Threats across boundaries: the spread of ESBL-positive Enterobacteriaceae bacteria and its challenge to the “one health” concept DOI Creative Commons

Shaqiu Zhang,

Jing Yang, Muhammad Abbas

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

β-lactam antibiotics are essential medications for treating human diseases. The spread of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) exists globally in multiple reservoirs and the natural environment poses an immense threat to public health. Plasmid incompatibility groups, such as IncFIA, IncI1, IncY, IncFIB, IncN, IncFIC, IncX4, IncB/O/K/Z, IncHI1/2, IncA/C, which exist humans, animals, environment, carrying bla CTX-M, TEM, SHV genes. ISEcp1 upstream orf477 downstream CTX-M genes, well other mobile genetic elements (MGEs) IS903 IS26, involved capturing mobilizing antibiotic-resistant genes (ARGs). CTX-M-15 gene is most common among all discussed reservoirs. environmental reservoir propagation mode ESBL-PE increasing difficult control. reasons include but not limited bacterial adaptability horizontal transfer (HGT) mediated by MGEs plasmids. Conjugation a pathway HGT that almost uncontrollable. plasmids Tn3, IS1380 families, IncK, IncN facilitating This review highlights need monitor trends antimicrobial resistance (AMR) environment. Therefore, policies antibiotic management plans, training healthcare providers and/or patients, cautious use antibiotics, epidemiological networks, pre-travel consultations, World Health Organization (WHO) infection control biosafety guidelines, intervention measures considered desirable.

Language: Английский

Threats across boundaries: the spread of ESBL-positive Enterobacteriaceae bacteria and its challenge to the “one health” concept DOI Creative Commons

Shaqiu Zhang,

Jing Yang, Muhammad Abbas

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 21, 2025

β-lactam antibiotics are essential medications for treating human diseases. The spread of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) exists globally in multiple reservoirs and the natural environment poses an immense threat to public health. Plasmid incompatibility groups, such as IncFIA, IncI1, IncY, IncFIB, IncN, IncFIC, IncX4, IncB/O/K/Z, IncHI1/2, IncA/C, which exist humans, animals, environment, carrying bla CTX-M, TEM, SHV genes. ISEcp1 upstream orf477 downstream CTX-M genes, well other mobile genetic elements (MGEs) IS903 IS26, involved capturing mobilizing antibiotic-resistant genes (ARGs). CTX-M-15 gene is most common among all discussed reservoirs. environmental reservoir propagation mode ESBL-PE increasing difficult control. reasons include but not limited bacterial adaptability horizontal transfer (HGT) mediated by MGEs plasmids. Conjugation a pathway HGT that almost uncontrollable. plasmids Tn3, IS1380 families, IncK, IncN facilitating This review highlights need monitor trends antimicrobial resistance (AMR) environment. Therefore, policies antibiotic management plans, training healthcare providers and/or patients, cautious use antibiotics, epidemiological networks, pre-travel consultations, World Health Organization (WHO) infection control biosafety guidelines, intervention measures considered desirable.

Language: Английский

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