Causal Links Between Brain Functional Networks and Endometriosis: A Large-Scale Genetic-Driven Observational Study

International Journal of Women s Health, Journal Year: 2025, Volume and Issue: Volume 17, P. 369 - 376

Published: Feb. 1, 2025

Introduction: Endometriosis is a chronic gynecological disorder that significantly impacts women of reproductive age. Recent evidence suggests bidirectional link between endometriosis and brain functional networks, though the causal mechanisms remain unclear. This study aims to explore these relationships using Mendelian Randomization (MR) analysis. Methods: Data from 191 resting-state MRI (rsfMRI) phenotypes genetic datasets were analyzed both forward reverse MR approaches. Genetic Instrument Selection was performed identify valid instrumental variables, ensuring their independence confounders strong association with exposure. Sensitivity analyses conducted ensure robustness findings. Results: Forward analysis identified three networks (Pheno20, Pheno38, Pheno44) associated risk (P FDR < 0.05). Notably, Pheno38 activity inversely fallopian tube endometriosis, whereas Pheno20 Pheno44 positively linked adenomyosis. Reverse revealed ovary connectivity in Pheno932, network involved cognitive attention processes. confirmed reliability results. Discussion: highlights complex relationship endometriosis. Increased specific may protect against or predispose individuals certain subtypes Conversely, also can influence connectivity, potentially contributing emotional symptoms. Keywords: fMRI, randomization

Language: Английский

Broadening horizons: microbiota as a novel biomarker and potential treatment for endometriosis

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

As a heterogeneous disease, endometriosis is associated with diagnostic delay. Delayed diagnosis, physical discomfort, hormone therapy, and inconvenience in daily life work all contribute to decreased quality of for patients. Early clinical diagnosis highly important the intervention treatment endometriosis. Currently, reliable non-invasive methods are lacking, laparoscopic examination combined pathological considered "gold standard" definitively diagnosing An increasing number studies have confirmed correlation between microbial ecological changes. Microbial dysbiosis an factor development progression Certain key species their metabolites can induce functional alterations endometrial cells through various mechanisms, often preceding emergence symptoms. Endometriosis chronic inflammatory diseases, immunoinflammatory response as foundation. The microbiome may participate mechanisms multiple pathways, including mediating responses, regulating immune participating estrogen regulation, interfering metabolic activities, modulating gut-brain axis. Therefore, holds potential early therapeutic target This study summarizes analyses correlations microorganisms onset endometriosis, aiming provide novel insights into etiology,

Language: Английский

The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study

Gynecological Endocrinology, Journal Year: 2024, Volume and Issue: 40(1)

Published: Dec. 23, 2024

Background Previous studies on the impact of mitochondrial DNA (mtDNA) copy number female infertility were limited and inconsistent.

Language: Английский