Association between protein intake and sources in mid-pregnancy and the risk of gestational diabetes mellitus

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 6, 2025

This study aimed to investigate the relationship between dietary protein intake and sources in second trimester of pregnancy risk gestational diabetes mellitus (GDM) further effects total animal on GDM. A case-control was conducted, which involved 947 pregnant women from three hospitals Jiangsu, China. Dietary assessed using a 3-day 24-hour recall food frequency questionnaire. Two models (leave-one-out partition models) nutritional epidemiology were used for substitution analysis, logistic regression performed explore relationships, adjusting multiple confounding factors. After factors, negatively correlated with GDM (OR [95% CI], 0.10 [0.04-0.27]; P<0.001). Animal also risk, but this became insignificant when calorie, carbohydrate fat added as covariates analysis (0.68 [0.34-1.34]; P = 0.263). No association found plant GDM(1.04 [0.69-1.58]; 0.852). Replacing carbohydrates an equal energy ratio(5% intake) protein, respectively reduced by 45%, 46% 51%. The especially eggs, dairy products, fish, can reduce while consuming unprocessed red meat increases risk. There is no significant intakes processed meat, poultry occurrence results are expected provide basis precise education, health guidance during pregnancy, early prevention

Language: Английский

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Research on the application effect of self-transcendence nursing model in patients with gestational diabetes mellitus: a randomised controlled trial

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 25, 2025

Language: Английский

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Microbiome and Pregnancy Dysbiosis: A Narrative Review on Offspring Health

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1033 - 1033

Published: March 15, 2025

Background: Emerging evidence suggests that the maternal microbiome plays a crucial role in shaping fetal neurodevelopment, immune programming, and metabolic health. Dysbiosis during pregnancy—whether gastrointestinal, oral, or vaginal—can significantly influence pregnancy outcomes long-term child Materials Methods: The search was performed using databases such as PubMed, Scopus, Google Scholar including research published from January 2000 to 2025. keywords used were “Fetal Programming”, “ Maternal Immune Activation”, “Maternal microbiome”, “Microbiota–Gut–Brain Axis”, “Pregnancy Dysbiosis”. Results: undergoes substantial changes pregnancy, with alterations microbial diversity function linked conditions gestational diabetes, obesity, preeclampsia. Pregnancy-related dysbiosis has been associated adverse neurodevelopmental outcomes, an increased risk of autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), cognitive impairments offspring. Conclusions: Understanding intricate relationship between microbiota health is essential for developing targeted interventions. Personalized microbiome-based strategies, dietary modifications probiotic supplementation, hold promise optimizing promoting

Language: Английский

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Effects of Prebiotic Phytocompound Administration in Gestational Diabetic Dams and Its Influence on Offspring Cognitive Outcomes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3140 - 3140

Published: March 28, 2025

Gestational diabetes mellitus (GD)-induced gut dysbiosis in pregnant mothers may increase the risk of cognitive impairment and neurological disorders both mother offspring as they age. Restoring balance could improve outcomes for both. Despite advancements GD treatment, side effects have increased, long-term neurocognitive impacts on born to remain underexplored. This study uses a mouse model, inducing pancreatic dysfunction 3-month-old C57BL/6J mice with Streptozotocin. The efficacy mechanism prebiotic phytocompound green leaf extract (Allmania nodiflora) were assessed, metformin standard. dams exhibited weight glucose reduction, IL-6 elevation, GLUT3 astroglia changes cerebral cortex, barrier impairment, heightened anxiety compared controls. Bacterial 16s rRNA sequencing revealed dysbiosis, reduced Erysipelotrichales Metformin lowered blood levels but failed rescue functional behavioral phenotypes offspring. Phytocompound treatment improved glucose, inflammation, integrity, reversed enhanced brain health. It rescued deficits offspring, suggesting be more effective therapeutic agent humans.

Language: Английский

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Extra-Thyroidal Impacts of Serum Iodine Concentrations During Early Pregnancy on Metabolic Profiles and Pregnancy Outcomes: Prospective Study Based on Huizhou Mother–Infant Cohort

Nutrients, Journal Year: 2025, Volume and Issue: 17(10), P. 1626 - 1626

Published: May 9, 2025

Objectives: This study aimed to test the extra-thyroidal impacts of maternal serum iodine concentrations (SICs) on metabolic factors and subsequent pregnancy outcomes. Methods: Single pregnant women aged 18–49 years were recruited during their first prenatal visits. SICs at trimester (T1) tested by ICP-MS. Metabolic [body mass index (BMI), fat %, glucose, lipids, uric acid, blood pressure] measured, composite indices [the triglyceride–glucose (TyG) index, TyG-BMI, Framingham steatosis (FSI)] estimated. Obstetric birth outcomes retrieved from hospital information system, including gestational diabetes (GDM), hypertension (GH), fetal distress, postpartum hemorrhage, premature rupture membrane, small large for age (SGA LGA), preterm birth, low weight. Multivariable linear logistic regression models applied explore associations between SIC, factors, Results: A total 1456 mothers included analysis. Maternal LgSIC values T1 inversely associated with early weight gain (β = −0.113, p < 0.001) BMI −0.070, 0.006), but they positively triglycerides 0.142, 0.001), TyG 0.137, acid 0.060, 0.018). However, upon further adjustment thyroid hormones, attenuated. The joint effects high SIC conditions (hyperlipidemia, FSI, GH) suggested increased adverse (increased bleeding, reduced length, delivery weeks). Conclusions: Our prospective data in replete region indicated that risk outcomes, being independent hormones.

Language: Английский

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Association Between Gestational Diabetes Mellitus and Risk of Overall and Site-Specific Cancers (Pancreatic, Liver, Thyroid, Lung): A Systematic Review and Meta-Analysis

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 808 - 808

Published: May 19, 2025

Background: Gestational diabetes mellitus (GDM) is a common endocrine and metabolic disorder during pregnancy. However, current studies have not reached consensus on the correlation between GDM risk of developing cancers. Objective: This systematic review meta-analysis aims to comprehensively evaluate association overall cancer cancers at specific sites (pancreatic cancer, thyroid liver lung cancer). Methods: A search was conducted in PubMed, Web Science, Scopus, EMBASE, Cochrane Library databases from establishment 16 January 2025. Two researchers independently assessed quality included using Newcastle-Ottawa Scale extracted relevant data. Data were analyzed STATA Version 17.0. Results: total 8 involving 1,936,836 participants. We calculated pooled hazard ratio (HR) association, results showed that HR for 1.16 (95%CI: 1.04–1.28), indicating significant increase malignancies among patients with GDM. also significantly associated pancreatic (HR = 2.80; 95%CI: 1.20–6.55), 1.21; 1.08–1.36), 1.33; 1.10–1.61). Additionally, close being statistically 1.19; 0.98–1.44). Conclusion: Our study suggests an increased as well cancer.

Language: Английский

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Maternal Diabetes and Neurodevelopmental Outcomes of Infants Born Before 29 Weeks’ Gestation

The Journal of Pediatrics, Journal Year: 2024, Volume and Issue: unknown, P. 114319 - 114319

Published: Sept. 1, 2024

Language: Английский

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