Dual-Pathway Targeted Therapy for Parkinson's Disease: Biomimetic Nanosomes Inhibit Ferroptosis and Pyroptosis Through NLRP3 Inflammasome Regulation DOI
Yiping Wang,

Qinglong Guo,

Heng Zhang

et al.

Published: Jan. 1, 2025

Language: Английский

Advances in the structures, mechanisms and targeting of molecular chaperones DOI Creative Commons

Jinying Gu,

Yanyi He, Chenxi He

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 12, 2025

Abstract Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention protein misfolding and abnormal aggregation, modulation homeostasis, protection cells from damage under constantly changing environmental conditions. As understanding biological mechanisms molecular chaperones has increased, their link with occurrence progression disease suggested that these proteins are promising targets for therapeutic intervention, drawing intensive interest. Here, we review recent advances determining structures heat shock 90 (HSP90) chaperone system complexes. We also describe features shed light on complicated mechanism operates through interactions various co-chaperones cycles. In addition, how affect diseases by regulating pathogenic been thoroughly analyzed. Furthermore, focus to systematically discuss clinical drug design strategies preclinical stage. Recent studies have identified variety novel targeting systems compounds act different those traditional inhibitors. Therefore, as more developed, will significantly contribute discovery new potential drugs.

Language: Английский

Citations

1
The differential roles of heat shock protein 90 isoforms in skin inflammation: Anti-inflammatory potential of TRAP1 inhibition DOI
Hakim Ben Abdallah, Lars Iversen, Claus Johansen

et al.

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Lithospermic acid targeting heat shock protein 90 attenuates LPS-induced inflammatory response via NF-кB signalling pathway in BV2 microglial cells DOI Creative Commons
Jie Guo, Chenguang Li,

Feng-yi Mai

et al.

Immunologic Research, Journal Year: 2025, Volume and Issue: 73(1)

Published: Feb. 19, 2025

Language: Английский

Citations

0
Dual-Pathway Targeted Therapy for Parkinson's Disease: Biomimetic Nanosomes Inhibit Ferroptosis and Pyroptosis Through NLRP3 Inflammasome Regulation DOI
Yiping Wang,

Qinglong Guo,

Heng Zhang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0