Inguinal hernia mesh infections: Chronic challenges, atypical pathogens and lessons in sterilisation

Tropical Doctor, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Chronic mesh infections after inguinal hernia repair present significant clinical challenges due to biofilm-mediated resistance, involvement of multidrug-resistant and atypical pathogens, gaps in preventive strategies. Our case series four patients highlights critical research gaps, including the overlooked role pathogens such as Mycobacterium tuberculosis, diagnostic detecting slow-growing or resistant organisms perioperative sterilisation lapses, especially inconsistent Glutaraldehyde use during late-day operations. Many suffered with persistent sinuses recurrent hernias months surgery. Microbiological analyses identified Pseudomonas aeruginosa, Klebsiella pneumoniae, tuberculosis mixed flora. Complete removal culture-directed antimicrobial therapy resolved all cases within 8–12 months. study underscores need for robust protocols, advanced measures biofilm-resistant biomaterials.

Language: Английский

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Effects of Combined Shinbaro and Celecoxib in a Complete Freund’s Adjuvant-Induced Inflammatory Pain Mouse Model

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2349 - 2362

Published: Feb. 1, 2025

Persistent inflammation resulting from injury, infection, or arthritis contributes to both peripheral and central sensitization. Various combinations of natural extracts have been explored minimize the side effects associated with conventional medications. Shinbaro, which has traditionally used in Eastern medicine treat inflammatory conditions, was chosen due its known anti-inflammatory properties. However, previous studies not yet investigated combined administration celecoxib Shinbaro for their analgesic effects. In this study, we examined combining a complete Freund's adjuvant (CFA)-induced pain model. We randomly assigned 66 mice 6 groups (n = 11 per group) administered intraplantar injections 100 μL CFA saline into right hind paw, followed by oral (100 mg/kg), (15 30 minutes later. Behavioral assessments were conducted blindly at baseline on days 1, 3, 7 post-injection. The paw spinal cord harvested 3 post-injection examine molecular mechanisms, including macrophage infiltration as well glial cell activation cytokine levels cord. Statistical analysis performed using Tukey's post-hoc test. combination mg/kg) synergistically reduced mechanical hyperalgesia edema preventing conversion monocytes macrophages inhibiting infiltration. Moreover, it decreased expression pro-inflammatory cytokines mediators microglial activation. demonstrates significant effects, suggesting potential managing fewer than therapies.

Language: Английский

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Analysis of Potential Factors Influencing Baicalin Content in Scutellaria baicalensis from Different Regions

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(4)

Published: April 1, 2025

Objective: This study explored the effects of climatic and soil factors on baicalin accumulation in Scutellaria baicalensis , aiming to compare content antibacterial efficacy across regions optimize cultivation practices. Methods: S. samples were collected from three production areas Shanxi, Inner Mongolia, Hebei. Baicalin total protein contents measured, sample differences explored. The microbial community composition was determined, analyzed. Results: highest Hebei, with no significant difference content. most effective effect achieved a 100 mg/mL concentration Hebei solution. positively correlated annual average temperature, precipitation, relative humidity negatively sunshine hours wind speed. Shanxi's rhizosphere contained higher levels nitrogen, carbon, sulfur, nitrate, nitrite compared other regions. S0134 terrestrial group Longimicrobiaceae associated Conclusion: exhibited superior quality, influenced by ecological factors. In order improve effect, quality can be improved selecting planting suitable acidity alkalinity, adjusting ratio phosphorus, potassium fertilizers moderately during cultivation, appropriate amount water, fully utilizing active compounds medicinal plants microorganisms.

Language: Английский

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Combinatorial Effects of Ursodeoxycholic Acid and Antibiotic in Combating Staphylococcus aureus Biofilm: The Roles of ROS and Virulence Factors

Microorganisms, Journal Year: 2024, Volume and Issue: 12(10), P. 1956 - 1956

Published: Sept. 27, 2024

is a biofilm-forming bacterium responsible for various human infections, one particularly challenging to treat due its antibiotic resistance. Biofilms can form on both soft tissues and medical devices, leading persistent hard-to-treat infections. Combining multiple antimicrobials potential approach overcoming this This study explored the effects of ursodeoxycholic acid (UDCA) combined with ciprofloxacin against

Language: Английский

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BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection

Journal of Materials Science, Journal Year: 2024, Volume and Issue: 59(41), P. 19628 - 19641

Published: Oct. 24, 2024

Language: Английский

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Combination therapy of natural products for the treatment of ESKAPE pathogens

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 2

Published: Nov. 6, 2024

Language: Английский

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Bacteriological Profile, Antibiotic Susceptibility, and Biofilm Formation in Children with Chronic Suppurative Otitis Media

International Journal of Pediatric Otorhinolaryngology, Journal Year: 2024, Volume and Issue: 188, P. 112208 - 112208

Published: Dec. 22, 2024

Language: Английский

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