Multi-target anti-inflammatory and cytotoxic activities of flavonoids from Varthemia iphionoides Boiss. & C. I. Blanche

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: May 2, 2025

Chronic inflammation plays a central role in the onset of many diseases, whereas long-term use anti-inflammatory drugs is often associated with harmful side effects. This study examined and cytotoxic effects seven flavonoids isolated from Varthemia iphionoides Boiss. & C. I. Blanche: jaceidin (1), kumatakenin (2), 4'-hydroxy-3,5,6,7-tetramethoxyflavone (3), santin (4), quercetin-3,3'-dimethyl ether (5), viscosine (6), isokaempferide (7). Compounds 1, 5 6 showed potent inhibition ROS (IC50 µM: 1.0, 1.7, 11.4 whole blood; 7.4, <0.3, 9.9 PMNs, respectively). All compounds, except compound 2, reduced NO• production (IC50: 9.1-26.9 µM). 3, selectively inhibited COX-1. Most compounds exhibited low toxicity BJ fibroblasts, selective cytotoxicity against HeLa cancer cells. These findings highlight multi-targeted potential flavonoids, particularly 5, as promising lead for research inflammation-related including cancer.

Language: Английский

Dammarane-Type 3,4-seco-Triterpenoid from Silver Birch (Betula pendula Roth) Buds Induces Melanoma Cell Death by Promotion of Apoptosis and Autophagy

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4091 - 4091

Published: Aug. 29, 2024

Despite unquestionable advances in therapy, melanoma is still characterized by a high mortality rate. For years, expectations have been raised compounds of natural origin as component pharmacotherapy, particularly triterpenes found the bark birch trees. In this study, 3,4-

Language: Английский