Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review

Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 200 - 200

Published: Feb. 10, 2025

Polyphenols (PPs) are recognized as bioactive compounds and antimicrobial agents, playing a critical role in enhancing food safety, preservation, extending shelf life. The effectiveness of PPs has different molecular biological reasons, predominantly linked to their hydroxyl groups electron delocalization, which interact with microbial cell membranes, proteins, organelles. These interactions may reduce the efficiency metabolic pathways, cause destructive damage membrane, or they harm proteins nucleic acids foodborne bacteria. Moreover, exhibit distinctive ability form complexes metal ions, further amplifying activity. This narrative review explores complex multifaceted between pathogens, underlying correlation chemical structures mechanisms action. Such insights shed light on potential innovative natural preservatives within systems, presenting an eco-friendly sustainable alternative synthetic additives.

Language: Английский

In vitro and in vivo antimicrobial activity of medicated wipes containing biosecur on the microbial Flora of the eyelid and conjunctiva

European Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Purpose To evaluate the in vitro and vivo antimicrobial activity on microbial flora of eyelids conjunctiva new medicated wipes LENIVA bio, soaked with an antiseptic solution containing natural extracts from citrus fruits (Biosecur ® ), Aloe vera , Ruscus aculeatus . Methods The bio against bacteria fungi commonly found periocular area, including antibiotic-resistant strains, was measured by agar diffusion microdilution assays. swabs collected eyelid rim 20 patients (13 males, 7 females; mean age 70.5 years) before after a 4-day treatment product. Contralateral untreated eyes were used as controls. Results analysis inhibition halos assays demonstrated that is active all tested germs, even when diluted. In reduction total counts obtained both conjunctival following statistically significant (respectively, = 4530 CFU/ml, p < 0.0001; 893 0.0384). Conclusion showed microorganisms are potential pathogens eye and/or area.

Language: Английский

Retention of methicillin susceptibility in Staphylococcus aureus using natural adjuvant as an allosteric modifier of penicillin-binding protein 2a

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 181, P. 109070 - 109070

Published: Aug. 27, 2024

Language: Английский