An Overview of Sarcopenia: Focusing on Nutritional Treatment Approaches
M. Barone,
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Palmina Baccaro,
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Alessio Molfino
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et al.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(7), P. 1237 - 1237
Published: April 1, 2025
Sarcopenia
is
a
syndrome
characterized
by
the
progressive
and
generalized
loss
of
skeletal
muscle
mass
strength.
This
condition
associated
with
physical
disability,
decreased
quality
life,
increased
mortality.
Therefore,
reducing
prevalence
sarcopenia
could
significantly
lower
healthcare
costs.
can
be
classified
into
primary
secondary
sarcopenia.
The
former
related
to
aging
begins
after
fourth
decade
life;
that,
there
around
8%
per
until
age
70
years,
which
subsequently
increases
15%
decade.
On
other
hand,
affect
all
individuals
may
result
from
various
factors
including
inactivity,
malnutrition,
endocrine
disorders,
neurodegenerative
diseases,
inflammation,
cachexia.
Understanding
multiple
mechanisms
involved
in
onset
progression
allows
for
us
develop
strategies
that
prevent,
treat,
or
at
least
mitigate
caused
protein
breakdown.
One
potential
treatment
based
on
nutritional
interventions,
adequate
caloric
intake
specific
nutrients
support
health.
Such
include
natural
food
rich
whey
omega-3
fatty
acids
as
well
supplements
like
branched-chain
amino
acids,
β-hydroxy-β-methylbutyrate,
vitamin
D
along
special
medical
purposes.
It
important
emphasize
exercises,
especially
resistance
training,
not
only
promote
synthesis
their
own
but
also
work
synergistically
enhance
effectiveness.
Language: Английский
Mechanisms of microbial-gut-brain axis modulation by electroconvulsive therapy in the treatment of depression
Jiaming Ji,
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Jun Guo,
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Jirong Yang
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et al.
Anesthesiology and Perioperative Science,
Journal Year:
2025,
Volume and Issue:
3(2)
Published: May 7, 2025
Abstract
Purpose
The
present
study
aims
to
evaluate
the
effects
of
electroconvulsive
therapy
(ECT)
on
depressive
behaviors.
In
addition,
we
explore
mechanisms
by
which
ECT
alters
composition
and
functioning
gut
microbiota
through
microbiota-gut-brain
axis.
Methods
A
depression
model
in
mice
was
established
using
chronic
unpredictable
mild
stress.
were
divided
into
three
groups:
control,
depression,
ECT-treated.
Depressive
behaviors
assessed
a
series
behavioral
tests,
including
monitoring
body
weight,
open
field
sucrose
preference
forced
swim
tests.
Histological
microcirculatory
assessments
brain
tissues
conducted
hematoxylin
eosin
(H&E)
staining,
Nissl
staining
immunofluorescence
methodology
along
with
laser
speckle
contrast
imaging.
inflammatory
cytokines
Tumor
Necrosis
Factor-
α
(TNF-
),
Interleukin-6
(IL-6)
Interleukin-1
β
(IL-1
)
quantified
enzyme-linked
immunosorbent
assay.
Metagenomic
sequencing
employed
diversity
abundance
microbiota.
Results
significantly
improved
as
evidenced
increased
weight
decreased
immobility
time
H&E
indicated
substantial
reduction
inflammation
while
revealed
restoration
neuronal
morphology
following
treatment.
Furthermore,
analysis
showed
elevated
c-Fos
expression
hippocampal
region
(
P
<
0.05).
Assessments
demonstrated
significant
reductions
TNF-
,
IL-6,
IL-1
levels
group.
metagenomic
that
enhanced
diversity,
particularly
restoring
Bacteroides
Verrucomicrobia
Conclusion
exerts
its
antidepressant
modulating
enhancing
functionality
gut-brain
Language: Английский