Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia DOI Open Access

Alejandro García-Navarro,

María Isabel Vasallo-Morillas,

Roge Navarro-Belmonte

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2900 - 2900

Published: Aug. 30, 2024

This study aimed to assess the impact of a combination probiotic strains Lactiplantibacillus on treatment androgenic alopecia (AGA). To this end, 136 individuals with AGA (62 men and 74 women) aged 18–65 years were enrolled in double-blind, parallel-group clinical trial. A total 115 (57 group 58 placebo group) completed within 16-week intervention period. Capillary density, thickness, length hair analyzed before after using FotoFinder Trichoscale Pro. In addition, gut microbiota was assessed by paired-end sequencing Illumina MiSeq platform (2 × 300 bp). At conclusion period, notable decline (p < 0.05) number telogen hairs evident while thickness decreased 0.05). However, remaining variables did not exhibit any statistically significant changes. probiotic-treated group, less than 37.5 exhibited reduction density = 0.0693 p 0.0669, respectively) an increase 0.0871). Furthermore, vellus observed, accompanied no change thickness. The significantly higher abundance Lactobacillus (p-adjusted 0.05, DEseq2 test) demonstrated hair, percentage anagen hair. mixture well tolerated participants, adherence rate 90%. light study’s limitations, it can be concluded that three promotes presence terminal follicles, preventing their gradual miniaturization, which is characteristic AGA.

Language: Английский

Genetic Variants and Lifestyle Factors in Androgenetic Alopecia Patients: A Case–Control Study of Single Nucleotide Polymorphisms and Their Contribution to Baldness Risk DOI Open Access
Roberto Ambra, Simona Mastroeni, Sonia Manca

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 299 - 299

Published: Jan. 15, 2025

Single nucleotide polymorphisms (SNPs) found to be associated with Androgenetic Alopecia (AGA) date, are characterized by an apparent reduced penetrance into the phenotype suggesting a role of other factors in etiology AGA. Objective: We conducted study investigate specific allelic variants AGA controlling for nutritional and lifestyle factors. Methods: Individual patterns SNPs present baldness susceptibility locus at 20p11 (rs1160312 rs6113491) or close androgen receptor (AR) gene chromosome X (rs1041668) were investigated 212 male subjects. Information on socio-demographic characteristics, medical history, smoking, diet was also collected. Logistic regression used estimate odds ratios (ORs) 95% confidence intervals (CIs). Results: After age, diet, BMI, family history AGA, increased risk subjects [A] alleles both rs1160312 (OR: 2.97; CI: 1.34–6.62) rs6113491 2.99; 1.37–6.52), TT genotype rs1041668 4.47; 1.60–12.5). Multivariate logistic indicates that familiarity, but not remain statistically significant despite different SNP genotypes. Conclusions: To our knowledge, this is first indication rs1160312, rs6113491, independent can modulated diet.

Language: Английский

Citations

0
Unhealthy diet and lifestyle factors linked to female androgenetic alopecia: a community-based study from Jidong study, China DOI Creative Commons

Lin Peng,

Yuhe Liu, Wenqian Wu

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 13, 2025

To explore unhealthy diet and lifestyle factors associated with female androgenetic alopecia (FAGA) in a community-based study. A total of 3,008 participants were recruited from the Jidong community (Tangshan, Hebei, China). FAGA was assessed by Savin scale. Data collection conducted through structured questionnaires. Univariate multivariate logistic regression analyses employed to identify potential factors. Multivariable models built selecting covariates P < 0.05 univariable removing collinear variables identified variance inflation factor > 5. The predictive performance evaluated using receiver operating characteristic curve. prevalence this study 6.85% (206/3008). Sleep snoring (adjusted odds ratio [AOR] = 1.398, 95% confidence interval [CI] 1.032–1.894, 0.031), frequent consumption bacon preserved meat (AOR 2.205, CI 1.181–4.118, 0.013), frequently drinking unboiled water 1.984, 1.156–3.406, age 1.063, 1.050–1.076, 0.001) suboptimal health status score 1.033, 1.020–1.047, as independent FAGA. In conclusion, our data suggest that females who snore during sleep, consume meats, regularly drink are more susceptible alopecia. Additionally, analysis revealed significantly correlated

Language: Английский

Citations

0
Key players inducing skin diseases and skin aging and potential preventive or therapeutic strategies using phytochemicals DOI Creative Commons
Hamid M. Abdolmaleky, Jin‐Rong Zhou

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100073 - 100073

Published: Feb. 1, 2025

Language: Английский

Citations

0
Immune and Non-immune Interactions in the Pathogenesis of Androgenetic Alopecia DOI
Yu Xiao, Yi Zhang,

Shuting Deng

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 1, 2025

Language: Английский

Citations

0
Randomized Clinical Trial to Evaluate the Effect of Probiotic Intake on Androgenic Alopecia DOI Open Access

Alejandro García-Navarro,

María Isabel Vasallo-Morillas,

Roge Navarro-Belmonte

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2900 - 2900

Published: Aug. 30, 2024

This study aimed to assess the impact of a combination probiotic strains Lactiplantibacillus on treatment androgenic alopecia (AGA). To this end, 136 individuals with AGA (62 men and 74 women) aged 18–65 years were enrolled in double-blind, parallel-group clinical trial. A total 115 (57 group 58 placebo group) completed within 16-week intervention period. Capillary density, thickness, length hair analyzed before after using FotoFinder Trichoscale Pro. In addition, gut microbiota was assessed by paired-end sequencing Illumina MiSeq platform (2 × 300 bp). At conclusion period, notable decline (p < 0.05) number telogen hairs evident while thickness decreased 0.05). However, remaining variables did not exhibit any statistically significant changes. probiotic-treated group, less than 37.5 exhibited reduction density = 0.0693 p 0.0669, respectively) an increase 0.0871). Furthermore, vellus observed, accompanied no change thickness. The significantly higher abundance Lactobacillus (p-adjusted 0.05, DEseq2 test) demonstrated hair, percentage anagen hair. mixture well tolerated participants, adherence rate 90%. light study’s limitations, it can be concluded that three promotes presence terminal follicles, preventing their gradual miniaturization, which is characteristic AGA.

Language: Английский

Citations

0