Fungal Diversity and Interactions in the Nasal and Oral Cavities of Individuals with Allergic Rhinitis, Asthma and Healthy Controls DOI Creative Commons
Marcos Pérez‐Losada

Microorganisms, Journal Year: 2025, Volume and Issue: 13(6), P. 1204 - 1204

Published: May 25, 2025

Allergic rhinitis and asthma are common chronic airway diseases that present significant public health challenges. Previous research has shown how the nasal oral mycobiomes influence onset, progression severity of these two conditions, but no study so far directly compared those within same cohort during disease. To address this gap, I analyzed next-generation fungal ITS sequence data from 349 participants, including individuals with allergic rhinitis, asthma, healthy controls. The showed a great overlap in composition differed significantly (p < 0.04) relative abundance several dominant genera. Moreover, only 18.6% amplicon variants were shared among cavities. Microbial alpha-diversity was higher 0.05) cavity, while beta-diversity varied 0.045) across all indices clinical groups. Fungal networks largely fragmented relatively low ecological niche specialization, which contrasts previous bacteriomes cohort. These also structure, complexity keystone nodes phenotypes. Overall, findings highlight play distinct yet interconnected roles asthma.

Language: Английский

Diversity and Interactions of the Naso-Buccal Bacteriome in Individuals with Allergic Rhinitis, Asthma and Healthy Controls DOI Creative Commons
Marcos Pérez‐Losada

Allergies, Journal Year: 2025, Volume and Issue: 5(2), P. 16 - 16

Published: May 12, 2025

Allergic rhinitis and asthma are significant public health concerns worldwide. While previous studies have explored how nasal buccal bacteriotas influence these conditions, few directly compared their bacteriomes within the same cohort. To bridge this gap, I analyzed 16S rRNA next-generation sequencing data from 347 individuals, including participants with allergic rhinitis, healthy controls. The shared all dominant bacterial taxa but differed significantly in phylum- genus-level relative abundances. Alpha-diversity was higher cavity, while beta-diversity varied across indices clinical groups. Over 80% of predicted metabolic pathways were differentially regulated between two cavities, yet functional differences remained fairly consistent Naso-buccal networks exhibited striking structure, complexity hub nodes. Notably, network controls showed a clear segregation bacteria, 93.5% interactions occurring each respective contained pathogenic keystone taxa. In contrast, diseased individuals reduced ecological specialization more linked to airway disease. These findings, thus, demonstrate that naso-buccal bacteriome plays distinct interconnected roles asthma.

Language: Английский

Citations

1
Asthma und allergische Rhinitis: Erhebliche Pilzbesiedlung im Vergleich zur gesunden Bevölkerung DOI

Miriam Sonnet

Deutsches Ärzteblatt, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Citations

0
Different Phenotypes of Pediatric Asthma Show Distinct Bacterial Functional Profiles and Network Relationships DOI Creative Commons
Marcos Pérez‐Losada

Allergies, Journal Year: 2025, Volume and Issue: 5(2), P. 14 - 14

Published: May 6, 2025

Pediatric asthma is the most common chronic childhood disease in US and a major public health concern. It considered to comprise multiple clinical variants or phenotypes with different etiologies pathophysiologies. Former research has shown that airway bacteriomes vary composition structure across pediatric phenotypes, but their functional diversity bacterial interactions have hardly been investigated. A previous study of 163 children from Washington DC identified three statistically each unique nasopharyngeal diversity. Here, I reanalyze 16S rRNA high-throughput sequences same cohort characterize metabolism interactions. detect 61 102 metabolic pathways (PICRUSt2; q ≤ 0.05) differentially expressed phenotypes. Most those are related biosynthesis degradation processes (p 0.0012) separated groups. Co-occurrence networks also differ connectivity suggesting group. Five eight keystone taxa detected Insights this studies, hence, confirm bacteriome heterogeneity asthma, increasing our understanding its etiology pathophysiology, provide new taxonomic biomarkers for targeted interventions therapies.

Language: Английский

Citations

0
Fungal Diversity and Interactions in the Nasal and Oral Cavities of Individuals with Allergic Rhinitis, Asthma and Healthy Controls DOI Creative Commons
Marcos Pérez‐Losada

Microorganisms, Journal Year: 2025, Volume and Issue: 13(6), P. 1204 - 1204

Published: May 25, 2025

Allergic rhinitis and asthma are common chronic airway diseases that present significant public health challenges. Previous research has shown how the nasal oral mycobiomes influence onset, progression severity of these two conditions, but no study so far directly compared those within same cohort during disease. To address this gap, I analyzed next-generation fungal ITS sequence data from 349 participants, including individuals with allergic rhinitis, asthma, healthy controls. The showed a great overlap in composition differed significantly (p < 0.04) relative abundance several dominant genera. Moreover, only 18.6% amplicon variants were shared among cavities. Microbial alpha-diversity was higher 0.05) cavity, while beta-diversity varied 0.045) across all indices clinical groups. Fungal networks largely fragmented relatively low ecological niche specialization, which contrasts previous bacteriomes cohort. These also structure, complexity keystone nodes phenotypes. Overall, findings highlight play distinct yet interconnected roles asthma.

Language: Английский

Citations

0