Potential relationship of the gut microbiome with testosterone level in men: a systematic review DOI Creative Commons
Cennikon Pakpahan, Geraldo Laurus,

Markus Christian Hartanto

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19289 - e19289

Published: April 15, 2025

The gut microbiome influences the metabolism and health of several organs beyond has recently gained considerable attention. plays a central role in food digestion, absorption, nutrition, general health. Hence, become research subject for almost all conditions. Imbalance or dysbiosis can cause different issues men, including reproductive sexual associated with testosterone levels. Several studies have investigated relationship between In this systematic review, we aimed to examine levels men. Literature searches were conducted by scanning PubMed, ProQuest, EBSCO, Taylor & Francis Online, Wiley Springer Link, Web Science, Google Scholar, Science Direct databases relevant keywords following preferred reporting items review guidelines. This included cross-sectional, case-control, retrospective, prospective cohort studies. Quality assessment was using Newcastle-Ottawa Scale. We found significant positive correlation microbes play substantial roles production. Mechanisms been proposed as factors that contribute levels, namely hypothalamus-pituitary-gonad axis modulation, androgen metabolism, intestinal homeostasis, balancing bone morphogenic protein (BMP) Wnt diverse microbiome. Ruminococcus showed stronger than other microorganisms. complex correlations metabolism. However, most influence on cannot be easily identified requires further research.

Language: Английский

A PRISMA Systematic Review of Sexual Dysfunction and Probiotics with Pathophysiological Mechanisms DOI Creative Commons

Su-Jin Yang,

Trang Thi Minh Nguyen, Xiangji Jin

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 286 - 286

Published: March 11, 2025

Sexual dysfunction, influenced by hormonal imbalances, psychological factors, and chronic diseases, affects a significant portion of the population. Probiotics, known for their beneficial effects on gut microbiota, have emerged as potential therapeutic agents improving sexual health. This systematic review evaluates impact probiotics function, regulation, reproductive outcomes. A comprehensive search identified 3308 studies, with 12 meeting inclusion criteria—comprising 10 randomized controlled trials (RCTs) 2 in vivo vitro studies. Probiotic interventions were shown to significantly improve particularly women undergoing antidepressant therapy (p < 0.05). Significant improvements Female Function Index (FSFI) scores observed, combined treatments such Lactofem Letrozole selective serotonin reuptake inhibitors (SSRIs) demonstrating 10% biochemical clinical pregnancy rate compared 0% control group = use was also associated 66% reduction menopausal symptoms, increased sperm motility (36.08%), viability (46.79%), morphology (36.47%). Probiotics contributed favorable changes, including reduced luteinizing hormone (LH) follicle-stimulating (FSH) ratio (from 3.0 2.5, p 0.05) testosterone levels. Regarding outcomes, probiotic higher rates fertility motility, viability, men. highlights promising role addressing dysfunction health, suggesting adjunctive conditions depression infertility. Further research is needed better understand underlying mechanisms these effects.

Language: Английский

Citations

0
Effects of chitosan on restoring spermatogenesis in mice: Insights from gut microbiota and multi-omics analysis DOI

Guitian He,

Boqi Zhang, Tong Chen

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116218 - 116218

Published: March 15, 2025

Language: Английский

Citations

0
Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research DOI Creative Commons
Wenkang Chen, Hede Zou, Haoran Xu

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Aging biomarkers quantify aging progression and provide actionable targets for therapeutic interventions to mitigate age-related decline. This review synthesizes emerging evidence on testicular biomarkers, focusing cellular senescence (Leydig, Sertoli, endothelial cells), protein homeostasis disruption, mitochondrial dysfunction, germ stem cell depletion, sperm telomere length, epigenetic alterations, oxidative stress, inflammation, gut microbiota dysbiosis. We propose that serves as a critical nexus linking reproductive decline with systemic processes, its pathological being quantifiable through specific including the Leydig, cells, INSL3, ribosomal RPL39L, relative length translocator protein, sialic acid. By bridging paradigms testis-specific mechanisms, we emphasize urgency identify organ-selective targeted interventions, advancing strategies preserve male fertility address population challenges.

Language: Английский

Citations

0
Mechanisms of Hormonal, Genetic, and Temperature Regulation of Germ Cell Proliferation, Differentiation, and Death During Spermatogenesis DOI Creative Commons
María Maroto,

Sara Nuñez Torvisco,

Cristina García-Merino

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 500 - 500

Published: March 29, 2025

Spermatogenesis is a complex and highly regulated process involving the proliferation, differentiation, apoptosis of germ cells. This controlled by various hormonal, genetic, environmental factors, including temperature. In hormonal regulation, follicle-stimulating hormone (FSH), luteinizing (LH), testosterone (T) are essential for correct spermatogenesis development from early stages spermatogonia proliferation to cell maturation. Other hormones, like inhibin activin, finely participate tuning spermatogenesis. Genetic regulation involves transcription such as SOX9, SRY, DMRT1, which crucial maintenance testis MicroRNAs (miRNAs) play significant role regulating gene expression post-transcriptionally. Epigenetic modifications, DNA methylation, histone chromatin remodelling, also vital. Temperature another critical aspect, with testicular temperature maintained around 2-4 °C below body temperature, efficient Heat shock proteins (HSPs) protect cells heat-induced damage acting molecular chaperones, ensuring proper protein folding preventing aggregation misfolded during thermal stress. Elevated can impair spermatogenesis, increasing inducing oxidative stress, damage, disruption blood-testis barrier, leading death impaired differentiation. The cellular mechanisms include mitotic divisions maintain pool produce spermatocytes. Spermatocytes undergo meiosis haploid spermatids, then differentiate into mature spermatozoa. Apoptosis, or programmed death, ensures removal defective regulates population. Hormonal imbalance, genetic defects, stress trigger Understanding these addressing male infertility developing therapeutic interventions. Advances in biology genetics continue uncover intricate details how at multiple levels, providing new insights potential targets treatment.

Language: Английский

Citations

0
Therapeutic potential of microbiome modulation in reproductive cancers DOI
Mega Obukohwo Oyovwi, Benneth Ben‐Azu,

Kehinde Henrietta Babawale

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(5)

Published: April 6, 2025

Language: Английский

Citations

0
Potential relationship of the gut microbiome with testosterone level in men: a systematic review DOI Creative Commons
Cennikon Pakpahan, Geraldo Laurus,

Markus Christian Hartanto

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19289 - e19289

Published: April 15, 2025

The gut microbiome influences the metabolism and health of several organs beyond has recently gained considerable attention. plays a central role in food digestion, absorption, nutrition, general health. Hence, become research subject for almost all conditions. Imbalance or dysbiosis can cause different issues men, including reproductive sexual associated with testosterone levels. Several studies have investigated relationship between In this systematic review, we aimed to examine levels men. Literature searches were conducted by scanning PubMed, ProQuest, EBSCO, Taylor & Francis Online, Wiley Springer Link, Web Science, Google Scholar, Science Direct databases relevant keywords following preferred reporting items review guidelines. This included cross-sectional, case-control, retrospective, prospective cohort studies. Quality assessment was using Newcastle-Ottawa Scale. We found significant positive correlation microbes play substantial roles production. Mechanisms been proposed as factors that contribute levels, namely hypothalamus-pituitary-gonad axis modulation, androgen metabolism, intestinal homeostasis, balancing bone morphogenic protein (BMP) Wnt diverse microbiome. Ruminococcus showed stronger than other microorganisms. complex correlations metabolism. However, most influence on cannot be easily identified requires further research.

Language: Английский

Citations

0