Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2187 - 2187
Published: Oct. 30, 2024
Well-annotated gene and genomic sequences serve as a foundation for making inferences in molecular biology evolution can directly impact public health. The first SARS-CoV-2 genome was submitted to the GenBank database hosted by U.S. National Center Biotechnology Information used develop two successful vaccines. Conserved protein domains are often chosen targets developing antiviral medicines or Mutation substitution patterns provide crucial information not only on functional motifs genome/protein interactions but also characterizing phylogenetic relationships among viral strains. These patterns, together with collection time of samples, basis addressing question when where host-switching event occurred. Unfortunately, undergo little quality control, critical annotation is frequently changed without being recorded. Researchers have no choice hold blind faith authenticity sequences. There been reports incorrect report that casts doubt themselves because it seems theoretically impossible identify may be authentic. This paper takes an innovative approach show some genomes cannot possibly Specifically, deposited times 2023 2024, isolated from saliva, nasopharyngeal, sewage, stool, identical reference (NC_045512). probability such occurrence effectively 0. I compile sample times. One led astray bioinformatic analysis aware errors sequence annotation.
Language: Английский