Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 12, 2025
Hidradenitis suppurativa (HS) is a chronic, inflammatory and common skin disease. Observation studies have reported the association between HS cancers, however no whether causal relationship exists cancers. This study aimed to explore differential subtypes of cancers by conducting bidirectional Mendelian randomization (MR) analysis. Genome-wide (GWAS) data related 16 were collected. The inverse variance weighted (IVW) method was primarily applied for our MR analysis, MR-Egger, median, simple mode, mode methods used additionally. Heterogeneity, horizontal pleiotropy, potential outliers assessed analysis results. Subsequently, disease-related genes retrieved from GeneCards database. To investigate functions these associated genes, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses conducted. results indicated pancreatic cancer (PAC). Specifically, found elevate risk developing PAC (odds ratio (OR), 1.074; 95% confidence interval (CI) 1.015–1.135; p = 0.013). Conversely, reverse demonstrated that does not exert effect on HS. Furthermore, findings did reveal any significant relationships other types cancer. No evidence heterogeneity or pleiotropy identified in Additionally, we subsequent GO KEGG both are implicated pathways with immune processes. this offer novel regarding HA PAC. Our indicates may influence PAC, which could inform development improved treatment strategies patients suffering However, underlying mechanisms warrant further exploration.
Language: Английский