Appraising the role of biotics and fermented foods in gut microbiota modulation and sleep regulation

Journal of Food Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Abstract Sleep disturbances are increasingly prevalent, significantly impacting physical and mental health. Recent research reveals a bidirectional relationship between gut microbiota sleep, mediated through the microbiota–gut–brain axis. This review examines role of in sleep physiology explores how biotics, including probiotics, prebiotics, synbiotics, postbiotics, fermented foods, can enhance quality. Drawing from animal human studies, we discuss neurobiological mechanisms by which biotics may influence modulation neurotransmitters, immune responses, hormonal regulation. Key microbial metabolites, such as short‐chain fatty acids, highlighted for their supporting sleep‐related neurochemical processes. Additionally, this presents dietary strategies food processing technologies, like fermentation, innovative approaches enhancement. Although promising, available has limitations, small sample sizes, variability biotic strains dosages, reliance on subjective assessments. underscores need standardized protocols, objective assessments polysomnography, personalized interventions. Emerging findings highlight therapeutic potential improvement, though further large‐scale trials essential to refine strain selection, dosage, formulation. interdisciplinary exploration seeks advance food‐based interventions holistic managing disorders improving quality life.

Language: Английский

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Comparative Analysis of Sleep Deprivation Models: Impacts on Sleep Architecture, Emotional State, Cognitive Function, and Biochemical Indicators in Male Rats

Behavioural Brain Research, Journal Year: 2025, Volume and Issue: 482, P. 115451 - 115451

Published: Jan. 29, 2025

Language: Английский

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Postbiotics Made From Selected Lactic Acid Bacteria Improves Chronic Restraint Stress‐Induced Anhedonia and Sleep Disorders

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Sleep disorders have become one of the most prevalent neuropsychiatric in recent years. This study aimed to investigate effects postbiotics derived from selected lactic acid bacteria on anhedonia and sleep chronic restraint stress (CRS)-induced mice, as well their potential mechanisms. Mice were orally administered normal saline, low, medium, or high doses for 30 days, with CRS applied days 1 21. The medium dose significantly increased sucrose preference index, duration. Postbiotic treatment effectively restored diversity composition gut microbiota levels comparable those observed vehicle (Veh) group. Furthermore, low reduced serum corticosterone levels, IL-1β levels. Additionally, administration glutamate GABA both prefrontal cortex hypothalamus, feces. These results indicate that alleviate CRS-induced a dose-dependent manner. effect may be mediated through restoration homeostasis MGB axis, HPA inflammation pathways, neurotransmitter balance.

Language: Английский

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The role of molecular weight on chitosan and chitosan oligosaccharides in sleep regulation: Integrating network pharmacology and multi-omics analysis in Drosophila

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142147 - 142147

Published: March 1, 2025

Language: Английский

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An analysis of electroacupuncture as adjunctive treatment for insomnia: a new perspective targeting GABA-mediated microbiome-gut-brain axis

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 30, 2025

Introduction Insomnia is a prevalent psychiatric disorder that significantly impacts mental and physical health. Emerging evidence suggests gut microbiota, particularly γ-aminobutyric acid (GABA) producing bacteria, plays critical role in the microbiome-gut-brain axis (MGBA), influencing sleep states. Electroacupuncture (EA) has been shown to have favorable anti-insomnia effects. This research protocol outlines randomized controlled trial (RCT) designed investigate efficacy of EA modulating GABA levels via MGBA alleviate insomnia. Methods analysis The study will use glutamate (Glu) concentrations p-chlorophenylalanine (PCPA) -induced insomnia rat model examine whether at specific acupoints can increase brain plasma by enhancing abundance GABA-producing bacteria. A second experiment transplant stool from rats into germ-free mice evaluate causal microbiota pathology. Primary outcome measures include changes Glu levels, data about open field test, composition. Discussion provide insights therapeutic mechanisms targeting treatment contribute development novel strategies. Ethics dissemination approved Laboratory Animal Center Xiamen University (No. XMULAC20220100). findings be submitted for publication peer-reviewed academic journals.

Language: Английский

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Jinhua Hecha – A fermented green tea improves sleep via regulating glutamatergic synapses and gut microbiota

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 123, P. 106550 - 106550

Published: Nov. 13, 2024

Language: Английский

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