Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140221 - 140221

Published: Jan. 22, 2025

Language: Английский

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Does Clostridium Perfringens Epsilon Toxin Mimic an Auto-Antigen Involved in Multiple Sclerosis?

Toxins, Journal Year: 2025, Volume and Issue: 17(1), P. 27 - 27

Published: Jan. 7, 2025

Multiple sclerosis (MS) is a chronic immune-mediated neurological disorder, characterized by progressive demyelination and neuronal cell loss in the central nervous system. Many possible causes of MS have been proposed, including genetic factors, environmental triggers, infectious agents. Recently, Clostridium perfringens epsilon toxin (ETX) has incriminated MS, based initially on isolation bacteria from patient, combined with an immunoreactivity to ETX. To investigate putative causative role ETX we analyzed pattern antibodies reacting using sensitive qualitative assay. This prospective observational study included one hundred patients relapsing remitting multiple (RRMS), all untreated, ninety matched healthy controls. By assessing isotypic serum concentration ETX-reacting antibodies, our shows predominant IgM response over IgG IgA antibody responses both controls, significantly higher levels compared control group. A longitudinal follow-up ETX-specific subgroup did not show any correlation disease evolution. Overall, these unexpected findings are compatible specific recognition patients. They rather argue for cross immunological reactivity antigen, possibly autoantigen, mimicking Thus, data against hypothesis causal relationship between C. MS.

Language: Английский

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Hydroxytyrosol as a Mitochondrial Homeostasis Regulator: Implications in Metabolic Syndrome and Related Diseases

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 398 - 398

Published: March 27, 2025

Hydroxytyrosol (HT), a principal bioactive phytochemical abundant in Mediterranean dietary sources, has emerged as molecule of significant scientific interest owing to its multifaceted health-promoting properties. Accumulating evidence suggests that HT’s therapeutic potential metabolic disorders extends beyond conventional antioxidant capacity encompass mitochondrial regulatory networks. This review synthesizes contemporary from our systematic investigations and the existing literature delineate comprehensive modulatory effects on homeostasis. We systematically summarized impact HT dynamics (fusion/fission equilibrium), biogenesis energy metabolism, mitophagy, inter-organellar communication with endoplasmic reticulum, microbiota–mitochondria crosstalk. Through this multidimensional analysis, we established homeostasis modulator applications syndrome (MetS) related pathologies including type 2 diabetes mellitus, obesity-related dysfunction, dyslipidemia, non-alcoholic steatohepatitis, hypertension-related complications. Moreover, further discussed translational challenges research, emphasizing imperative for direct target identification, mitochondrial-targeted delivery system development, combinatorial strategies. Collectively, provides mechanistic framework advancing research accelerating clinical implementation MetS diseases.

Language: Английский

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The mitochondria-gut microbiota crosstalk – a novel frontier in cardiovascular diseases

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: 998, P. 177562 - 177562

Published: March 29, 2025

Language: Английский

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