The road ahead for functional foods: Promising opportunities amidst industry challenges

Future Postharvest and Food, Journal Year: 2024, Volume and Issue: 1(2), P. 266 - 273

Published: June 1, 2024

Functional foods, fortified with bioactive compounds, offer health benefits beyond basic nutrition. Despite their potential, challenges such as compound instability, scalability issues, and regulatory gaps exist. This commentary explores role, market dynamics, future trends, emphasizing the need for ongoing research effective regulations. In dynamic field of nutrition science, functional foods have carved a significant niche. These which more than just nutrition, are compounds antioxidants (e.g., phenolic carotenoids, omega-3 fatty acids, some vitamins) that confer health-promoting disease-preventing properties (Barik et al., 2022; Khan 2013). The concept amalgamates principles from food pharmacology, thereby offering comprehensive approach to well-being (Granato 2020). rise in interest is driven by shift consumer preference toward natural health-enhancing products (Baker 2022a; Topolska 2021). As societies become increasingly health-conscious, there burgeoning demand can enhance health, boost performance, mitigate risk disease. trend mirrored rapid expansion market, projected witness substantial growth coming years (Vergari 2010). However, journey laboratory laden challenges. encompass technical issues related stability bioavailability hurdles, acceptance/trust. these challenges, potential realm personalized nutrition) delivery compounds) microorganisms probiotics) vast (Ahluwalia, 2021; Gupta Personalized particular, customizes dietary recommendations individual nutritional needs, holds revolutionize wellness near (Gupta capacity deliver targeted benefits, ideally suited this approach. harnessing necessitates overcoming scientific, regulatory, (Khan 2013; Nazir 2019). current landscape scientific literature, an abundance trending publications focusing on topic foods. despite wealth information available, noticeable void when it comes concise overview captures various facets gap particularly evident areas applications within industry. Accordingly, aims provide exhaustive role opportunities they present both consumers industry, exist exciting development road. It delves into effects bioactives, dynamics decline supplements preventive strategies, increasing awareness healthier products. paper also discusses space corresponding including manufacturing process, toxicity, lack clear regulations, limited data clinical translation, skepticism/awareness. concludes discussion trends effect future. Bioactive diverse group molecules (Kamiloglu Kumar 2023). They exhibit range antioxidant, anti-inflammatory, antimicrobial, antiatherogenic, antithrombotic, cardioprotective, vasodilatory Mohamed, 2015). Antioxidants, instance, known combat free radicals, implicated several different human diseases (Arshad & Ahmad, found variety fruits, herbs, spices, vegetables, cereals, legumes, chocolate, beverages like tea, coffee, or wine (Mohamed, derived plants, biologically active proteins, polyphenols, phytosterols, biogenic amines, carotenoids conditions cancer, cardiovascular diseases, diabetes (Samtiya efficacy depends bioavailability, be influenced factors matrix, processing, storage, differences (Berkel Kaşıkçı, 2023; de Freitas Queiroz Barros, Baú Betim Cazarin, Maróstica Junior, 2022). Bioavailability denotes degree speed at component (i.e., drug metabolite) absorbed systemic circulation, thus reaching its action site. Unfortunately, oral significantly impacted release plant solubility gastrointestinal fluid, permeability through intestinal epithelial cells, enzymatic chemical reactions taking place tract Barros Nonetheless, hold promise promoting preventing chronic diseases. Further yet needed fully understand influencing optimize maximum benefits. Beyond plant-derived important acknowledge animal sources microorganisms. For often fish, been widely recognized anti-inflammatory cardioprotective effects. Similarly, probiotics, beneficial microorganisms, associated improved gut immune function (Grand View Research, examples underscore diversity sources. progresses, anticipated will discovered utilized further emphasizes safety profiles, well develop systems compounds. global was valued USD 280.7 billion 2021, expand annual rate 8.5% 2022 2030 surge, has US illustrated Figure 1, number crucial elements. magnitude upcoming years. One primary drivers rising fortifying additives. aware impact physical mental well-being, seeking out not only satisfy hunger but additional led surge ingredients vitamins, minerals, fibers, acids (Hilton, 2017). Another factor contributing consciousness among consumers. With prevalence lifestyle-related rise, individuals making changes improve prevent disease (Daliri Lee, Functional/fortified added meet growing demand. aging population another critical driver market. people age, needs change, play meeting needs. calcium vitamin D help older adults maintain bone while those enriched support heart (van der Zanden, van Kleef, Wijk, Trijp, 2014). incidence Chronic disease, diabetes, cancer prevalent, diet plays prevention management properties, therefore becoming essential part strategies 2015; Essa summary, experiencing growth, additives, consumers, population, continue, expected reach new heights While supplement witnessing slowdown, categories even observing negative rates (Natarajan GR, Wróbel suggests perceived holistic Kengpol saw astronomical sales gains over past few years, see normalize. seeing first time long while, industry still good place. 10% between 2020 C cold-and-flu ingredient category were $586 million. Nevertheless, does spell doom indicates Preventive focus maintaining diet, gaining popularity (Bhargava, 2010; Control Prevention, Sharma, Luxita, Yadav, Akanksha, due (Sharma Singh, practical sustainable promotion, context healthcare costs burden (Boone-Villa 2019; contain scavenge radicals show anti-mutagenic, anti-tumor, neuroprotective certain physiological response reducing (Barik, Chowdhury, Tewari), promotion. Consumers well-being. heightened driving alternatives synthetic additives Bogue Repar, antioxidants, seen holistic, interested content 2022a). reflected probiotics. force behind equally ensure well-informed misled claims (Van Kleef 2005; Williams Ghosh, 2008). Misleading create false perceptions about lead unhealthy choices (Williams Therefore, education communication key ensuring make informed diet. Educational programs increase consumers' understanding initiatives distinguish scientifically substantiated potentially misleading (Franco-Arellano 2017; overall, said health-conscious increasing. numerous pose used change yield increases small large quantities (Bansal, Poonia, Kolluri, Vasundhara, Sharma affect taste, texture, final product. characteristics containing vegetable extracts bioactives vary depending type (Aqilah Moreover, unstable degrade during processing storage. instability result loss efficacy. example, susceptible oxidative degradation, chemically (Kandemir compromises minimizes breakdown processes substances reveal C, phenols, flavonoids, glycosides interact oxygen convective drying phase, especially elevated temperatures. interaction leads reduction high reducibility (Belwal ElGamal Thus, careful consideration control storage incorporated Scaling up production, indeed complex process meticulous planning execution. scaling simple multiplying quantities. When quantities, change. product may behave same way, so methods adjusted changed achieve desired result. peptides, foodstuffs values, face terms original bioactivity under (Hosseini specific manufacture, finished taste texture. Changes sourcing formula adjustments, operational complexities faced scale-up (Galanakis, Sutton 2016). Sourcing larger business ways. rewrite hit price point, unnecessary delays. use novel technologies require modifications existing processes, complicating (Avelar Galanakis, production necessary demand, presents Overcoming requires planning, execution, possibly assistance experts. Food encompasses multiple aspects, safe implementation hygienic proper preparation methods. extends fortification consumption provided. pursuit overlook safety. continues evolve, must remain forefront research, development, regulation efforts. Additionally, although nanoparticles promising avenue enhancing toxicity concern (Kang Rath minute particles, unique biological ways particles cannot, leading harmful (Sukhanova 2018). rigorous evaluations do health. isolated amounts, toxic concentrations (Mlozi 2020; Nana 2011). secondary metabolites produced playing defense mechanisms, reproduction systems, concentration At concentrations, adverse effects, stress, DNA damage, apoptosis, cell death, induction inflammatory responses Vilas-Boas dosage compounds/ingredients Regulations country (Birch Bonwick, Brown Chan, Heller, 2001; Hoadley, clear, universal regulations uncertainty manufacturers. far, Japan definition approval (Díaz contrast, United States Canada attempted define absence framework. Europe, European Union adopted working Europe-wide ambiguity confusion skepticism, undermining credibility On other hand, (Sato Valls well-defined framework successful ensures builds trust acceptance. Such would products, foster trust, ultimately, Several countries excelled setting benchmarks rest world. Japan, pioneer field, introducing term "FOSHU" (Foods Specified Health Use) classify Japanese government implemented stringent standards marketing Finland made strides area, Finnish Authority actively balanced States, FDA regulates conventional requirements claims. involves review provides claimed highlight importance acceptance similar measures harness full There enough valid evidence promotion (Mohanty Singhal, 2018; Samtiya demonstrated translation. refers applying discoveries gleaned laboratory, clinical, studies (Homer-Vanniasinkam Tsui, 2012; Mlozi More how body validate precise mechanisms exert understood (de Kang Furthermore, depend presence Wijesekara Xu, hinder professionals Healthcare hesitant recommend robust supporting skeptical if perceive backed solid 2022b). our 2022a, Baker 2021) rapidly, skepticism remains doubt fueled (Topolska Van 2005). suggest correlation intake possible advantages. globally accepted influences amount proof required assertions across nations. themselves adequate proof; comprehend significance underpins assertions. differing views regarding actual Some believe primarily promoted strategy rather customers/consumers (English, Vergari labels promote criticized (Siro 2008; observations done better inform linked consuming underscores transparent manufacturers production: mentioned earlier (Section 3.2), (Subramanian Anandharamakrishnan, Regulatory uncertainties: stated Section 3.4, (Brown Díaz 2001). Grand Need investment development: development. includes developing conducting trials (Heller, Homer-Vanniasinkam 2012). grow, companies likely enter To date, nations, corporations BASF, Cargill, General Mills Inc., GFR Pharma, Nutri-Nation, Amway, Arla Foods appear channeling resources endeavors undertaking strategic measures, fortify standing edge expansion, propelled merely momentary trend, reflection broader societal attitudes educated path manufacturing, data, all hurdles overcome. multidisciplinary brings together researchers, regulators, looks promising. Advancements technology paving way innovative solutions, approaches production. Simultaneously, helping build foundation field. one thing clear: we continue explore safe, sustainable, accessible all. open dialogue stakeholders. concerted efforts, truly live Ali Rashidinejad: Conceptualization; investigation; funding acquisition; writing - draft; methodology; validation; editing; software; project administration; resources. author declares no competing financial interest. Data sharing applicable article created analyzed.

Language: Английский

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A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119363 - 119363

Published: Jan. 1, 2025

Language: Английский

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Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review

Published: June 27, 2024

Traditional medicine systems worldwide utilize natural products (NPs), including plant-derived compounds, minerals, and organisms, harnessing their healing potential. NPs offer a rich source of potential drug candidates, driving innovation in discovery. Recent breakthroughs have reignited interest the therapeutic benefits compounds. Clinical applications NP-based immunotherapies, such as curcumin resveratrol cancer treatment, highlight diverse pharmacological properties. However, despite these advancements, challenges persist clinical implementation NPs. Issues standardization, regulatory approval, supply sustainability remain significant hurdles. Overcoming limitations requires concerted effort to address complexities NP development. Nevertheless, ongoing research efforts interdisciplinary collaboration hold promise for advancing therapeutics, paving way development innovative treatments various diseases. In world precision medicine, new chapter unfolds join journey. The exploration sources bioactive compounds has revealed promising prospects therapeutics medicine. This article explores within context It examines intricate pathways through which derived from nature tailored prospects, emphasizing role interventions. Exploring synergy between at molecular level, this delineates exciting prospect customized treatments, signifying transformative impact on modern medical care. review further highlights tailoring based individual genetic makeup disease characteristics. Additionally, it discusses addressing issues sourcing, scalability, considerations realize full

Language: Английский

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Diversity of amyloid beta peptide actions

Reviews in the Neurosciences, Journal Year: 2024, Volume and Issue: 35(4), P. 387 - 398

Published: Jan. 28, 2024

Fibril formation by amyloidogenic proteins and peptides is considered the cause of a number incurable diseases. One most known amyloid diseases Alzheimer's disease (AD). Traditionally, beta Aβ40 Aβ42 (Aβs) are as main causes AD foremost targets in fight. The efforts pharmacology aimed at reducing Aβs concentration to prevent their accumulation, aggregation, senile plaques, neuronal death, neurodegeneration. However, publications have demonstrated certain beneficial physiological effects Aβs. Simultaneously, it indicated that turn into pathological due development body. accumulation C- N-terminal truncated under diverse conditions supposed play role development. significance transformation glutamate residue positions 3 or 11 catalyzed glutaminyl cyclase making them more degradation resistant, hydrophobic, prone well participation dipeptidyl peptidase IV these transformations discussed. experimental data presented confirm maintenance physiological, nonaggregated state plant preparations. In conclusion, this review suggests fight against AD, instead removing Aβs, preference should be given treatment common Glutaminyl can treatment. Flavonoids preparations possess antiamyloidogenic propensity proposed neuroprotective, anticancer, antidiabetic food additives.

Language: Английский

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