Red snapper protein prevents chronic unpredictable mild stress-induced ileal barrier damage by reversing microbiota-derived butyric acid overload

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106233 - 106233

Published: Feb. 1, 2025

Language: Английский

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Targeting gut-immune-heart modulate cardiac remodeling after acute myocardial infarction

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123606 - 123606

Published: April 1, 2025

The gut microbiota interacts with the host to regulate disease and health status. An increasing number of studies have recognized bidirectional regulation between immune cells, which plays a significant role in etiology prognosis diseases. Gut is also crucial regulatory factor cardiovascular After acute myocardial infarction, endothelial damage rapidly triggers an inflammatory response, activating system disrupting ecology, thereby affecting cardiac remodeling after infarction potentially leading heart failure. We elucidated mechanisms complex intercellular networks during infarction. Furthermore, this research examines roles microbiota, metabolites relation failure Finally, we discuss potential targeting cells as effective approach prevent treat future, through methods such dietary regulation, probiotic supplementation, transplantation.

Language: Английский

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Advances in Metabolomics: A Comprehensive Review of Type 2 Diabetes and Cardiovascular Disease Interactions

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3572 - 3572

Published: April 10, 2025

Type 2 diabetes (T2D) and cardiovascular diseases (CVDs) are major public health challenges worldwide. Metabolomics, the exhaustive assessment of metabolites in biological systems, offers important insights regarding metabolic disturbances related to these disorders. Recent advances toward integration metabolomics into clinical practice facilitate discovery novel biomarkers that can improve diagnosis, prognosis, treatment T2D CVDs discussed this review. Metabolomics potential characterize key alterations associated with disease pathophysiology treatment. is a heterogeneous develops through diverse pathophysiological processes molecular mechanisms; therefore, disease-causing pathways not completely understood. studies have identified several robust clusters variants representing biologically meaningful, distinct pathways, such as beta cell proinsulin cluster pancreatic insulin secretion, obesity, lipodystrophy, liver/lipid cluster, glycemia, blood pressure, syndrome different causing resistance. Regarding CVDs, recent allowed metabolomic profile delineate contribute atherosclerosis heart failure, well development targeted therapy. This review also covers role integrated genomics other omics platforms better understand mechanisms, along transition precision medicine. further investigates use multi-metabolite modeling enhance risk prediction models for predicting first occurrence adverse events among individuals T2D, highlighting value approaches optimizing preventive therapeutic used practice.

Language: Английский

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Gut-Microbiota-Derived Butyric Acid Overload Contributes to Ileal Mucosal Barrier Damage in Late Phase of Chronic Unpredictable Mild Stress Mice

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12998 - 12998

Published: Dec. 3, 2024

Intestinal mucosal barrier damage is regarded as the critical factor through which chronic unpredictable mild stress (CUMS) leads to a variety of physical and mental health problems. However, exact mechanism by CUMS induces intestinal unclear. In this study, 14, 28, 42 d model mice were established. The indicators related ileal (IMBD), composition microbiota its amino acid (AA) short-chain fatty (SCFA) metabolic functions, free (FAA) SCFA levels in lumen measured before after each period. correlations between them are analyzed investigate how male C57BL/6 mice. With progression CUMS, butyric (BA) decreased (14 28 d) then increased (42 d), IMBD progressively increased. late stage degree most severe positively correlated with significantly BA (

Language: Английский

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A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 21, 2024

Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, inflammation, have been identified with boosting morbidity mortality due to the dearth of efficacious therapeutic interventions. In recent years, studies shown that variations in gut microbiota its own metabolites can influence occurrence CMDs. Intriguingly, composition function are susceptible exercise patterns, thus affecting inflammatory, immune, responses within host. this review, we introduce key mechanisms intestinal microecology involved onset development CMDs, discuss relationship between microecology, then analyze role beneficial effects on aiming at elucidating gut-heart axis mediated protective effect building avenues for application management

Language: Английский

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