Structural Virology: The Key Determinants in Development of Antiviral Therapeutics

Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 417 - 417

Published: March 14, 2025

Structural virology has emerged as the foundation for development of effective antiviral therapeutics. It is pivotal in providing crucial insights into three-dimensional frame viruses and viral proteins at atomic-level or near-atomic-level resolution. Structure-based assessment components, including capsids, envelope proteins, replication machinery, host interaction interfaces, instrumental unraveling multiplex mechanisms infection, replication, pathogenesis. The structural elucidation enzymes, proteases, polymerases, integrases, been essential combating like HIV-1 HIV-2, SARS-CoV-2, influenza. Techniques X-ray crystallography, Nuclear Magnetic Resonance spectroscopy, Cryo-electron Microscopy, Tomography have revolutionized field significantly aided discovery ubiquity chronic infections, along with emergence reemergence new threats necessitate novel strategies agents, while extensive diversity their high mutation rates further underscore critical need analysis to aid development. This review highlights significance structure-based investigations bridging gap between structure function, thus facilitating therapeutics, vaccines, antibodies tackling emerging threats.

Language: Английский

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Light and electron microscopy of the micromorphology and development of pycniospores and aeciospores of the sunflower rust, Puccinia helianthi

Micron, Journal Year: 2024, Volume and Issue: 189, P. 103733 - 103733

Published: Nov. 16, 2024

Language: Английский

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