Alcohol accelerates the development of esophageal squamous cell carcinoma through elevated Gram-negative bacteria in peripheral circulation DOI Creative Commons
Zehua Zhang, Le Kang, Yongchun Gu

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 25, 2025

Abstract Alcohol consumption is intricately linked to the incidence of esophageal squamous cell carcinoma (ESCC). This study comprehensively investigates role alcohol-induced microbial alterations in ESCC progression. A retrospective analysis 328 patients demonstrated that alcohol markedly increases risk and boosts expression proliferation marker Ki67. Patients with alcohol-related exhibited substantially higher blood microbiome diversity, characterized by dominance Gram-negative bacteria, elevated serum lipopolysaccharides (LPS) levels. In a mouse model, not only augmented tumor burden but also compromised gut barrier integrity, facilitating bacterial translocation. Significant elevations such as Bacteroidales Escherichia coli tissues, were observed. Mechanistically, LPS synergistically activated pro-inflammatory pathways, including TNF, TLR, NF-κB, MAPK, which fueled proliferation. Meanwhile, triggered necroptosis normal epithelial cells. These findings reveal dysbiosis peripheral circulation LPS-mediated inflammatory responses form novel pathogenic mechanism ESCC. Targeting bacteria could provide promising therapeutic strategy for managing Further research urgently warranted explore interaction between changes microenvironment.

Language: Английский

Alcohol accelerates the development of esophageal squamous cell carcinoma through elevated Gram-negative bacteria in peripheral circulation DOI Creative Commons
Zehua Zhang, Le Kang, Yongchun Gu

et al.

Experimental Hematology and Oncology, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 25, 2025

Abstract Alcohol consumption is intricately linked to the incidence of esophageal squamous cell carcinoma (ESCC). This study comprehensively investigates role alcohol-induced microbial alterations in ESCC progression. A retrospective analysis 328 patients demonstrated that alcohol markedly increases risk and boosts expression proliferation marker Ki67. Patients with alcohol-related exhibited substantially higher blood microbiome diversity, characterized by dominance Gram-negative bacteria, elevated serum lipopolysaccharides (LPS) levels. In a mouse model, not only augmented tumor burden but also compromised gut barrier integrity, facilitating bacterial translocation. Significant elevations such as Bacteroidales Escherichia coli tissues, were observed. Mechanistically, LPS synergistically activated pro-inflammatory pathways, including TNF, TLR, NF-κB, MAPK, which fueled proliferation. Meanwhile, triggered necroptosis normal epithelial cells. These findings reveal dysbiosis peripheral circulation LPS-mediated inflammatory responses form novel pathogenic mechanism ESCC. Targeting bacteria could provide promising therapeutic strategy for managing Further research urgently warranted explore interaction between changes microenvironment.

Language: Английский

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