Antitubercular activity of silver(I) complexes with 7-chloro-4-aminoquinolines: synthesis, characterization and in vitro biological assays DOI
Kaíque Alexandre D’Oliveira,

Isabela O. Souza,

Nícolas Glanzmann

et al.

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 9, 2025

This article describes the synthesis, characterization, and biological activity of four quinoline derivatives, ACQ12, ACQ13, ACQ14, ACQophen, their respective silver(I) complexes. The organic compounds are composed 4,7-dichloroquinoline derivatives containing aliphatic diamines, 1,2-ethanediamine (ACQ12), 1,3-propanediamine (ACQ13), 1,4-butanediamine (ACQ14), an aromatic diamine, o-phenylenediamine (ACQophen), as a side chain at 4-position ring. crystalline structure ACQophen was solved by single crystal X-ray diffraction, while structures Ag-ACQ12 (1), Ag-ACQ13 (2), Ag-ACQ14 (3), Ag-ACQophen (4) were obtained polycrystals diffraction technique. Silver complexes have shown 1:1 (M:L) molar ratio. Further characterization in all performed analytical methods spectroscopic techniques. Elemental analyses, conductometry IR, Raman UV–Vis spectroscopies confirmed proposed molecular formulas. Coordination occurs through nitrogen atom Biological assays vitro for synthesized against Mycobacterium tuberculosis H37Rv American Type Collection Culture 27294 (ATCC 27294). Free aminoquinolines 3 4 showed MIC90 below 13.0 mg L−1. selectivity index (SI) over 190 its Ag(I) complex has SI = 3.09, making these promising antimycobacterial agents.

Language: Английский

Antitubercular activity of silver(I) complexes with 7-chloro-4-aminoquinolines: synthesis, characterization and in vitro biological assays DOI
Kaíque Alexandre D’Oliveira,

Isabela O. Souza,

Nícolas Glanzmann

et al.

Journal of Coordination Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 9, 2025

This article describes the synthesis, characterization, and biological activity of four quinoline derivatives, ACQ12, ACQ13, ACQ14, ACQophen, their respective silver(I) complexes. The organic compounds are composed 4,7-dichloroquinoline derivatives containing aliphatic diamines, 1,2-ethanediamine (ACQ12), 1,3-propanediamine (ACQ13), 1,4-butanediamine (ACQ14), an aromatic diamine, o-phenylenediamine (ACQophen), as a side chain at 4-position ring. crystalline structure ACQophen was solved by single crystal X-ray diffraction, while structures Ag-ACQ12 (1), Ag-ACQ13 (2), Ag-ACQ14 (3), Ag-ACQophen (4) were obtained polycrystals diffraction technique. Silver complexes have shown 1:1 (M:L) molar ratio. Further characterization in all performed analytical methods spectroscopic techniques. Elemental analyses, conductometry IR, Raman UV–Vis spectroscopies confirmed proposed molecular formulas. Coordination occurs through nitrogen atom Biological assays vitro for synthesized against Mycobacterium tuberculosis H37Rv American Type Collection Culture 27294 (ATCC 27294). Free aminoquinolines 3 4 showed MIC90 below 13.0 mg L−1. selectivity index (SI) over 190 its Ag(I) complex has SI = 3.09, making these promising antimycobacterial agents.

Language: Английский

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