Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 25, 2024
The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate role of in COPD through network pharmacology Mendelian randomization approaches.
Language: Английский
MedComm, Journal Year: 2025, Volume and Issue: 6(5)
Published: April 18, 2025
ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized
Language: Английский
Citations
1
Life, Journal Year: 2024, Volume and Issue: 14(10), P. 1279 - 1279
Published: Oct. 9, 2024
The human gut microbiota is a complex ecosystem harboring thousands of microbial strains that play crucial role in maintaining the overall well-being its host. composition varies with age from infancy to adulthood and influenced by dietary habits, environment, genetic disposition. Recent advances culture-independent techniques nucleic acid sequencing have improved our understanding diversity microbiota. species present release short-chain fatty acids (SCFAs), which anti-inflammatory properties. also plays substantial modulating host's immune system, promoting tolerance, homeostasis. impact on health host quite evident, as dysbiosis has been linked various diseases, including metabolic disorders, autoimmune allergies, inflammatory bowel diseases. bidirectional communication respiratory creating gut-lung axis, associated different Therapeutic approaches targeting microbiota, such probiotics, prebiotics, interventions, fecal transplantation (FMT), aim restore balance promote growth beneficial gut. Nonetheless, gaining knowledge interactions between necessary develop personalized medicine microbiota-based therapies for conditions. This review summarizes studies related axis particular emphasis Future research directions are discussed.
Language: Английский
Citations
8
Children, Journal Year: 2025, Volume and Issue: 12(3), P. 358 - 358
Published: March 14, 2025
Children diagnosed with cerebral palsy (CP) frequently face a range of intricate health challenges that go beyond their main condition. Respiratory problems represent one the most crucial factors contributing to morbidity and mortality. This review employed systematic approach identify collate recent findings on respiratory microbiota in children CP. The emphasizes notable microbial alterations systems CP, marked by decrease beneficial bacteria (such as Corynebacterium spp. Dolosigranulum spp.) an increase opportunistic pathogens like Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia. These changes probably vulnerability CP frequent infections, ongoing inflammation, infections are resistant antibiotics. Key influencing composition include living urban areas, socioeconomic factors, seasonal variations, vaccination status, dietary habits, breastfeeding, etc. Although new research has shed significant light this topic, there still considerable gaps our understanding how these communities develop interact immune responses host. Future should focus longitudinal studies track over time interventions optimize
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 18, 2025
Respiratory viral infections are a major global public health concern, and current antiviral therapies still have limitations. In recent years, research has revealed significant similarities between the immune systems of gut lungs, which interact through complex physiological network known as "gut-lung axis." As one largest organs, gut, along with forms an inter-organ network, strong parallels in innate mechanisms, such activation pattern recognition receptors (PRRs). Furthermore, microbiota influences responses lungs mechanisms systemic transport microbiota-derived metabolites, cell migration, cytokine regulation. Studies shown that dysbiosis can exacerbate severity respiratory may impact efficacy therapies. This review discusses synergistic role gut-lung axis immunity against viruses explores potential strategies for modulating to mitigate infections. Future should focus on drive development novel clinical treatment strategies.
Language: Английский
Citations
0
Experimental and Molecular Pathology, Journal Year: 2025, Volume and Issue: 142, P. 104964 - 104964
Published: April 8, 2025
The gut-lung axis, a vital signaling network linking the gastrointestinal and pulmonary systems, regulates immune responses progression of respiratory diseases. Nutritional components can modulate gut microbiome regulate synthesis critical intestinal microbial metabolites, which are essential for maintaining homeostasis supporting health. Conversely, poor dietary habits exacerbate asthma other conditions through modulation systemic inflammation responses. Dietary interventions, such as Mediterranean diet, reported to restore balance improve health by increasing production anti-inflammatory potentiating responses, preserving epithelial barrier integrity. In contrast, Western patterns, characterized high fat low fiber intake, disrupt diversity, resulting in increased levels pro-inflammatory metabolites that aggravate airway severity. This review aimed elucidate mechanisms underlying regulatory effects microbes their on asthma. Additionally, previous findings related axis have been summarized, providing insights into potential therapeutic strategies management.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2025, Volume and Issue: 70(2), P. 14 - 14
Published: April 9, 2025
Antibiotic resistance is a global health crisis exacerbated by the misuse of antibiotics in healthcare, agriculture, and environment. In an intensive care unit (ICU), where high antibiotic usage, invasive procedures, immunocompromised patients converge, risks are amplified, leading to multidrug-resistant organisms (MDROs) poor patient outcomes. The human microbiome plays crucial role development dissemination genes (ARGs) through mechanisms like horizontal gene transfer, biofilm formation, quorum sensing. Disruptions balance, or dysbiosis, further exacerbate resistance, particularly high-risk ICU environments. This study explores interactions ICU, highlighting machine learning (ML) as transformative tool. Machine algorithms analyze high-dimensional data, predict patterns, identify novel therapeutic targets. By integrating genomic, microbiome, clinical these models support personalized treatment strategies enhance infection control measures. results demonstrate potential improve stewardship outcomes, emphasizing its utility ICU-specific interventions. conclusion, addressing requires multidisciplinary approach combining advanced computational methods, research, expertise. Enhanced surveillance, targeted interventions, collaboration essential mitigate care.
Language: Английский
Citations
0
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 3983 - 3995
Published: May 1, 2025
Fei-Bi decoction, a Chinese ancient experience decoction collected in the book of Bianzhenglu (Syndrome Differentiation Record). Based on Decoction, Yi-Fei-Tong-Bi (YFTBD) is developed and has significant effect treatment pulmonary fibrosis. However, underlying mechanisms YFTBD affects fibrosis remain to be elucidated. To investigate protective mechanism bleomycin-induced mice. The chemical components water extract were analyzed by combining high performance liquid chromatography (HPLC) coupled with mass spectrometry (MS). A mouse model was established intratracheal injection bleomycin, effects evaluated through pathological staining, immunohistochemistry analyses, Enzyme-Linked Immunosorbent Assay (ELISA). Subsequently, gut microbiota mice 16S rRNA high-throughput gene sequencing. Compared group, survival rate lung coefficient increased after intervention YFTBD, morphology tissue improved, expression inflammatory factor levels decreased. α-SMA, TGF-β1, p21, p16 senescence-related proteins significantly down-regulated. Smad7 PGC-1α up-regulated. Meanwhile, analysis showed that could induce changes abundance Alloprevotella, unclassified Muribaculaceae, Lachnospiraceae NK4A136 group. Our findings suggest alleviate via regulating TGF-β1/Smad signaling pathway, inflammation microbiota. It provides experimental evidence theoretical basis for application
Language: Английский
Citations
0
Pathogens, Journal Year: 2025, Volume and Issue: 14(4), P. 355 - 355
Published: April 5, 2025
Antibiotic resistance represents a growing public health threat, with airborne drug-resistant strains being especially alarming due to their ease of transmission and association severe respiratory infections. The microbiome plays pivotal role in maintaining health, influencing the dynamics antibiotic among pathogenic microorganisms. In this context, review proposes exploration complex interplay between microbiota antimicrobial resistance, highlighting implications diversity disease. Moreover, strategies mitigate including stewardship programs, alternatives traditional antibiotics, probiotics, restoration techniques, nanotechnology-based therapeutic interventions, are critically presented, setting an updated framework current management options. Therefore, through better understanding roles alongside emerging strategies, paper aims shed light on how global challenges posed by multi-drug-resistant pathogens can be addressed.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 24, 2025
Although Mendelian randomization (MR) studies on lung cancer (LC) have grown significantly, a comprehensive bibliometric analysis remains lacking. This study addresses that gap by examining global research trends, leading contributors, and emerging themes in MR related to LC. We conducted of publications from 2005 2024, using data the Web Science Core Collection. Research collaboration networks, key were visualized with VOSviewer, CiteSpace, R package 'bibliometrix'. The included 332 2,797 researchers across 50 countries. A notable increase occurred after 2017, China, United States, England as top contributors. Key institutions University Bristol Nanjing Medical University. most productive journals Cancer Epidemiology, Biomarkers & Prevention International Journal while Nature Genetics was cited. identified multiple causal pathways for LC linked inflammation, genetics, lifestyle factors, diseases, psychiatric conditions. Emerging include roles gut microbiota, schizophrenia, C-reactive protein, asthma development. highlights trends areas, particularly inflammation risk. These insights lay strong foundation advancing personalized prevention treatment future studies.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 25, 2024
The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate role of in COPD through network pharmacology Mendelian randomization approaches.
Language: Английский
Citations
0