Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort DOI Open Access

Ayushi Trivedi,

Dipro Bose,

Kelly Moffat

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(8), P. 1102 - 1102

Published: Aug. 21, 2024

Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990–1991 War. Fatigue, GI complaints, other symptoms continue persist more than 30 years post-deployment. Several potential mechanisms for persistent illness have been identified our prior pilot study linked an altered gut microbiome with disorder. This further validates builds on preliminary findings of host dysbiosis GWI. Using stool samples Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases 26 controls) Boston biorepository, recruitment, integrative network (BBRAIN) Illness, we found that bacterial signature showed significantly different Bray–Curtis beta diversity control veterans. Specifically, higher Firmicutes Bacteroidetes ratio, decrease Akkermansia sp., Bacteroides thetaiotamicron, fragilis, Lachnospiraceae genera increase Blautia, Streptococcus, Klebsiella, Clostridium genera, are associated gut, immune, brain health, shown. Further, using MaAsLin Boruta algorithms, Coprococcus Eisenbergiella as important predictors area under curve ROC predictive value 74.8%. Higher self-reported MFI scores also species abundance Blautia. These results suggest therapeutic targets target specific illness.

Language: Английский

Integrating the milk microbiome signatures in mastitis: milk-omics and functional implications DOI Creative Commons
Rine Christopher Reuben, Cármen Torres

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 18, 2025

Mammalian milk contains a variety of complex bioactive and nutritional components microorganisms. These microorganisms have diverse compositions functional roles that impact host health disease pathophysiology, especially mastitis. The advent use high throughput omics technologies, including metagenomics, metatranscriptomics, metaproteomics, metametabolomics, as well culturomics in microbiome studies suggest strong relationships between phenotype signatures While single undoubtedly contributed to our current understanding mastitis, they often provide limited information, targeting only biological viewpoint which is insufficient system-wide information necessary for elucidating the footprints molecular mechanisms driving mastitis dysbiosis. Therefore, integrating multi-omics approach research could generate new knowledge, improve structural ecosystem, insights sustainable control management.

Language: Английский

Citations

1
Skin Microbiome Dynamics in Atopic Dermatitis: Understanding Host-Microbiome Interactions DOI Open Access
Han Bi Kim, Helen Alexander, Ji‐Young Um

et al.

Allergy Asthma and Immunology Research, Journal Year: 2025, Volume and Issue: 17(2), P. 165 - 165

Published: Jan. 1, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder affecting both children and adults, characterized by pruritus, eczematous lesions, compromised barrier function. A key feature of AD dysbiosis the microbiome, marked reduced microbial diversity overgrowth Staphylococcus aureus in lesional skin. S. exacerbates dysfunction immune dysregulation, leading to recurrent infections disease flares. In contrast, commensal bacteria such as epidermidis Roseomonas mucosa may exert protective effects inhibiting colonization modulating responses. Beyond composition, metabolites play crucial role pathophysiology. Short-chain fatty acids, indole derivatives, other bacterial influence cutaneous responses, lipid metabolism, integrity. Altered metabolite profiles, including levels beneficial metabolites, are associated with severity progression. Notably, overabundance correlates disruption further compromising barrier. This review explores recent advances understanding relationship between pathogenesis examines therapeutic potential microbiome-targeted interventions. Strategies probiotics, prebiotics, topical microbiome transplantation aim restore rebalance production, ultimately improving clinical outcomes patients. Future approaches focusing on commensal-derived offer promising avenues for alleviating symptoms AD.

Language: Английский

Citations

0
Cytokine profile of the stratum corneum in atopic dermatitis lesions differs between the face and the trunk DOI Creative Commons
Makiko Kido‐Nakahara,

Takahito Chiba,

Yuta Mizusawa

et al.

Allergology International, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2
Omics Insights in Responses of Bivalves Exposed to Plastic Pollution DOI

Robert Mkuye,

Chuangye Yang, Fortunatus Masanja

et al.

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 279, P. 107224 - 107224

Published: Dec. 28, 2024

Language: Английский

Citations

0
Gulf War Illness Is Associated with Host Gut Microbiome Dysbiosis and Is Linked to Altered Species Abundance in Veterans from the BBRAIN Cohort DOI Open Access

Ayushi Trivedi,

Dipro Bose,

Kelly Moffat

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(8), P. 1102 - 1102

Published: Aug. 21, 2024

Gulf War Illness (GWI) is a debilitating condition marked by chronic fatigue, cognitive problems, pain, and gastrointestinal (GI) complaints in veterans who were deployed to the 1990–1991 War. Fatigue, GI complaints, other symptoms continue persist more than 30 years post-deployment. Several potential mechanisms for persistent illness have been identified our prior pilot study linked an altered gut microbiome with disorder. This further validates builds on preliminary findings of host dysbiosis GWI. Using stool samples Multidimensional Fatigue Inventory (MFI) data from 89 GW veteran participants (63 GWI cases 26 controls) Boston biorepository, recruitment, integrative network (BBRAIN) Illness, we found that bacterial signature showed significantly different Bray–Curtis beta diversity control veterans. Specifically, higher Firmicutes Bacteroidetes ratio, decrease Akkermansia sp., Bacteroides thetaiotamicron, fragilis, Lachnospiraceae genera increase Blautia, Streptococcus, Klebsiella, Clostridium genera, are associated gut, immune, brain health, shown. Further, using MaAsLin Boruta algorithms, Coprococcus Eisenbergiella as important predictors area under curve ROC predictive value 74.8%. Higher self-reported MFI scores also species abundance Blautia. These results suggest therapeutic targets target specific illness.

Language: Английский

Citations

0