Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer DOI Creative Commons
Yao Yu,

Leqian Li,

Qishen Yang

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1653 - 1653

Published: Aug. 12, 2024

Prostate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses castration-resistant prostate (CRPC) with a poor prognosis. This study indicated that some PCa patients mice were more ADT entered CRPC later, which was related the gut microbiota, especially enrichment of Akkermansia muciniphila (AKK). Untargeted metabolomics analysis found serum inosine level upregulated in treatment-sensitive group significantly correlated AKK. Furthermore, we revealed intestinal permeability lipopolysaccharide (LPS) levels increased treatment-resistant mice. LPS stimulated upregulation p-NF-κB p65 AR tumors. Supplementing AKK metabolite could alleviate barrier damage reduce level, inhibiting castration via LPS/NF-κB/AR axis. Finally, constructed predictive model for combining microbiota clinical information (AUC = 0.729). potential mechanism on provided therapeutic targets prognostic indicators.

Language: Английский

Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma DOI Creative Commons
Yanguang Yang, Xinli Shi

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving

Language: Английский

Citations

1
Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy DOI Creative Commons
Yuqing Liu,

Fan Li,

Juanjuan Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: March 7, 2025

Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis development of tumor. The needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with improved survival outcomes many cancers. In recent years, increasing attention on the TLS tumor microenvironment, TLSs have emerged a novel target for anti-tumor therapy. Excitingly, studies shown contribution to immune responses. However, it unclear how form more effectively defense against through formation. Recent that inflammation plays role Interestingly, also found gut microbiota can regulate occurrence inflammation. Therefore, we here summarize potential effects microbiota- mediated or immunosuppression formation environments. Meanwhile, this review explores manipulate mature regulating microbiota/metabolites associated signal pathways potentially lead next-generation cancer immunotherapy.

Language: Английский

Citations

1
Alcohol-associated liver disease: Emerging therapeutic strategies DOI
Benjamin H. Mullish, Mark Thursz

Hepatology, Journal Year: 2024, Volume and Issue: 80(6), P. 1372 - 1389

Published: June 26, 2024

The large and growing burden of alcohol-associated liver disease—and the considerable morbidity mortality associated with it—has been a drive toward ongoing research into novel strategies for its treatment, particular focus upon hepatitis (AH). Management alcohol-use disorder forms central pillar disease care, evidence-based psychological pharmacological approaches being well established, certain models demonstrating improved clinical outcomes when hepatology addiction services are co-located. Corticosteroids have previously used somewhat indiscriminately in patients severe AH, but effective tools now exist to assess early response (and limit futile exposure). Techniques predict risk corticosteroid-related infection also available, although current mitigate this limited. A variety therapeutic AH at different phases trials evidence gathering, some most promising signals related cytokine manipulation, epigenetic modulation, targeting gut microbiota (ie, by means fecal transplant). While remaining an source debate, transplant has grown interest acceptability over past decade as supporting efficacy builds, process challenging paradigms about mandatory pretransplant sobriety periods. However, uncertainty remains regarding optimal selection criteria, whether role only highly limited proportion or more widespread application. This review aims provide overview fast-moving field.

Language: Английский

Citations

3
Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer DOI Creative Commons
Yao Yu,

Leqian Li,

Qishen Yang

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1653 - 1653

Published: Aug. 12, 2024

Prostate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses castration-resistant prostate (CRPC) with a poor prognosis. This study indicated that some PCa patients mice were more ADT entered CRPC later, which was related the gut microbiota, especially enrichment of Akkermansia muciniphila (AKK). Untargeted metabolomics analysis found serum inosine level upregulated in treatment-sensitive group significantly correlated AKK. Furthermore, we revealed intestinal permeability lipopolysaccharide (LPS) levels increased treatment-resistant mice. LPS stimulated upregulation p-NF-κB p65 AR tumors. Supplementing AKK metabolite could alleviate barrier damage reduce level, inhibiting castration via LPS/NF-κB/AR axis. Finally, constructed predictive model for combining microbiota clinical information (AUC = 0.729). potential mechanism on provided therapeutic targets prognostic indicators.

Language: Английский

Citations

0