Circ_0003945: an emerging biomarker and therapeutic target for human diseases DOI Creative Commons
Xiaofei Zhang, Li Ma, Li Wan

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 22, 2024

Due to the rapid development of RNA sequencing techniques, a circular non-coding (ncRNA) known as RNAs (circRNAs) has gradually come into focus. As distinguished member circRNA family, circ_0003945 garnered attention for its aberrant expression and biochemical functions in human diseases. Subsequent studies have revealed that could regulate tumor cells proliferation, migration, invasion, apoptosis, autophagy, angiogenesis, drug resistance, radio resistance through molecular mechanism competitive endogenous (ceRNA) during tumorigenesis. The is frequently associated with some clinical parameters implies poorer prognosis majority cancers. In non-malignant conditions, also holds considerable importance diseases pathogenesis. This review aims recapitulate elucidates potential diagnostic therapeutic target neoplasms other

Language: Английский

Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer DOI Creative Commons
Cihat Erdoğan, İlknur Süer, Murat Kaya

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0301995 - e0301995

Published: April 18, 2024

Breast cancer (BC) is the most common among women with high morbidity and mortality. Therefore, new research still needed for biomarker detection. GSE101124 GSE182471 datasets were obtained from Gene Expression Omnibus (GEO) database to evaluate differentially expressed circular RNAs (circRNAs). The Cancer Genome Atlas (TCGA) Molecular Taxonomy of International Consortium (METABRIC) databases used identify significantly dysregulated microRNAs (miRNAs) genes considering Prediction Analysis Microarray classification (PAM50). circRNA-miRNA-mRNA relationship was investigated using Cancer-Specific CircRNA, miRDB, miRTarBase, miRWalk databases. circRNA–miRNA–mRNA regulatory network annotated Ontology (GO) analysis Kyoto Encyclopedia Genes Genomes (KEGG) pathway database. protein-protein interaction constructed by STRING visualized Cytoscape tool. Then, raw miRNA data filtered some selection criteria according a specific expression level in PAM50 subgroups. A bottleneck method utilized obtain highly interacted hub cytoHubba plugin. Disease-Free Survival Overall performed these genes, which are detected within circRNA axis our study. We identified three circRNAs, miRNAs, eighteen candidate target that may play an important role BC. In addition, it has been determined molecules can be useful BC, especially determining basal-like breast (BLBC) subtype. conclude hsa_circ_0000515/miR-486-5p/SDC1 distinguishing patients BLBC subgroup

Language: Английский

Citations

6
Uncovering the regulatory roles of miR-4319 in tumour progression DOI
Zhi Xiong Chong

Human Gene, Journal Year: 2024, Volume and Issue: 41, P. 201312 - 201312

Published: Sept. 1, 2024

Language: Английский

Citations

0
Profiling mRNA and miRNA expression variations associated with cyclin-dependent kinase pathway in the low-grade luminal early breast cancer DOI

Amir Mahdi Khamaneh,

Nasrin Mohajeri,

Behrooz Naghili

et al.

Journal of Applied Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Language: Английский

Citations

0
Deciphering the Roles of Non-Coding RNAs in Liposarcoma Development: Challenges and Opportunities for Translational Therapeutic Advances DOI Creative Commons
Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 11, P. 73 - 90

Published: Nov. 15, 2024

Liposarcoma is one of the most prevalent forms soft tissue sarcoma, and its prognosis highly dependent on molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) long non-coding (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting expressions activities their downstream post-transcriptionally, dysregulations miRNAs alter different oncogenic signalling pathways, mediating liposarcoma progression. On contrary, lncRNAs sponge spare from translational repression, indirectly miRNA-regulated activities. In past 15 years, multiple fundamental clinical research has shown that ncRNAs play essential roles in modulating development. Yet, there a lack an effective review report could summarize findings studies. To narrow this literature gap, article aimed compare studies tumour-regulatory understand how control progression mechanistically. Additionally, reported were critically reviewed evaluate potentials applications, including employing these as diagnostic prognostic biomarkers or therapeutic management liposarcoma. Overall, over apoptosis, WNT/β-catenin, TGF-β/SMAD4, EMT, interleukin, YAP-associated pathways influence 28 be upregulated tissues circulation, whereas 11 downregulated, making them potential candidates biomarkers. Among ncRNAs, measuring circulating levels miR-155 miR-195 was help detect liposarcoma, differentiate subtypes, predict survival treatment response patients. except for few miR-195, current evidence support use discussed managing mainly based single-center study with relatively small sample sizes cell-based Hence, more large-scale multi-center should conducted further confirm sensitivity, specificity, safety targets. Instead furthering investigation values all which time- cost-consuming, it would practical focus if they are sensitive safe used agents

Language: Английский

Citations

0
Determination of the Possible Target Genes of Hepatoma-derived Growth Factor in Hepatoma Cells DOI Open Access
Hirayuki Enomoto, Takashi Nishimura,

SHINYA FUKUNUSHI

et al.

In Vivo, Journal Year: 2023, Volume and Issue: 37(5), P. 1975 - 1979

Published: Jan. 1, 2023

Background/Aim: We identified a new growth factor, hepatoma-derived factor (HDGF), which is presumed growth-stimulating of hepatocellular carcinoma (HCC). Recently, we two microRNAs (miR-6072 and miR-3137) induced by HDGF, were also found to be associated with the prognosis HCC patients. This study aimed identify target genes these HDGF-related microRNAs. Materials Methods: A public database was searched for candidate Using microarray system, whose expression changed in response HDGF administration determined. Finally, cancer genomics that HCC. Results: total 1,132 as common 2 Among genes, system showed 6 increased (≥1.5-fold) or decreased (≤0.67-fold) after administration. database, six related high alkylglycerone phosphate synthase (AGPS) significantly poor survival (p=0.0025, 0.0063 0.0081 1-, 3- 5-year survival, respectively). shroom family member 4 (SHROOM4) gene better (p=0.003, 0.0006 Conclusion: potential

Language: Английский

Citations

1
Circ_0003945: an emerging biomarker and therapeutic target for human diseases DOI Creative Commons
Xiaofei Zhang, Li Ma, Li Wan

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 22, 2024

Due to the rapid development of RNA sequencing techniques, a circular non-coding (ncRNA) known as RNAs (circRNAs) has gradually come into focus. As distinguished member circRNA family, circ_0003945 garnered attention for its aberrant expression and biochemical functions in human diseases. Subsequent studies have revealed that could regulate tumor cells proliferation, migration, invasion, apoptosis, autophagy, angiogenesis, drug resistance, radio resistance through molecular mechanism competitive endogenous (ceRNA) during tumorigenesis. The is frequently associated with some clinical parameters implies poorer prognosis majority cancers. In non-malignant conditions, also holds considerable importance diseases pathogenesis. This review aims recapitulate elucidates potential diagnostic therapeutic target neoplasms other

Language: Английский

Citations

0