40Hz Auditory Entrainment Promotes Synchronization Between Frontal and Parietal Regions of the Brain DOI
Mojtaba Lahijanian, Hamid Aghajan

Published: May 9, 2023

Gamma oscillations are known to play a critical role in memory and cognition tasks. The quality of neural activity this oscillatory band is impaired due Alzheimer's disease (AD) dementia. Recently, promoting gamma through sensory stimulation has shown promising therapeutic results reducing structural cognitive symptoms AD. Further analysis on the effects entrainment brain's could help better understand mechanisms underlying observed improvements optimize protocols for achieving outcome. In study, we investigate 40Hz auditory brain synchronizing frontoparietal based electroencephalogram data recorded from cohort elderly participants with complaints. We that entrained encompasses entire scalp most responsive regions frontal parietal lobes. addition, synchronized synchronization correlated strength entrainment. other word, highly sites cortices present between these two regions. Long distance across can improve functional connectivity disrupted network-level coordination responsible high-level operations.

Language: Английский

Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review DOI Creative Commons
Valerio Manippa, Annalisa Palmisano, Michael A. Nitsche

et al.

Neuropsychology Review, Journal Year: 2023, Volume and Issue: 34(1), P. 338 - 361

Published: March 6, 2023

Abstract Despite the numerous pharmacological interventions targeting dementia, no disease-modifying therapy is available, and prognosis remains unfavorable. A promising perspective involves tackling high-frequency gamma-band (> 30 Hz) oscillations involved in hippocampal-mediated memory processes, which are impaired from early stages of typical Alzheimer’s Disease (AD). Particularly, positive effects entrainment on mouse models AD have prompted researchers to translate such findings into humans using transcranial alternating current stimulation (tACS), a methodology that allows endogenous cortical frequency-specific manner. This systematic review examines state-of-the-art use gamma-tACS Mild Cognitive Impairment (MCI) dementia patients shed light its feasibility, therapeutic impact, clinical effectiveness. search two databases yielded 499 records resulting 10 included studies total 273 patients. The results were arranged single-session multi-session protocols. Most demonstrated cognitive improvement following gamma-tACS, some showed neuropathological markers, suggesting feasibility these anyhow far strong evidence available for models. Nonetheless, small number their wide variability terms aims, parameters, measures, make it difficult draw firm conclusions. We discuss methodological limitations studies, proposing possible solutions future avenues improve research dementia.

Language: Английский

Citations

31
Multisensory flicker modulates widespread brain networks and reduces interictal epileptiform discharges DOI Creative Commons
Lou T. Blanpain, Eric R. Cole, Emily Chen

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 11, 2024

Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep structures and are practical for chronic daily home use desirable a variety of applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach modulates hippocampus in mice, but its effects humans poorly defined. We therefore quantified the neurophysiological flicker with high spatiotemporal resolution patients focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) cross-over design, subjects different frequencies stimulation same recording session effect exposure on local field potential (LFP) power interictal epileptiform discharges (IEDs) as primary secondary outcomes, respectively. Flicker focally modulated potentials expected canonical cortices also medial temporal lobe prefrontal cortex, likely via resonance stimulated long-range circuits. Moreover, decreased discharges, pathological biomarker degenerative diseases, most strongly regions where were flicker-modulated, especially visual cortex lobe. This met scientific goal now closed. Our findings reveal how multi-sensory may cortical to mitigate activity humans.

Language: Английский

Citations

14
An update on the use of gamma (multi)sensory stimulation for Alzheimer’s disease treatment DOI Creative Commons
Valerio Manippa, Annalisa Palmisano, Marco Filardi

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Dec. 15, 2022

Alzheimer's disease (AD) is characterized by reduced fast brain oscillations in the gamma band (γ, > 30 Hz). Several animal studies show that inducing through (multi)sensory stimulation at 40 Hz has potential to impact AD-related cognitive decline and neuropathological processes, including amyloid plaques deposition, neurofibrillary tangles formation, neuronal synaptic loss. Therefore Gamma Entrainment Using Sensory (GENUS) among most promising approaches for AD patients' treatment. This review summarizes evidence on GENUS effectiveness, from models patients. Despite application human its infancy, available findings suggest feasibility treatment of AD. We discuss such results light parameter improvement possible underlying mechanisms. finally emphasize need further research development as a disease-modifying non-pharmacological intervention.

Language: Английский

Citations

31
Audiovisual gamma stimulation for the treatment of neurodegeneration DOI Creative Commons
Cristina Blanco‐Duque, Diane Chan, Martin C. Kahn

et al.

Journal of Internal Medicine, Journal Year: 2023, Volume and Issue: 295(2), P. 146 - 170

Published: Dec. 19, 2023

Alzheimer's disease (AD) is the most common type of neurodegenerative and a health challenge with major social economic consequences. In this review, we discuss therapeutic potential gamma stimulation in treating AD delve into possible mechanisms responsible for its positive effects. Recent studies reveal that it feasible safe to induce 40 Hz brain activity patients through range multisensory noninvasive electrical or magnetic methods. Although research clinical these interventions still nascent stages, suggest can yield beneficial effects on function, pathology, cognitive function individuals AD. Specifically, involving light, auditory, vibrotactile stimulation, as well techniques such transcranial alternating current stimulation. The precise underpinning are not yet fully elucidated, but preclinical have provided relevant insights. We evidence related both neuronal nonneuronal may be involved, touching upon relevance interneurons, neuropeptides, specific synaptic translating widespread within brain. also explore roles microglia, astrocytes, vasculature mediating function. Lastly, examine upcoming trials contemplate future applications management disorders.

Language: Английский

Citations

21
Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues DOI Creative Commons
Michael D. Hadler, Henrik Alle,

Jörg R. P. Geiger

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(7), P. 586 - 601

Published: May 18, 2024

Alzheimer's disease (AD) and schizophrenia (SCZ) represent two major neuropathological conditions with a high burden. Despite their distinct etiologies, patients suffering from AD or SCZ share common burden of disrupted memory functions unattended by current therapies. Recent preclinical analyses highlight cell-type-specific contributions parvalbumin interneurons (PVIs), particularly the plasticity cellular excitability, towards intact neuronal network function (cell-to-network plasticity) performance. Here we argue that deficits PVI cell-to-network may underlie in SCZ, explore therapeutic avenues: targeting PVI-specific neuromodulation, including neuropeptides, recruitment synchrony gamma frequency range (40 Hz) external stimulation. We finally propose these approaches be merged under consideration recent insights into human brain physiology.

Language: Английский

Citations

5
Single-session gamma sensory stimulation entrains real-time electroencephalography but does not enhance perception, attention, short-term memory, or long-term memory DOI Creative Commons

Chi-Chen Wu,

Ting Yin Lin,

Yu‐Hui Lo

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Studies have shown that gamma (40 Hz) audiovisual stimulation can enhance oscillations and improve cognitive functioning in patients with Alzheimer's disease. However, despite promising long-term results, the efficacy of short-duration or single-session 40 Hz entrainment humans has been questioned by behavioral studies fail to find observable aftereffects, for two possible reasons: 1) lack validated entrainment, as most lacked concurrent electroencephalography (EEG) data verify neural did take place, 2) diverse tests, not test a wide range factors. This study aimed increase sensitivity detecting entrainment. We employed mid- post-stimulation EEG monitoring ensure worked, comprehensive battery probes perception, attention, working memory, memory. Participants received 30 min synchronized light sound stimulation, followed visual perceptual task, attentional network change detection memory picture EEG. observed robust during but no significant oscillation after improvements. Despite online sensory requires consistent exposure induce neurological changes. Future research should determine optimal duration frequency maximize its therapeutic potential.

Language: Английский

Citations

0
Unleashing the potential: 40 Hz multisensory stimulation therapy for cognitive impairment DOI Creative Commons

Xiao Chen,

Zhongyue Lv,

Guomin Xie

et al.

Journal of Central Nervous System Disease, Journal Year: 2025, Volume and Issue: 17

Published: March 1, 2025

Cognitive impairment encompasses a spectrum of disorders marked by acquired deficits in cognitive function, potentially leading to diminished daily functioning and work capacity, often accompanied psychiatric behavioral disturbances. Alzheimer's disease (AD) Post-stroke (PSCI) are significant causes decline. With the global population getting older, AD PSCI becoming major health concerns, underscoring critical necessity for successful treatment options. In recent years, various non-invasive biophysical stimulation techniques, including ultrasound, light, electric, magnetic stimulation, have been developed central nervous system diseases. Preliminary clinical studies demonstrated feasibility safety these techniques. This review discuss impact 40 Hz multisensory on cerebral outcomes, progression both animal models individuals exhibiting deficits, such as PSCI. Furthermore, it summarizes potential neural pathways involved this therapeutic modality synthesizing evidence from variety within field. Subsequently, evaluates existing constraints technique underscores advantages therapy with goal enhancing management care

Language: Английский

Citations

0
Brainwaves and their entrainment influence the processing speeds of in-congruent stimuli DOI
Richa Phogat, Sandhya Basu, Aarsh Chotalia

et al.

Chaos Solitons & Fractals, Journal Year: 2025, Volume and Issue: 196, P. 116410 - 116410

Published: April 10, 2025

Language: Английский

Citations

0
Gamma oscillation modulation for cognitive impairment: A systematic review DOI Creative Commons
Emanuela Bartolini, Adolfo Di Crosta, Pasquale La Malva

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Background Gamma oscillation modulation has emerged as a potential non-invasive treatment to counteract cognitive impairment in Alzheimer's disease (AD) and mild (MCI). Non-invasive brain stimulation techniques like transcranial alternating current (tACS), gamma sensory (GSS), magnetic (TMS) show promise supporting specific functions. Objective To review evaluate the efficacy of benefiting functions among individuals with AD MCI. Methods A systematic was conducted, analyzing studies from 2015 2023 across databases such PubMed, Web Science, Scopus. Inclusion criteria focused on involving tACS, GSS, or TMS applied older adults MCI AD. total 438 articles were screened, which 10 met eligibility criteria. Results Findings suggest that especially targeting precuneus dorsolateral prefrontal cortex, benefits episodic memory performance. GSS also showed attention, while exhibited inconsistent but promising results when angular gyrus. However, heterogeneity study designs small sample sizes limit generalizability these outcomes. Conclusions offers for patients MCI, particularly support. Further larger samples well-designed protocols are needed confirm its therapeutic optimize intervention parameters.

Language: Английский

Citations

0
Promising neurostimulation routes for targeting the hippocampus to improve episodic memory: A review DOI Creative Commons

Elva Arulchelvan,

Sven Vanneste

Brain Research, Journal Year: 2023, Volume and Issue: 1815, P. 148457 - 148457

Published: June 12, 2023

This review aims to highlight modern neurostimulation approaches that are effectively activating the hippocampus and enhancing episodic memory performance. The is a brain region known play an essential role in processes. However, as it nestled deep within brain, has been challenging target for traditional approaches, with studies reporting inconsistent effects. Recent suggest more than half of electrical current from non-invasive transcranial stimulation (tES) methods may be attenuated by human scalp, skull, cerebral spinal fluid. Thus, this novel showing promise alternative routes hippocampal circuitry. Early evidence suggests temporal interference, closed-loop individualized protocols, sensory peripheral nerve-targeted tES protocols warrant further investigation. These each provide promising a) increasing its functional connectiveness key regions, b) strengthening synaptic plasticity mechanisms, or c) neural entrainment specifically between theta gamma frequencies these regions. Importantly, three mechanisms hippocampus' structural integrity negatively impacted throughout progression Alzheimer's Disease, deficits likewise evident early stages. Consequently, depending on validation reviewed here, techniques could offer significant applied therapeutic value patients suffering neurodegenerative diseases including amnestic Mild Cognitive Impairment disease.

Language: Английский

Citations

9