Necrotizing Laryngitis in Patients with Hematologic Disease: The First Case-Report Due to PDR Acinetobacter baumannii and Literature Review DOI Creative Commons

Ioanna Tatouli,

N Dedes, Andreas Bozikas

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1382 - 1382

Published: July 8, 2024

Immunocompromised patients with hematologic diseases may experience life-threatening infections rather uncommon manifestations. Laryngitis has been described as a potential infection in such vulnerable and result major complications, ranging from impending airway obstruction to total laryngeal necrosis. Immediate laryngoscopy is of paramount importance, it provides quantification edema evidence Documentation the causative pathogen usually feasible through tissue culture. In literature, 14 cases necrotizing laryngitis have already published. Here, we present case 38-year-old male recent diagnosis multiple myeloma, who received first cycle therapy few days before admission. The patient presented neutropenic fever, diarrhea, organ dysfunction. His course was complicated hemophagocytic lymphohistiocytosis stridor. A attributed Acinetobacter baumannii invasion larynx established. This manuscript highlights that management disease should be coordinated highly specialized centers clinicians high level clinical suspicion act promptly.

Language: Английский

Sulbactam–Durlobactam for Carbapenem-Resistant Acinetobacter baumannii–calcoaceticus Complex Infections DOI

Nino Marzella,

Troy Kish,

Carmen-Sarah Costinaș

et al.

American Journal of Therapeutics, Journal Year: 2025, Volume and Issue: 32(2), P. e151 - e158

Published: Feb. 27, 2025

Background: Antimicrobial resistance (AMR) is a major health crisis specifically associated with Acinetobacter. Among different Acinetobacter species, baumannii known as the greatest culprit concerning clinical significance. Of most importance, carbapenem-resistant A. baumannii–calcoaceticus complex (CRAB) infections are fourth leading global cause of death attributable to AMR. Consequently, CRAB has been established globally top priority pathogen for development novel antimicrobials. Sulbactam-–durlobactam received Food and Drug Administration (FDA) approval target this resistant microorganism. Mechanism Action, Pharmacodynamics, Pharmacokinetics: This innovative combination uses sulbactam, which first-generation β-lactamase inhibitor antibacterial activity against spp. Considering sulbactam susceptible cleavage by numerous β-lactamases, benefit coformulated product addition durlobactam. Durlobactam new member diazabicyclooctane class inhibitors broad spectrum several serine making it able restore sulbactam's exclusively multidrug-resistant strains. Overall, pharmacokinetic pharmacodynamic parameter time above minimum inhibitory concentration (T >MIC) durlobactam 24-hour unbound area under curve. The estimated half-life sulbactam–durlobactam approximately 2 hours. Clinical Trials: ATTACK, phase 3 trial, used in patients laboratory-confirmed CRAB. primary efficacy end point was 28-day all-cause mortality. noninferior colistin. drug well tolerated effective reducing mortality from serious caused CRAB, along group had significantly lower incidence nephrotoxicity. Therapeutic Advance: Sulbactam–durlobactam an unconventional dual product. It holds other agents, yet fewer kidney side effects. deserves be regarded important agent added current battlefield landscape multiple organisms encountered medical practice.

Language: Английский

Citations

0
A Review of In Silico and In Vitro Approaches in the Fight Against Carbapenem‐Resistant Enterobacterales DOI Creative Commons

Muhammad Absar,

Abdul Rahman Zaidah, Amer Mahmood

et al.

Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

ABSTRACT Objectives The rise in carbapenem‐resistant Enterobacterales (CRE) has reinforced the global quest for developing effective therapeutics. Traditional drug discovery approaches have been inadequate overcoming this challenge due to their resource and time constraints. Methods English literature was searched by structured queries related our review between January 1, 2020, December 31, 2024. Results key resistance mechanisms CRE, such as enzymatic hydrolysis, decreased permeability, efflux pump overexpression, examined review. Computational technologies become pivotal discovering novel antimicrobial agents with improved accuracy efficiency. Besides this, highlights advances structure‐ ligand‐based identifying potential drugs against CRE. Recent studies demonstrating use of silico techniques develop targeted CRE also explored. Moreover, underscores significance integrating both vitro counter Enterobacterales, supported latest studies. However, these promising computational a few major drawbacks, lack standardized parameterization, potentially false positives, complexity clinical translations. regulatory barriers restrict progress new antimicrobials market approval. Conclusion inhibitor is gaining popularity, it can be expedited refining them reliable validation. innovative hybrid need hour tackle mitigate threat resistance.

Language: Английский

Citations

0
Biosensing for rapid detection of MDR, XDR and PDR bacteria DOI

Samad Rastmanesh,

Ilghar Zeinaly,

Vahid Alivirdiloo

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120121 - 120121

Published: Dec. 1, 2024

Language: Английский

Citations

3
Necrotizing Laryngitis in Patients with Hematologic Disease: The First Case-Report Due to PDR Acinetobacter baumannii and Literature Review DOI Creative Commons

Ioanna Tatouli,

N Dedes, Andreas Bozikas

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1382 - 1382

Published: July 8, 2024

Immunocompromised patients with hematologic diseases may experience life-threatening infections rather uncommon manifestations. Laryngitis has been described as a potential infection in such vulnerable and result major complications, ranging from impending airway obstruction to total laryngeal necrosis. Immediate laryngoscopy is of paramount importance, it provides quantification edema evidence Documentation the causative pathogen usually feasible through tissue culture. In literature, 14 cases necrotizing laryngitis have already published. Here, we present case 38-year-old male recent diagnosis multiple myeloma, who received first cycle therapy few days before admission. The patient presented neutropenic fever, diarrhea, organ dysfunction. His course was complicated hemophagocytic lymphohistiocytosis stridor. A attributed Acinetobacter baumannii invasion larynx established. This manuscript highlights that management disease should be coordinated highly specialized centers clinicians high level clinical suspicion act promptly.

Language: Английский

Citations

0