Molecular mechanisms and therapeutic strategies of gut microbiota modulation in Sarcopenia (Review) DOI Open Access
Chengfu Yuan

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(3)

Published: Dec. 17, 2024

Sarcopenia is an age-related disease that characterized by a decline in muscle mass and function with significant epidemiological clinical implications. In recent years, gut microbiota has gained attention as important regulatory factor human health. To the best of our knowledge, this first study to introduce definition background sarcopenia analyze potential impact on metabolism growth, including aspects such metabolites, protein synthesis energy metabolism. Additionally, article summarizes current research progress interventions for treatment sarcopenia, probiotics, prebiotics fecal transplantation discusses future directions therapeutic strategies.

Language: Английский

Effects of Chicken Protein Hydrolysate as a Protein Source to Partially Replace Chicken Meal on Gut Health, Gut Microbial Structure, and Metabolite Composition in Cats DOI Creative Commons
Tong Yu,

Florence Humbert,

Dan Li

et al.

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(4), P. 388 - 388

Published: April 21, 2025

Protein hydrolysates positively affect intestinal function in both humans and animals, but their impact on gut health the microbial profile cats has not been thoroughly investigated. In this study, a total of 30 adult were randomly assigned to one three dietary treatments for 60-day feeding trial. The as follows: (1) basal diet (CON), (2) containing 15% powdered chicken protein hydrolysate (HP15%), (3) liquid (HL15%). Compared CON group, HP15% group had decreased calprotectin levels fecal gases emissions (p < 0.05). A higher abundance Bacteroidota, Veillonellaceae, Bacteroidaceae, while lower Firmicutes was showed HL15% than that At genus level, compared with an increased Bacteroides spp. Bifidobacterium showed, whereas reduced Alloprevotella presented groups metabolomic analysis revealed 1405 distinct metabolites between 0.05, VIP-pred-OPLS-DA > 1), level cholic acid isodeoxycholic 1910 4-coumaryl alcohol enterolactone summary, study suggested partially replacing meat helps regulate community metabolite improves health.

Language: Английский

Citations

0

Gut Microbiota Comparison in Rectal Swabs Versus Stool Samples in Cats with Kidney Stones DOI Creative Commons
Patrick Joubran, Françoise Roux, Matteo Sérino

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2411 - 2411

Published: Nov. 24, 2024

To investigate the role of intestinal bacterial microbiota in pathogenesis calcium oxalate nephrolithiasis cats, a condition characterized by formation kidney stones, it is desirable to identify sample collection method that accurately reflects microbiota’s composition. The objective this study was evaluate impact fecal methods on composition two cat populations: healthy cats and stone-diseased cats. included eighteen from same colony, comprising nine with spontaneously occurring presumed stones. Three were compared: rectal swabs, fresh stool, stool exposed ambient air for 24 h. analyzed through high-resolution sequencing V3–V4 region 16S rRNA gene. For all within individual, one-way PERMANOVA analysis showed significant difference between swabs (p = 0.0003), as well h but no identified non-fresh 0.0651). When comparing populations provides seemingly conflicting results. (1) A principal component (PCA) comparison revealed stones only when 0.0037). This finding suggests bacteria involved are luminal strictly anaerobic bacteria. Consequently, exposure results loss information, preventing identification dysbiosis. clinical studies, samples provided owners does not appear suitable studying gut stones; should be favored. (2) Interestingly, alone highlighted differences proportion major phyla populations. These findings highlight critical importance carefully selecting feline microbiota. Combining sampling complementary insights, offering most accurate understanding context stone pathogenesis.

Language: Английский

Citations

0

Molecular mechanisms and therapeutic strategies of gut microbiota modulation in Sarcopenia (Review) DOI Open Access
Chengfu Yuan

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(3)

Published: Dec. 17, 2024

Sarcopenia is an age-related disease that characterized by a decline in muscle mass and function with significant epidemiological clinical implications. In recent years, gut microbiota has gained attention as important regulatory factor human health. To the best of our knowledge, this first study to introduce definition background sarcopenia analyze potential impact on metabolism growth, including aspects such metabolites, protein synthesis energy metabolism. Additionally, article summarizes current research progress interventions for treatment sarcopenia, probiotics, prebiotics fecal transplantation discusses future directions therapeutic strategies.

Language: Английский

Citations

0