Selenium Broussonetia papyrifera polysaccharide alleviated cyclophosphamide-induced immune suppression, growth inhibition, intestinal damage, and gut microbiota disorder in yellow-feather broilers.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(4), P. 104907 - 104907

Published: Feb. 17, 2025

This study aims to investigate the effects of selenium Broussonetia papyrifera polysaccharide (Se-BPP) on growth performance, immune regulation, intestinal barrier function, and gut microbiota in cyclophosphamide (CTX)-induced immunosuppressed chicks. A total 120 one-day-old male yellow-feathered broilers were randomly divided into five groups: normal control group (NC), model (MC), low-dose Se-BPP (Se-L), high-dose (Se-H), Astragalus (APS) The Se-L Se-H groups supplemented with 0.1 % or 0.2 Se-BPP, respectively, while APS was APS. On days 22, 24, 26, NC received intramuscular injections 80 mg/kg saline, other same dose CTX induce immunosuppression results showed that caused retardation, immunosuppression, damage, alterations structure. Supplementation improved average daily gain reduced feed-to-gain ratio, promoting increased organ index serum content IgG, IgM, IgA, SOD, GSH-Px, CAT, IL-2, IL-4, IL-6, IL-10, INF-γ, thus alleviating oxidative stress by CTX. Additionally, enhanced mRNA expression levels ZO-1, Claudin 1, MUC2 villus height jejunum, effectively mitigating damage induced Although effect alpha diversity not significant, it abundance beneficial bacteria such as Ruminococcus Lactobacillus. In brief, this demonstrated adding diet could improve disturbances yellow-feather broiler chickens challenged CTX, enhancing their production performance.

Language: Английский

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Exploring the top 30 drugs associated with drug-induced constipation based on the FDA adverse event reporting system

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 2, 2024

Objective This project aims to identify the top 30 drugs most commonly associated with constipation and their signal values within FDA Adverse Event Reporting System database. Methods We extracted adverse drug events (ADEs) related from FAERS database spanning January 1, 2004, September 30, 2023. compiled frequently reported based on frequency of events. employed detection methodologies ascertain whether these elicited significant signals, including reporting odds ratio, proportional multi-item gamma Poisson shrinker, information component given by Bayesian confidence propagation neural network. Furthermore, we conducted a time-to-onset (TTO) analysis for generating signals using medians, quartiles, Weibull shape parameter test. Results total 50, 659, 288 ADEs, among which 169,897 (0.34%) were constipation. selected ranked drugs. The highest ranking was lenalidomide (7,730 cases, 4.55%), prevalent class being antineoplastic immunomodulating agents. Signal performed drugs, risk identified 26 them. Among 22 exhibited consistent those listed FDA-approved labels. However, four (orlistat, nintedanib, palbociclib, dimethyl fumarate) presented an unexpected Ranked values, sevelamer carbonate emerged as strongest [reporting ratio (95% CI): 115.51 (110.14, 121.15); PRR (χ 2 ): 83.78 (191,709.73); EBGM (EB05): 82.63 (79.4); IC (IC025): 6.37 (4.70)]. A TTO that generated revealing all early failure type. median orlistat 3 days, shortest while clozapine 1,065 longest Conclusion Our study provides list potentially drug-induced (DIC). could inform clinicians about some alternative medications consider when managing secondary causes or caring patients prone DIC, thereby reducing incidence mortality DIC.

Language: Английский

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Mechanisms of Oral Ciprofloxacin-Induced Depressive-Like Behavior and the Potential Benefit of Lactulose: A Correlation Analysis

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101920 - 101920

Published: Jan. 21, 2025

Language: Английский

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Different Efficacy of Five Soluble Dietary Fibers on Alleviating Loperamide-Induced Constipation in Mice: Influences of Different Structural Features

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1236 - 1236

Published: Jan. 31, 2025

Different dietary fibers have distinct structures, leading to significant variations in their laxative effects. To explore how these structural differences impact constipation intervention, a 14-day study was conducted on loperamide-induced constipated mice using five fibers: soluble fiber from steamed sweet potato (SDF-S), oat β-glucan (OB), polydextrose (PD), arabinogalactan (AG), and inulin (IN). The results showed that four fibers, excluding PD, significantly improved gastrointestinal (GI) transit rate (p < 0.05), although PD had the highest fecal moisture, it different lowest IN 0.05). AG resulted higher 6 h weights compared other fibers. SDF-S OB were more effective modulating serum levels of hormones. monosaccharide compositions glycosidic bonds led changes gut microbiota composition SCFA profiles. Galactose arabinose linked increased abundance Lachnospiraceae_UCG-006, Bacteroides, Odoribacter, promoting butyrate fermentation, which is positively correlated with GI rate. Glucose SDF-S, OB, favored acetate fermentation moisture. Fructose encouraged proliferation Muribaculaceae_unclassified Ruminococcus, associated stool weight, respectively. β-glycosidic may lead high production through selective Lachnospiraceae_unclassified. Minor components like fucose, rhamnose, ribose Oscillospiraceae_unclassified, Anaerotignum, In conclusion, unique bond selectively promote fiber-degrading butyrate-producing bacteria, resulting varied effects relief.

Language: Английский

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Weizmannia coagulans BC99 Relieves Constipation Symptoms by Regulating Inflammatory, Neurotransmitter, and Lipid Metabolic Pathways: A Randomized, Double-Blind, Placebo-Controlled Trial

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 654 - 654

Published: Feb. 15, 2025

Probiotics have attracted increasing attention due to their benefits in terms of relieving gastrointestinal ailments, including constipation. This study evaluated the potential Weizmannia coagulans BC99 for clinical remission constipation adults. In this randomized, double-blind, and placebo-controlled trial, 90 individuals with were divided between a placebo group an 8-week intervention duration. The spontaneous bowel movement (SBM) frequency, patient assessment symptoms (PAC-SYM), quality life (PAC-QOL), inflammatory cytokines, neurotransmitters, serum metabolites investigated before after intervention. results showed that significantly improved adults constipation, as evidenced by increased SBM score decreased PAC-SYM PAC-QOL scores. Additionally, supplementation levels neurotransmitters (5-HT, MTL, AChE, BDNF) associated intestinal motility alleviated inflammation participants supported higher anti-inflammatory factors (IL-4, IL-10) lower pro-inflammatory (IL-6, IFN-γ) group. Furthermore, altered abundance 93 affected biological pathways correlated motility, sphingolipid metabolism, steroid hormone biosynthesis, glycerophospholipid metabolism. demonstrates effectiveness W. strain adults, reveals its mechanism action. These findings provide scientific basis effective safe probiotic treatment.

Language: Английский

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Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 27, 2024

Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety (AXD) constipation. However, no consensus has been reached regarding their interdependence pathogenesis. Herein, we sought to further explore the causal associations between them. Bidirectional two-sample Mendelian randomization (MR) analysis was performed confirm link MDD, AXD Genetic instrumental variables for AXD, constipation were obtained from publicly available genome-wide association (GWASs). In this MR analysis, inverse variance weighting (IVW) used as primary method evaluate effect. Additionally, employed Cochran's Q test, MR‒Egger intercept MR-PRESSO examine heterogeneity pleiotropy. Moreover, leave-one-out investigate stability of associations. Finally, a reverse conducted. The results revealed relationship MDD an increased risk (p = 0.0001), whereas 8.52 × 10–1) did not increase found (constipation MDD: p 9.37 10–1; AXD: 8.51 10–1). This study genetic evidence supporting

Language: Английский

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