Reproductive Medicine and Biology,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Jan. 1, 2024
Abstract
Purpose
Spermatogenesis
requires
a
large
amount
of
energy,
which
is
primarily
produced
by
the
mitochondrial
electron
transfer
chain.
Mitochondrial
dysfunction
affects
male
infertility,
suggesting
relationship
between
chain
and
infertility.
COXFA4L3
(C15ORF48)
an
emerging
subunit
protein
cytochrome
oxidase
specifically
expressed
in
germ
cells
during
spermatogenesis,
it
may
be
involved
Therefore,
to
investigate
whether
could
marker
sperm,
this
study
examined
expression
localization
profile
sperm
patients
with
Methods
Twenty‐seven
semen
samples
from
infertility
clinic
at
Reproductive
Center
Yokohama
City
University
Medical
were
used
analyze
quality
parameters
energy
production‐related
proteins.
These
data
compared
outcomes
treatment.
Results
The
levels
varied
significantly
samples.
Furthermore,
was
ectopically
localized
acrosome.
Conclusions
Ectopic
PNA‐stained
acrosomes
useful
for
fertility
treatment
selection.
Assessing
acrosomal
will
expedite
pregnancy
planning.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 30, 2024
Abstract
Glucagon-like
peptide-1
receptor
(GLP-1R)
agonists
(GLP-1RAs)
ameliorate
mitochondrial
health
by
increasing
its
turnover
and
improving
quality
control.
While
the
GLP-1R
is
well
known
to
stimulate
cAMP
production
leading
activation
of
Protein
Kinase
A
(PKA)
Exchange
Activated
cyclic
AMP
2
(Epac2)
signalling,
there
a
lack
understanding
molecular
mechanisms
linking
GLP-1RA-induced
signalling
with
remodelling
improved
function.
Here
we
present
dataset
that
demonstrates
that,
following
GLP-1RA
stimulation
in
pancreatic
β-cells,
interacts
endoplasmic
reticulum
(ER)
membrane
contact
site
(MCS)
organising
factor
VAP-B
from
an
endocytic
location
engage
SPHKAP,
A-kinase
anchoring
protein
(AKAP)
associated
type
diabetes
(T2D)
adiposity
genome-wide
association
studies
(GWAS),
trigger
pool
mitochondrially
localised
PKA
phosphorylates
cristae
organizing
system
(MICOS)
complex
component
MIC19,
enabling
optimal
β-cell
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
ABSTRACT
Activation
of
innate
immune
signaling
occurs
during
the
progression
immunometabolic
diseases,
including
type
2
diabetes
(T2D),
yet
impact
on
glucose
homeostasis
is
controversial.
Here,
we
report
that
E3
ubiquitin
ligase
TRAF6
integrates
signals
following
diet-induced
obesity
to
promote
through
induction
mitophagy.
Whereas
was
dispensable
for
and
pancreatic
β-cell
function
under
basal
conditions,
pivotal
insulin
secretion,
mitochondrial
respiration,
increases
in
mitophagy
metabolic
stress
both
mouse
human
islets.
Indeed,
critical
recruitment
machinery
within
ubiquitin-mediated
(Parkin-dependent)
receptor-mediated
(Parkin-independent)
pathways
upon
stress.
Intriguingly,
effect
deficiency
fully
reversed
by
concomitant
Parkin
deficiency.
Thus,
our
results
implicate
a
role
cross-regulation
ubiquitin-
receptor-
mediated
restriction
Parkin.
Together,
illustrate
β-cells
engage
adaptively
respond
diabetogenic
environment.
Pathophysiology,
Journal Year:
2025,
Volume and Issue:
32(1), P. 9 - 9
Published: Feb. 13, 2025
Diabetes
mellitus
represents
a
complicated
metabolic
condition
marked
by
ongoing
hyperglycemia
arising
from
impaired
insulin
secretion,
inadequate
action,
or
combination
of
both.
Mitochondrial
dysfunction
has
emerged
as
significant
contributor
to
the
aetiology
diabetes,
affecting
various
processes
critical
for
glucose
homeostasis.
This
review
aims
elucidate
complex
link
between
mitochondrial
and
covering
spectrum
diabetes
types,
role
mitochondria
in
resistance,
highlighting
pathophysiological
mechanisms,
DNA
damage,
altered
biogenesis
dynamics.
Additionally,
it
discusses
clinical
implications
complications
its
complications,
diagnostic
approaches
assessing
function
diabetics,
therapeutic
strategies,
future
directions,
research
opportunities.
OMICS A Journal of Integrative Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 11, 2025
Type
2
diabetes
(T2D)
is
characterized
by
relative
insulin
deficiency
due
to
pancreatic
beta
cell
dysfunction
and
resistance
in
different
tissues.
Not
only
cells
but
also
other
islet
(alpha,
delta,
polypeptide
[PP])
are
critical
for
maintaining
glucose
homeostasis
the
body.
In
this
overarching
context
given
that
a
deeper
understanding
of
T2D
pathophysiology
novel
molecular
targets
much
needed,
studies
integrate
experimental
computational
biology
approaches
offer
veritable
prospects
innovation.
study,
we
report
on
single-cell
RNA
sequencing
data
integration
with
generic
Human1
model
generate
context-specific
genome-scale
metabolic
models
alpha,
beta,
PP
nondiabetic
states
and,
importantly,
at
resolution.
Moreover,
flux
balance
analysis
was
performed
investigation
activities
cells.
By
altering
oxygen
uptakes
networks,
documented
ways
which
hypoglycemia,
hyperglycemia,
hypoxia
led
changes
various
cellular
subsystems.
Reporter
metabolite
revealed
significant
transcriptional
around
several
metabolites
involved
sphingolipid
keratan
sulfate
metabolism
alpha
cells,
fatty
acid
myoinositol
phosphate
delta
Taken
together,
leveraging
modeling,
research
bridges
gap
between
theory
clinical
practice,
offering
comprehensive
framework
advance
our
T2D,
contributes
new
knowledge
toward
development
targeted
precision
medicine
interventions.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 7, 2025
Mitochondria
play
a
central
role
in
cellular
energy
production,
metabolic
regulation,
and
oxidative
stress
management.
Their
dysfunction
is
hallmark
of
cardiometabolic
diseases,
including
obesity,
diabetes,
metabolic-associated
steatotic
liver
disease
(MASLD),
cardiovascular
(CVD).
Mitochondrial
decline,
characterized
by
impaired
phosphorylation,
excessive
reactive
oxygen
species
(ROS)
mitochondrial
DNA
(mtDNA)
mutations,
also
accelerates
aging
contributes
to
senescence
dysregulation.
This
chapter
explores
the
essential
health
diseases
aging,
focusing
on
emerging
therapeutic
strategies
restore
function.
Therapeutic
fasting,
intermittent
fasting
caloric
restriction,
has
shown
significant
potential
enhance
mitophagy,
promote
biogenesis,
improve
efficiency.
Concurrently,
natural
supplements
such
as
resveratrol,
curcumin,
spermidine,
green
tea
polyphenols
vitamins
have
demonstrated
efficacy
mitigating
stress,
preserving
mtDNA
integrity,
supporting
electron
transport
chain
activity.
highlights
mechanisms
addressing
dysfunction,
offering
innovative
approaches
manage
extend
healthspan,
combat
aging-related
disorders.
The
discusses
challenges
future
directions
for
translating
these
findings
into
clinical
practice.
Journal of Pineal Research,
Journal Year:
2025,
Volume and Issue:
77(3)
Published: April 1, 2025
ABSTRACT
Human
dental
pulp
stem
cells
(hDPSCs)
exhibit
amazing
therapeutic
abilities
in
a
variety
of
diseases
due
to
their
remarkable
self‐renewal
capacity
and
multi‐differentiation
potential.
However,
potential
could
be
weakened
by
various
factors
such
as
oxidative
stress
cell
survival
microenvironment
In
Vivo.
Here,
we
explored
the
protective
effect
mechanism
melatonin
(Mel)
on
hDPSCs
transplanted
type
1
diabetes
mellitus
(T1DM)
rat
model.
Nicotinamide
adenine
dinucleotide
(NAD
+
)
metabolism
mitochondrial
function
were
remarkably
impaired
T1DM
rats
caused
stress,
while
combination
Mel
post‐hDPSCs
transplantation
rebalance
NAD
homeostasis
through
regulating
NAMPT‐NAD
‐SIRT1
axis.
Furthermore,
significantly
reduced
intracellular
reactive
oxygen
species,
alleviated
senescence
apoptosis
exposed
hydrogen
peroxide
ameliorating
depletion
dysfunction.
The
role
extremely
essential
tissue
engineering
regenerative
medicine.
