Generation of Population-Level Diversity in Anaplasma phagocytophilum msp2/p44 Gene Repertoires Through Recombination DOI Creative Commons
Anthony F. Barbet, David R. Allred, Francy L. Crosby

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 233 - 233

Published: Feb. 27, 2025

Anaplasma phagocytophilum, a tick-borne Rickettsiales, causes an emerging disease among humans and animals called granulocytic anaplasmosis. The organism expresses immunodominant surface protein, MSP2/P44, that undergoes rapid antigenic variation during single infections due to gene conversion at genomic expression site with sequences from one of ~100 transcriptionally silent genes known as “functional pseudogenes”. Most studies have indicated the predominant mechanism is insertion complete central variable regions (CVRs) into msp2/p44 via homologous recombination through 5′ 3′ conserved regions. This suggests it possible persistent by strain may be self-limiting exhaustion repertoire. However, if there substantial within functional pseudogene repertoires themselves, likely these high rate change. was investigated here analyzing pseudogenes in genome-sequenced A. phagocytophilum widely different geographic locations USA Europe. data strongly support probability events having occurred between not limited CVR, greatly expanding total potential variation. Continual predicted aid overcoming existing immunity individual causing superinfections immune populations, this facilitate adaptation microorganism infect cause species.

Language: Английский

Generation of Population-Level Diversity in Anaplasma phagocytophilum msp2/p44 Gene Repertoires Through Recombination DOI Creative Commons
Anthony F. Barbet, David R. Allred, Francy L. Crosby

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 233 - 233

Published: Feb. 27, 2025

Anaplasma phagocytophilum, a tick-borne Rickettsiales, causes an emerging disease among humans and animals called granulocytic anaplasmosis. The organism expresses immunodominant surface protein, MSP2/P44, that undergoes rapid antigenic variation during single infections due to gene conversion at genomic expression site with sequences from one of ~100 transcriptionally silent genes known as “functional pseudogenes”. Most studies have indicated the predominant mechanism is insertion complete central variable regions (CVRs) into msp2/p44 via homologous recombination through 5′ 3′ conserved regions. This suggests it possible persistent by strain may be self-limiting exhaustion repertoire. However, if there substantial within functional pseudogene repertoires themselves, likely these high rate change. was investigated here analyzing pseudogenes in genome-sequenced A. phagocytophilum widely different geographic locations USA Europe. data strongly support probability events having occurred between not limited CVR, greatly expanding total potential variation. Continual predicted aid overcoming existing immunity individual causing superinfections immune populations, this facilitate adaptation microorganism infect cause species.

Language: Английский

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