Advances in Materials Science,
Journal Year:
2023,
Volume and Issue:
23(4), P. 99 - 122
Published: Dec. 1, 2023
Abstract
Carbonaceous
or
nanocarbon
nano-reinforcement
nanocomposites
have
been
found
as
emergent
candidates
for
aerospace
industry.
Consequently,
the
multifunctional
fabricated
using
marvelous
nanostructures
like
graphene,
carbon
nanotube,
fullerene,
black,
etc.
Manufacturing
techniques
also
engrossed
formation
of
high
performance
engineering
having
fine
strength,
heat
stability,
flame
resistance,
and
other
space
desired
features.
These
practices
include
solution,
in
situ,
melt
procedures,
on
top
specific
structural
design
techniques,
structures.
The
related
material
property
enhancements
various
carbonaceous
nano-reinforcements
depends
upon
type
nanocarbon,
dimensionality,
well
inherent
features
these
(in
addition
to
choice
manufacturing
methods).
Furthermore,
filled,
besides
fibers,
epoxy
matrices.
Nanocarbon
coated
fibers
filled
resins
form
nanomaterials
materials
experiential
appropriate
Further
research
may
be
a
key
towards
future
opportunities
aero
systems.
Additionally,
explorations
structure-property
relationships
indispensable
development
advanced
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: June 13, 2024
Combination
therapy
with
oral
administration
of
several
active
ingredients
is
a
popular
clinical
treatment
for
cancer.
However,
the
traditional
method
has
poor
convenience,
less
safety,
and
low
efficiency
patients.
The
combination
pharmaceutical
techniques
advanced
material
conversion
methods
can
provide
new
solutions
to
this
issue.
In
research,
kind
hybrid
film
was
created
via
coaxial
electrospraying,
followed
by
casting
process.
films
were
composed
Reglan
5-fluorouracil
(5-FU)-loaded
cellulose
acetate
(CA)
core-shell
particles
in
polyvinylpyrrolidone
(PVP)
matrix.
Microscopic
observations
these
demonstrated
solid
cross
section
loaded
particles.
X-ray
diffraction
Fourier-transform
infrared
tests
verified
that
5-FU
showed
amorphous
states
fine
compatibilities
polymeric
matrices,
i.e.,
PVP
CA,
respectively.
vitro
dissolution
indicated
able
desired
asynchronous
dual-drug
delivery,
fast
release
Reglan,
sustained
5-FU.
controlled
mechanisms
shown
be
an
erosion
mechanism
typical
Fickian
diffusion
protocols
reported
herein
pioneer
approach
fabricating
biomaterials
multiple
drugs,
each
its
own
behavior,
synergistic
cancer
treatment.
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(17), P. 8573 - 8582
Published: Jan. 1, 2024
Janus
nanoparticles
with
soluble
polyvinylpyrrolidone
patches
located
on
the
insoluble
Eudragit
RL100
sides
were
prepared
using
a
side-by-side
electrospraying
method
and
are
demonstrated
to
provide
biphasic
release
of
paracetamol
in
turn
faster
action
longer
time
periods
blood
drug
concentration
for
therapy.
Biomolecules,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1011 - 1011
Published: June 18, 2023
In
this
nano
era,
nanomaterials
and
nanostructures
are
popular
in
developing
novel
functional
materials.
However,
the
combinations
of
materials
at
micro
macro
scales
can
open
new
routes
for
trans-scale
products
with
improved
or
even
performances.
work,
a
brand-new
hybrid,
containing
both
nanofibers
microparticles,
was
fabricated
using
sequential
electrohydrodynamic
atomization
(EHDA)
process.
Firstly,
microparticles
loaded
drug
(berberine
hydrochloride,
BH)
molecules
cellulose
acetate
(CA)
were
solution
electrospraying
Later,
these
suspended
into
co-dissolved
that
contained
BH
hydrophilic
polymer
(polypyrrolidone,
PVP)
co-electrospun
nanofiber/microparticle
hybrids.
The
EHDA
processes
recorded,
resultant
showed
typical
hybrid
topography,
distributed
all
over
nanofibers,
which
demonstrated
by
SEM
assessments.
FTIR
XRD
components
within
hybrids
presented
an
amorphous
state
had
fine
compatibility
each
other.
vitro
dissolution
tests
verified
able
to
provide
designed
dual-step
release
profiles,
combination
fast
step
from
PVP
through
erosion
mechanism
sustained
insoluble
CA
via
Fickian
diffusion
mechanism.
present
protocols
pave
way
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(9), P. 2314 - 2314
Published: Sept. 13, 2023
Smart
drug
delivery,
through
which
the
molecules
are
delivered
according
to
requests
of
human
biological
rhythms
or
by
maximizing
therapeutic
effects,
is
highly
desired
in
pharmaceutics.
Many
biomacromolecules
have
been
exploited
for
this
application
past
few
decades,
both
industry
and
laboratories.
Biphasic
release,
with
an
intentional
pulsatile
release
a
following
extended
stage,
represents
typical
smart
delivery
approach,
aims
provide
fast
action
long
time
period
effective
blood
concentration
patients.
In
study,
based
on
use
well-known
biomacromolecule,
i.e.,
cellulose
acetate
(CA),
as
(acetaminophen,
ATP)-based
sustained
carrier,
modified
coaxial
electrospraying
process
was
developed
fabricate
new
kind
core–shell
nanoparticle.
The
nanoparticles
were
able
furnish
ATP
due
shell
polyvinylpyrrolidone
(PVP).
cost
30%
0.32
h,
whereas
particles
30.84-h
90%
loaded
ATP.
scanning
electron
microscope
transmission
results
verified
terms
their
round
surface
morphologies
obvious
double-chamber
structures.
presented
core
sections
amorphous
state
owing
its
fine
compatibility
CA
PVP.
controlled
mechanisms
suggested.
disclosed
biomacromolecule-based
process–structure–performance
relationship
can
shed
light
how
develop
sorts
advanced
nano
systems.
Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(8), P. 2146 - 2146
Published: July 30, 2023
In
this
nanotechnology
era,
nanostructures
play
a
crucial
role
in
the
investigation
of
novel
functional
nanomaterials.
Complex
and
their
corresponding
fabrication
techniques
provide
powerful
tools
for
development
high-performance
materials.
study,
advanced
micro-nanomanufacturing
technologies
composite
micro-nanostructures
were
applied
to
new
type
pharmaceutical
formulation,
aiming
achieve
rapid
hemostasis,
pain
relief,
antimicrobial
properties.
Briefly,
an
approach
combining
electrohydrodynamic
atomization
(EHDA)
technique
reversed-phase
solvent
was
employed
fabricate
beaded
nanofiber
structure
(BNS),
consisting
micrometer-sized
particles
distributed
on
nanoscale
fiber
matrix.
Firstly,
Zein-loaded
Yunnan
Baiyao
(YB)
prepared
using
solution
electrospraying
process.
Subsequently,
these
suspended
co-solvent
containing
ciprofloxacin
(CIP)
hydrophilic
polymer
polyvinylpyrrolidone
(PVP)
electrospun
into
hybrid
structural
microfibers
handheld
electrospinning
device,
forming
EHDA
product
E3.
The
fiber-beaded
morphology
E3
confirmed
through
scanning
electron
microscopy
(SEM)
images.
Fourier-transform
infrared
(FTIR)
spectroscopy
X-ray
diffraction
(XRD)
analysis
revealed
amorphous
state
CIP
BNS
membrane
due
good
compatibility
between
PVP.
dissolution
experiment
that
exhibits
fast
disintegration
properties
promotes
CIP.
Moreover,
vitro
drug
release
study
demonstrated
complete
within
1
min.
Antibacterial
assays
showed
significant
reduction
number
adhered
bacteria
BNS,
indicating
excellent
antibacterial
performance.
Compared
with
traditional
YB
powders
Chinese
herbs,
series
advantages
potential
wound
dressing.
These
include
improved
effect,
sustained
active
ingredients
from
YB,
convenient
covering
application,
which
resulted
integration
herbs
Western
medicine.
This
provides
valuable
insights
multiscale
micro-/nano-composite
materials
pioneers
developments
types
medicines
combination
herbal
medicines.
In
this
nano
era,
nanomaterials
and
nanostructures
are
popular
in
developing
novel
functional
materials.
However,
the
combinations
of
nanoproducts
with
materials
at
micro
macro
scale
can
open
new
routes
for
conceiving
an
improved
or
even
performances.
study,
a
brand-new
hybrid,
containing
both
nanofibers
particles
having
microsize,
was
fabricated
using
sequential
electrohydrodynamic
atomization
(EHDA)
process.
Firstly,
microparticles
loaded
drug
(berberine
hydrochloride,
BH)
molecules
cellulose
acetate
(CA)
were
solution
electrospraying
Later,
these
suspended
into
co-dissolved
containned
BH
hydrophilic
polymer
(polypyrrolidone,
PVP),
co-electrospun
nanofiber/microparticle
hybrids.
The
EHDA
processes
clearly
recorded,
resultant
products
showed
typical
hybrid
topography,
distributed
all
over
nanofibers,
which
demonstrated
by
SEM
assessments.
FTIR
XRD
that
components
within
hybrids
presented
amorphous
state
have
fine
compatibility
each
other.
vitro
dissolution
tests
verified
able
to
provide
designed
dula-step
release
profiles,
combination
fast
step
from
PVP
through
erosion
mechanism
sustained
insoluble
CA
via
Fickian
diffusion
mechanism.
present
protocols
pave
way
trans-scale
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 11, 2024
Irreversible
cryogenic
damage
caused
by
oocyte
vitrification
limits
its
widespread
use
in
female
fertility
preservation.
In
recent
years,
nanoparticles
(NPs)
have
gained
great
attention
as
potential
alternatives
protecting
oocytes
against
cryoinjuries.
this
paper,
a
novel
composite
nanoparticle,
poly
(lactic-co-glycolic
acid)-resveratrol
(PLGA-RES)
was
designed
to
improve
the
biocompatibility
and
sustained
release
properties
encapsulating
natural
antioxidant
RES
into
PLGA
NPs.
Firstly,
biotoxicity
oxidation
resistance
of
PLGA-RES
were
determined,
results
showed
that
had
nontoxic
effect
on
survival
during
vitro
maturation
(IVM)
(97.08%
±
0.24%
vs.
98.89%
1.11%,
p
>
0.05).
Notably,
even
increased
(65.10%
4.11%
52.85%
2.87%,
<
0.05)
blastocyst
rate
(56.13%
1.36%
40.91%
5.85%,
Moreover,
reduced
reactive
oxygen
species
(ROS)
level
(13.49
2.30
34.07
3.30,
0.01),
glutathione
(GSH)
(44.13
1.57
37.62
1.79,
0.01)
elevated
mitochondrial
membrane
(MMP)
levels
(43.10
1.81
28.52
1.25,
observed
treated
with
when
compared
control
group.
Subsequently,
role
played
systematically
evaluated.
The
addition
thawing
significantly
improved
(80.42%
1.97%
75.37%
1.3%,
Meanwhile,
GSH
(15.09
0.86
14.51
0.78,
(22.56
3.15
6.79
0.60,
decreased
(52.11
2.95
75.41
7.23,
abnormality
distribution
(25.00%
0.29%
33.33%
1.15%,
assessed
vitrified
MII
PLGA-RES.
Furthermore,
transcriptomic
analyses
demonstrated
participated
endocytosis
PI3K/AKT/mTOR
pathway
regulation,
which
verified
rescued
expression
ARRB2
ULK3
protein
after
treatment.
conclusion,
exhibited
potent
activity,
could
be
used
an
efficacious
strategy
quality
oocytes.
Advances in Materials Science,
Journal Year:
2023,
Volume and Issue:
23(4), P. 99 - 122
Published: Dec. 1, 2023
Abstract
Carbonaceous
or
nanocarbon
nano-reinforcement
nanocomposites
have
been
found
as
emergent
candidates
for
aerospace
industry.
Consequently,
the
multifunctional
fabricated
using
marvelous
nanostructures
like
graphene,
carbon
nanotube,
fullerene,
black,
etc.
Manufacturing
techniques
also
engrossed
formation
of
high
performance
engineering
having
fine
strength,
heat
stability,
flame
resistance,
and
other
space
desired
features.
These
practices
include
solution,
in
situ,
melt
procedures,
on
top
specific
structural
design
techniques,
structures.
The
related
material
property
enhancements
various
carbonaceous
nano-reinforcements
depends
upon
type
nanocarbon,
dimensionality,
well
inherent
features
these
(in
addition
to
choice
manufacturing
methods).
Furthermore,
filled,
besides
fibers,
epoxy
matrices.
Nanocarbon
coated
fibers
filled
resins
form
nanomaterials
materials
experiential
appropriate
Further
research
may
be
a
key
towards
future
opportunities
aero
systems.
Additionally,
explorations
structure-property
relationships
indispensable
development
advanced
