The Influence of the Gut Microbiota on Host Health: A Focus on the Gut–Lung Axis and Therapeutic Approaches
Life,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1279 - 1279
Published: Oct. 9, 2024
The
human
gut
microbiota
is
a
complex
ecosystem
harboring
thousands
of
microbial
strains
that
play
crucial
role
in
maintaining
the
overall
well-being
its
host.
composition
varies
with
age
from
infancy
to
adulthood
and
influenced
by
dietary
habits,
environment,
genetic
disposition.
Recent
advances
culture-independent
techniques
nucleic
acid
sequencing
have
improved
our
understanding
diversity
microbiota.
species
present
release
short-chain
fatty
acids
(SCFAs),
which
anti-inflammatory
properties.
also
plays
substantial
modulating
host's
immune
system,
promoting
tolerance,
homeostasis.
impact
on
health
host
quite
evident,
as
dysbiosis
has
been
linked
various
diseases,
including
metabolic
disorders,
autoimmune
allergies,
inflammatory
bowel
diseases.
bidirectional
communication
respiratory
creating
gut-lung
axis,
associated
different
Therapeutic
approaches
targeting
microbiota,
such
probiotics,
prebiotics,
interventions,
fecal
transplantation
(FMT),
aim
restore
balance
promote
growth
beneficial
gut.
Nonetheless,
gaining
knowledge
interactions
between
necessary
develop
personalized
medicine
microbiota-based
therapies
for
conditions.
This
review
summarizes
studies
related
axis
particular
emphasis
Future
research
directions
are
discussed.
Language: Английский
Respiratory Microbiota and Health Risks in Children with Cerebral Palsy: A Narrative Review
Children,
Journal Year:
2025,
Volume and Issue:
12(3), P. 358 - 358
Published: March 14, 2025
Children
diagnosed
with
cerebral
palsy
(CP)
frequently
face
a
range
of
intricate
health
challenges
that
go
beyond
their
main
condition.
Respiratory
problems
represent
one
the
most
crucial
factors
contributing
to
morbidity
and
mortality.
This
review
employed
systematic
approach
identify
collate
recent
findings
on
respiratory
microbiota
in
children
CP.
The
emphasizes
notable
microbial
alterations
systems
CP,
marked
by
decrease
beneficial
bacteria
(such
as
Corynebacterium
spp.
Dolosigranulum
spp.)
an
increase
opportunistic
pathogens
like
Staphylococcus
aureus,
Pseudomonas
aeruginosa,
Klebsiella
pneumonia.
These
changes
probably
vulnerability
CP
frequent
infections,
ongoing
inflammation,
infections
are
resistant
antibiotics.
Key
influencing
composition
include
living
urban
areas,
socioeconomic
factors,
seasonal
variations,
vaccination
status,
dietary
habits,
breastfeeding,
etc.
Although
new
research
has
shed
significant
light
this
topic,
there
still
considerable
gaps
our
understanding
how
these
communities
develop
interact
immune
responses
host.
Future
should
focus
longitudinal
studies
track
over
time
interventions
optimize
Language: Английский
Intestinal-pulmonary axis: a ‘Force For Good’ against respiratory viral infections
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 18, 2025
Respiratory
viral
infections
are
a
major
global
public
health
concern,
and
current
antiviral
therapies
still
have
limitations.
In
recent
years,
research
has
revealed
significant
similarities
between
the
immune
systems
of
gut
lungs,
which
interact
through
complex
physiological
network
known
as
"gut-lung
axis."
As
one
largest
organs,
gut,
along
with
forms
an
inter-organ
network,
strong
parallels
in
innate
mechanisms,
such
activation
pattern
recognition
receptors
(PRRs).
Furthermore,
microbiota
influences
responses
lungs
mechanisms
systemic
transport
microbiota-derived
metabolites,
cell
migration,
cytokine
regulation.
Studies
shown
that
dysbiosis
can
exacerbate
severity
respiratory
may
impact
efficacy
therapies.
This
review
discusses
synergistic
role
gut-lung
axis
immunity
against
viruses
explores
potential
strategies
for
modulating
to
mitigate
infections.
Future
should
focus
on
drive
development
novel
clinical
treatment
strategies.
Language: Английский
From Microbial Ecology to Clinical Challenges: The Respiratory Microbiome’s Role in Antibiotic Resistance
Pathogens,
Journal Year:
2025,
Volume and Issue:
14(4), P. 355 - 355
Published: April 5, 2025
Antibiotic
resistance
represents
a
growing
public
health
threat,
with
airborne
drug-resistant
strains
being
especially
alarming
due
to
their
ease
of
transmission
and
association
severe
respiratory
infections.
The
microbiome
plays
pivotal
role
in
maintaining
health,
influencing
the
dynamics
antibiotic
among
pathogenic
microorganisms.
In
this
context,
review
proposes
exploration
complex
interplay
between
microbiota
antimicrobial
resistance,
highlighting
implications
diversity
disease.
Moreover,
strategies
mitigate
including
stewardship
programs,
alternatives
traditional
antibiotics,
probiotics,
restoration
techniques,
nanotechnology-based
therapeutic
interventions,
are
critically
presented,
setting
an
updated
framework
current
management
options.
Therefore,
through
better
understanding
roles
alongside
emerging
strategies,
paper
aims
shed
light
on
how
global
challenges
posed
by
multi-drug-resistant
pathogens
can
be
addressed.
Language: Английский
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota
Experimental and Molecular Pathology,
Journal Year:
2025,
Volume and Issue:
142, P. 104964 - 104964
Published: April 8, 2025
The
gut-lung
axis,
a
vital
signaling
network
linking
the
gastrointestinal
and
pulmonary
systems,
regulates
immune
responses
progression
of
respiratory
diseases.
Nutritional
components
can
modulate
gut
microbiome
regulate
synthesis
critical
intestinal
microbial
metabolites,
which
are
essential
for
maintaining
homeostasis
supporting
health.
Conversely,
poor
dietary
habits
exacerbate
asthma
other
conditions
through
modulation
systemic
inflammation
responses.
Dietary
interventions,
such
as
Mediterranean
diet,
reported
to
restore
balance
improve
health
by
increasing
production
anti-inflammatory
potentiating
responses,
preserving
epithelial
barrier
integrity.
In
contrast,
Western
patterns,
characterized
high
fat
low
fiber
intake,
disrupt
diversity,
resulting
in
increased
levels
pro-inflammatory
metabolites
that
aggravate
airway
severity.
This
review
aimed
elucidate
mechanisms
underlying
regulatory
effects
microbes
their
on
asthma.
Additionally,
previous
findings
related
axis
have
been
summarized,
providing
insights
into
potential
therapeutic
strategies
management.
Language: Английский
Influence of Microbiome Interactions on Antibiotic Resistance Development in the ICU Environment: Insights and Opportunities with Machine Learning
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
70(2), P. 14 - 14
Published: April 9, 2025
Antibiotic
resistance
is
a
global
health
crisis
exacerbated
by
the
misuse
of
antibiotics
in
healthcare,
agriculture,
and
environment.
In
an
intensive
care
unit
(ICU),
where
high
antibiotic
usage,
invasive
procedures,
immunocompromised
patients
converge,
risks
are
amplified,
leading
to
multidrug-resistant
organisms
(MDROs)
poor
patient
outcomes.
The
human
microbiome
plays
crucial
role
development
dissemination
genes
(ARGs)
through
mechanisms
like
horizontal
gene
transfer,
biofilm
formation,
quorum
sensing.
Disruptions
balance,
or
dysbiosis,
further
exacerbate
resistance,
particularly
high-risk
ICU
environments.
This
study
explores
interactions
ICU,
highlighting
machine
learning
(ML)
as
transformative
tool.
Machine
algorithms
analyze
high-dimensional
data,
predict
patterns,
identify
novel
therapeutic
targets.
By
integrating
genomic,
microbiome,
clinical
these
models
support
personalized
treatment
strategies
enhance
infection
control
measures.
results
demonstrate
potential
improve
stewardship
outcomes,
emphasizing
its
utility
ICU-specific
interventions.
conclusion,
addressing
requires
multidisciplinary
approach
combining
advanced
computational
methods,
research,
expertise.
Enhanced
surveillance,
targeted
interventions,
collaboration
essential
mitigate
care.
Language: Английский
Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
Vicky Yao,
No information about this author
Nairui Fan,
No information about this author
Shuxia Ma
No information about this author
et al.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(5)
Published: April 18, 2025
ABSTRACT
Dysbiosis
refers
to
the
disruption
of
gut
microbiota
balance
and
is
pathological
basis
various
diseases.
The
main
pathogenic
mechanisms
include
impaired
intestinal
mucosal
barrier
function,
inflammation
activation,
immune
dysregulation,
metabolic
abnormalities.
These
involve
dysfunctions
in
gut–brain
axis,
gut–liver
others
cause
broader
effects.
Although
association
between
diseases
caused
by
dysbiosis
has
been
extensively
studied,
many
questions
remain
regarding
specific
treatment
strategies.
This
review
begins
examining
causes
summarizes
potential
representative
imbalance.
It
integrates
clinical
evidence
explore
preventive
therapeutic
strategies
targeting
emphasizing
importance
understanding
dysbiosis.
Finally,
we
summarized
development
artificial
intelligence
(AI)
research
suggested
that
it
will
play
a
critical
role
future
studies
on
combining
multiomics
technologies
AI
further
uncover
complex
drive
personalized
Language: Английский
A global bibliometric map of Mendelian randomization in lung cancer research: trends, themes, and emerging risks
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 24, 2025
Although
Mendelian
randomization
(MR)
studies
on
lung
cancer
(LC)
have
grown
significantly,
a
comprehensive
bibliometric
analysis
remains
lacking.
This
study
addresses
that
gap
by
examining
global
research
trends,
leading
contributors,
and
emerging
themes
in
MR
related
to
LC.
We
conducted
of
publications
from
2005
2024,
using
data
the
Web
Science
Core
Collection.
Research
collaboration
networks,
key
were
visualized
with
VOSviewer,
CiteSpace,
R
package
'bibliometrix'.
The
included
332
2,797
researchers
across
50
countries.
A
notable
increase
occurred
after
2017,
China,
United
States,
England
as
top
contributors.
Key
institutions
University
Bristol
Nanjing
Medical
University.
most
productive
journals
Cancer
Epidemiology,
Biomarkers
&
Prevention
International
Journal
while
Nature
Genetics
was
cited.
identified
multiple
causal
pathways
for
LC
linked
inflammation,
genetics,
lifestyle
factors,
diseases,
psychiatric
conditions.
Emerging
include
roles
gut
microbiota,
schizophrenia,
C-reactive
protein,
asthma
development.
highlights
trends
areas,
particularly
inflammation
risk.
These
insights
lay
strong
foundation
advancing
personalized
prevention
treatment
future
studies.
Language: Английский
Potential of gut microbiota metabolites in treating COPD: network pharmacology and Mendelian randomization approaches
Zhenghua Cao,
No information about this author
Shengkun Zhao,
No information about this author
Tong Wu
No information about this author
et al.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Nov. 25, 2024
The
gut
microbiota
and
its
metabolites
exert
a
significant
influence
on
COPD,
yet
the
underlying
mechanisms
remain
elusive.
We
aim
to
holistically
evaluate
role
of
in
COPD
through
network
pharmacology
Mendelian
randomization
approaches.
Language: Английский