Characterization of Sex-Based Differences in Gut Microbiota That Correlate with Suppression of Lupus in Female BWF1 Mice DOI Creative Commons
James W Harder, Jing Ma, James Collins

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1023 - 1023

Published: April 29, 2025

Systemic lupus erythematosus (SLE) is more prevalent in female mice and humans associated with microbiota dysbiosis. We analyzed the fecal composition male NZBxNZWF1 (BWF1) mice, a model of SLE, using 16S RNA gene sequencing. Composition gut differed between adult disease-prone (pre-disease) disease-resistant mice. Transfer cecal contents by gavage into suppressed kidney disease (decreased proteinuria) improved survival. After our mouse colony was moved to new barrier facility similar housing, transplants failed suppress recipients. two years, protective phenotype reemerged: once again compared BWF1 for three different periods, during which either protected or protect In vs. receiving transplants, we found Bacteroides high, Clostridium low (high Bacteroides/Clostridium ratio), Alistipes present periods when disease. These data suggest that specific bacterial populations may have opposing effects on suppression transplantation.

Language: Английский

Characterization of Sex-Based Differences in Gut Microbiota That Correlate with Suppression of Lupus in Female BWF1 Mice DOI Creative Commons
James W Harder, Jing Ma, James Collins

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1023 - 1023

Published: April 29, 2025

Systemic lupus erythematosus (SLE) is more prevalent in female mice and humans associated with microbiota dysbiosis. We analyzed the fecal composition male NZBxNZWF1 (BWF1) mice, a model of SLE, using 16S RNA gene sequencing. Composition gut differed between adult disease-prone (pre-disease) disease-resistant mice. Transfer cecal contents by gavage into suppressed kidney disease (decreased proteinuria) improved survival. After our mouse colony was moved to new barrier facility similar housing, transplants failed suppress recipients. two years, protective phenotype reemerged: once again compared BWF1 for three different periods, during which either protected or protect In vs. receiving transplants, we found Bacteroides high, Clostridium low (high Bacteroides/Clostridium ratio), Alistipes present periods when disease. These data suggest that specific bacterial populations may have opposing effects on suppression transplantation.

Language: Английский

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