaceutical biotechnology, greatly expanding the production of biologically active compounds, therapeutic proteins, and novel drug candidates. Recent advancements genetic engineering, synthetic biology, adaptive evolution have contributed to optimization microbial strains for applications, playing crucial role enhancing their productivity stability. The CRISPR-Cas system is widely utilized as precise genome modification tool, enabling enhancement metabolite biosynthesis activation biological pathways. Additionally, biology approaches allow targeted design microorganisms with improved metabolic efficiency potential, thereby accelerating development new products. integration artificial intelligence (AI) machine learning (ML) plays vital further advancing by predicting network interactions, optimizing bioprocesses, discovery process. However, challenges such efficient pathways, ensuring sustainable industrial-scale production, meeting international regulatory requirements remain critical barriers field. Furthermore, mitigate potential risks, it essential develop stringent biocontainment strategies implement appropriate oversight. This review comprehensively examines recent innovations analyzing key technological advancements, challenges, future perspectives.
Language: Английский
Citations
1
Methods in microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 250 - 250
Published: Jan. 23, 2025
Erectile dysfunction (ED) is a prevalent male sexual disorder characterized by the persistent inability to achieve or maintain an erection sufficient for satisfactory performance. While its etiology multifactorial, encompassing vascular, neurological, hormonal, and psychological components, emerging evidence suggests significant role gut microbiota dysbiosis in development. The influences various metabolic, inflammatory, neuropsychological processes critical erectile function. Dysbiosis can lead systemic inflammation, endothelial dysfunction, hormonal imbalances, altered neurotransmitter production, all of which are key factors ED pathogenesis. This narrative review synthesizes current research on association between alterations ED, highlighting specific bacterial taxa implicated through mechanisms involving metabolic disturbances, regulation. explores potential linking including pro-inflammatory cytokines, barrier integrity disruption, disorders, via gut–brain axis, Furthermore, offers promising avenues developing non-invasive biomarkers therapeutic interventions such as probiotics, prebiotics, dietary modifications, fecal transplantation. Future should focus longitudinal studies, mechanistic explorations, clinical trials validate these findings translate them into practice. Understanding interplay function could unveil novel diagnostic pave way innovative treatments targeting microbiota, ultimately improving men’s overall health.
Language: Английский
Citations
0
Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144047 - 144047
Published: March 1, 2025
Language: Английский
Citations
0
Current Plant Biology, Journal Year: 2025, Volume and Issue: unknown, P. 100478 - 100478
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Bioinformatics, Journal Year: 2025, Volume and Issue: 5
Published: April 9, 2025
Microbiome research is becoming a mature field with wealth of data amassed from diverse ecosystems, yet the ability to fully leverage multi-omics for reuse remains challenging. To provide view into researchers' behavior and attitudes towards reuse, we surveyed over 700 microbiome researchers evaluate sharing challenges. We found that many are impeded by difficulties metadata records, challenges processing bioinformatics, problems repository submissions. also explored cost constraints at each step process better understand "pain points" more quantitative perspective sixteen active researchers. The bioinformatics was estimated be most time consuming, which aligns some frequently reported community survey. From these two approaches, present evidence-based recommendations how address concrete actions future work.
Language: Английский
Citations
0
Frontiers in Medical Technology, Journal Year: 2025, Volume and Issue: 6
Published: April 15, 2025
The microbiome of the gut is a complex ecosystem that contains wide variety microbial species and functional capabilities. has significant impact on health disease by affecting endocrinology, physiology, neurology. It can change progression certain diseases enhance treatment responses tolerance. microbiota plays pivotal role in human health, influencing range physiological processes. Recent advances computational tools artificial intelligence (AI) have revolutionized study microbiota, enabling identification biomarkers are critical for diagnosing treating various diseases. This review hunts through cutting-edge methodologies integrate multi-omics data—such as metagenomics, metaproteomics, metabolomics—providing comprehensive understanding microbiome's composition function. Additionally, machine learning (ML) approaches, including deep network-based methods, explored their ability to uncover patterns within data, offering unprecedented insights into interactions link host health. By highlighting synergy between traditional bioinformatics advanced AI techniques, this underscores potential these approaches enhancing biomarker discovery developing personalized therapeutic strategies. convergence advancements research marks step forward precision medicine, paving way novel diagnostics treatments tailored individual profiles. Investigators discover connections microorganisms, expression genes, profiles metabolites. Individual reactions medicines target microbes be predicted models driven intelligence. possible obtain medicine first gaining an development disease. application allows customization specific environment individual.
Language: Английский
Citations
0
International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(8), P. 1235 - 1247
Published: Aug. 1, 2024
Language: Английский
Citations
3