Modifications of biological membranes, fat globules and liposomes promoted by cavitation processes. Consequences and applications DOI
Santiago Nicolás Fleite, Miryan Cassanello, Marı́a del Pilar Buera

et al.

Chemistry and Physics of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 105462 - 105462

Published: Nov. 1, 2024

Language: Английский

Retinal pharmacodynamic and pharmacokinetics profile of cannabidiol in an in vivo model of retinal excitotoxicity DOI Creative Commons
Federica Conti, Francesca Lazzara, Kyriaki Thermos

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177323 - 177323

Published: Jan. 1, 2025

Language: Английский

Citations

0
Berberine loaded glyceryl monooleate nanoparticles exhibited potent intrinsic anticancer activity against pancreatic cancer therapy: In vitro and in silico studies DOI Creative Commons

Md. Harun Al Rashid,

Sweta Mishra,

Saswati Pattnaik

et al.

Nano Trends, Journal Year: 2025, Volume and Issue: unknown, P. 100092 - 100092

Published: Feb. 1, 2025

Language: Английский

Citations

0
Localization of fluorescent gold nanoparticles throughout the eye after topical administration DOI Creative Commons
Gabrielle Raîche-Marcoux,

Sébastien Méthot,

Ange Tchatchouang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 19, 2025

The human eye is a highly intricate sensory organ. When condition requiring treatment occurs, eyedrops, which represent 90% of all ophthalmic treatments, are most frequently used. However, eyedrops associated with low bioavailability, less than 0.02% therapeutic molecules reaching the anterior chamber. Thus, new delivery systems required to ensure sufficient drug concentration over time at target site. Gold nanoparticles promising avenue for delivery; however, they can be difficult track in biological systems. Fluorescent gold nanoparticles, have same ultrastability and biocompatibility as their nonfluorescent counterpart, could act an effective imaging tool study localization throughout after administration. this (1) synthesized characterized fluorescent (2) validated similar properties between (3) determined topical application on ex vivo rabbit eyes. were synthesized, characterized, identified cornea, iris, lens, posterior segment eyeballs, demonstrating tremendous potential future research.

Language: Английский

Citations

0
Innovative approaches to treatment of eye diseases: advances in stem cell therapy use in ophthalmology DOI

Victor Oluwatomiwa Ajekiigbe,

Chinonyelum Emmanuel Agbo,

Ikponmwosa Jude Ogieuhi

et al.

International Ophthalmology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 22, 2025

Language: Английский

Citations

0
Corneal endothelial dysfunction treatments: Recent advances in non-invasive treatment strategies DOI Creative Commons
Nataliia Gnyliukh, Rabah Boukherroub, Sabine Szunerits

et al.

Nano Today, Journal Year: 2025, Volume and Issue: 63, P. 102740 - 102740

Published: April 4, 2025

Language: Английский

Citations

0
Chitosan-Stabilized Lipid Vesicles with Indomethacin for Modified Release with Prolonged Analgesic Effect: Biocompatibility, Pharmacokinetics and Organ Protection Efficacy DOI Creative Commons

Angy Abu Koush,

T. Popa, Beatrice Rozalina Bucă

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 523 - 523

Published: April 16, 2025

Background/Objectives: Indomethacin (IND) is a widely used non-steroidal anti-inflammatory drug (NSAID) effective in managing pain and inflammation. However, its therapeutic use often limited by gastrointestinal irritation low bioavailability. This study aimed to evaluate the biocompatibility, release kinetics, analgesic potential of IND-loaded chitosan (CHIT)-stabilized lipid vesicles (IND-ves) comparison free IND, focusing on their vivo effects impact somatic nociceptive reactivity mice. Methods: IND-ves were prepared using molecular droplet self-assembly technique, followed CHIT coating enhance stability control release. Mice administered either IND or IND-ves, various physiological parameters, including liver kidney function, oxidative stress markers, immune cell activity, histopathological changes key organs, assessed. Plasma kinetics evaluated tail-flick test. Results: Both demonstrated good with no significant hematological, biochemical, immunological profiles. exhibited sustained profile, initiating at 30 min peaking 3 h, while displayed rapid gastric mucosal damage. did not induce inflammation maintained organ integrity, particularly protecting against injury. Additionally, prolonged profile contributed extended Conclusions: CHIT-stabilized offer promising delivery system for enhancing release, prolonging efficacy, minimizing irritation. These findings suggest that could serve as safer more alternative NSAID therapy.

Language: Английский

Citations

0
The role of metal nanocarriers, liposomes and chitosan-based nanoparticles in diabetic retinopathy treatment: A review study DOI
Junling Liu, Feng Zhang, Xiaolong Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139017 - 139017

Published: Dec. 1, 2024

Language: Английский

Citations

1
Modifications of biological membranes, fat globules and liposomes promoted by cavitation processes. Consequences and applications DOI
Santiago Nicolás Fleite, Miryan Cassanello, Marı́a del Pilar Buera

et al.

Chemistry and Physics of Lipids, Journal Year: 2024, Volume and Issue: unknown, P. 105462 - 105462

Published: Nov. 1, 2024

Language: Английский

Citations

0