NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer DOI Open Access
Justyna Klusek, Piotr Lewitowicz, Oblap Rv

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(4), P. 937 - 937

Published: Feb. 6, 2024

Background: The NOS2 gene polymorphism rs2297518 is associated with an increased level of NO, which could contribute to colorectal cancer (CRC) development. We hypothesized that the potential influence on development may vary between right-sided and left-sided colon cancers, rectal cancers. aim this study was determine regard tumor localization. Methods: This case-control included 199 patients CRC 120 controls. qPCR endpoint genotyping conducted using TaqMan® assay. Results: revealed significant differences in characteristic minor alelle A frequency genotype cancers different localizations. mucinous adenocarcinoma diagnosed significantly more often than (30.6% vs. 10.9%, p = 0.009) 7.1%, 0.0003). allele observed frequently (44.9% 23.1%, 0.0137) (40.0% 0.0285). Conclusions: In conclusion, results support hypothesis SNP influences

Language: Английский

A novel PCDscore based on programmed cell death-related genes can effectively predict prognosis and therapy responses of colon adenocarcinoma DOI

Yangjie Peng,

Cheng Ouyang, Yijun Wu

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 170, P. 107933 - 107933

Published: Jan. 5, 2024

Language: Английский

Citations

2
NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer DOI Open Access
Justyna Klusek, Piotr Lewitowicz, Oblap Rv

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(4), P. 937 - 937

Published: Feb. 6, 2024

Background: The NOS2 gene polymorphism rs2297518 is associated with an increased level of NO, which could contribute to colorectal cancer (CRC) development. We hypothesized that the potential influence on development may vary between right-sided and left-sided colon cancers, rectal cancers. aim this study was determine regard tumor localization. Methods: This case-control included 199 patients CRC 120 controls. qPCR endpoint genotyping conducted using TaqMan® assay. Results: revealed significant differences in characteristic minor alelle A frequency genotype cancers different localizations. mucinous adenocarcinoma diagnosed significantly more often than (30.6% vs. 10.9%, p = 0.009) 7.1%, 0.0003). allele observed frequently (44.9% 23.1%, 0.0137) (40.0% 0.0285). Conclusions: In conclusion, results support hypothesis SNP influences

Language: Английский

Citations

1