EXPERIMENTAL ANIMALS, Journal Year: 2023, Volume and Issue: 72(3), P. 285 - 293
Published: Jan. 1, 2023
Alzheimer's disease (AD), a progressive neurodegenerative characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among elderly. Amyloid aggregation, tau hyperphosphorylation, neural cell loss are main pathological features. Various hypotheses have been proposed to explain development AD. Some therapeutic agents shown clinical benefits in patients with AD; however, many these failed. The degree associated severity Adult neurogenesis, which governs emotional behaviors, occurs hippocampus, some research groups reported that transplantation into hippocampus improves AD model mice. Based on findings, stem therapy for has recently attracted attention. This review provides past present strategies management treatment
Language: Английский
Citations
4Comprehensive Review on the Virulence Factors and Therapeutic Strategies with the Aid of Artificial Intelligence against Mucormycosis
ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(5), P. 1431 - 1457
Published: April 29, 2024
Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19 pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to excessive steroid and antibiotic use, poor hospital hygiene, crowded settings. Major contributing factors include diabetes weakened immune systems. main manifesting forms of CAM─cutaneous, pulmonary, deadliest, rhinocerebral─and disseminated infections elevated mortality rates 85%. Recent focus lies on small-molecule inhibitors due their advantages over standard treatments like surgery liposomal amphotericin B (which carry several long-term adverse effects), offering potential central nervous system penetration, diverse targets, simpler dosing owing small size, rendering ability traverse blood–brain barrier via passive diffusion facilitated by phospholipid membrane. Adaptation versatility mucormycosis are multitude virulence factors, enabling pathogen dynamically respond various environmental stressors. A comprehensive understanding these mechanisms imperative for devising effective therapeutic interventions against this highly opportunistic that thrives immunocompromised individuals through its angio-invasive nature. Hence, Review delineates principal it employs persist challenging host environments, current progress developing them.
Language: Английский
Citations
1Emerging paradigms in Alzheimer's therapy
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 981, P. 176872 - 176872
Published: Aug. 6, 2024
Language: Английский
Citations
1Structure-based computer-aided drug design to identify potential lead molecules for Asparaginyl Endopeptidase inhibitors
Journal of Biomolecular Structure and Dynamics, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19
Published: Oct. 15, 2024
The enzyme Asparaginyl Endopeptidase (AEP) is associated with proteinopathy-related pathologies such as Alzheimer's disease (AD) and Frontal Temporal Dementia (FTD). onset of by AEP due to cleaved fragments forming protein aggregates resulting in neurodegeneration. Unfortunately, there are no clinically approved small molecule inhibitors for AEP, therefore, it serves an unmet medical need the design development potential novel molecules. In developing proteolytic activity, a structured approach utilizing structure-based computer-aided drug (SB-CADD) parameters was employed. This involved virtual high throughput screening (vHTS) across various CNS-focused databases enriched diverse functionality. We identified top sixty ligands based on glide XP-docking score out 10 million ligands. free binding energy then calculated using MM-GBSA all selected molecules which resulted discovering that AEPI-1 AEPI-6 (Asparaginyl inhibitors) displayed affinity towards catalytic triad. Further investigation determined six hits form stable complexes during 50 ns molecular dynamic simulations. also observed AEPI-2 demonstrated highest stability within pockets. Post-MD analyses DCCM, PCA, PDF, ADMET properties were evaluated. By bridging observations, we these occupy active site β-helix (β1, β3, β4) S1 pocket additional sites α1 β5, suggesting its suitability candidate discovery against Endopeptidase.
Language: Английский
Citations
1Recent advances and future therapy development for Alzheimer’s disease and related disorders
Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(9), P. 1877 - 1878
Published: Dec. 21, 2023
Department of Neurology, David Geffen School Medicine, University California Los Angeles, CA, USA (Hong M, Bitan G) Chemistry and Biochemistry, M) Molecular Biology Institute, Brain Research California, (Bitan *Correspondence to: Gal Bitan, PhD, [email protected]. This is an open-access article distributed under the terms Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, reproduction in any medium, provided original work properly cited.
Language: Английский
Citations
3Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(39), P. 9404 - 9418
Published: Jan. 1, 2023
Alzheimer's disease (AD) is the most common neurodegenerative among elderly, and morbidity increases with aging population aggravation. The clinical symptoms of AD mainly include cognitive impairment memory loss, which undoubtedly bring a huge burden to families society. Currently, drugs in use only improve but do not cure or prevent progression disease. Therefore, it urgent for us develop novel therapeutic strategies effective treatment. To provide better theoretical basis exploring future treatment, this review introduces recent treatment technologies from three aspects, including nanoparticle (NP) based drug therapy, biological therapy physical therapy. nanoparticle-mediated approaches at nanomaterial-neural interface system are described detail, particular magneto-regulated by magnetic field actuating nanoparticles highlighted. Promising application magneto-mechanical force regulated strategy also addressed, offer possibilities remote manipulation precise manner. In future, may be possible physicians realize remote, using technology on combination an external field.
Language: Английский
Citations
2Research Progress of Chemical Synthesis Drugs and Biotechnology Drugs for Alzheimer’s Disease
Open Journal of Natural Science, Journal Year: 2024, Volume and Issue: 12(02), P. 440 - 448
Published: Jan. 1, 2024
Language: Английский
Citations
0Peptidomimetics design and characterization: Bridging experimental and computer-based approaches
Progress in molecular biology and translational science, Journal Year: 2024, Volume and Issue: unknown, P. 279 - 327
Published: July 25, 2024
Language: Английский
Citations
0Structure‐Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid‐β Aggregation
Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(58)
Published: Aug. 7, 2024
Abstract Amyloid‐beta aggregation is considered one of the factors influencing onset Alzheimer's disease. Early prevention such should alleviate disease condition by applying small molecule compounds that shift equilibrium toward soluble form peptide or slow down process. We have discovered fluorinated benzenesulfonamides particular structure slowed amyloid‐beta process more than three‐fold. synthesized a series ortho‐para and meta‐para double‐substituted inhibited to variable extent yielding detailed picture structure‐activity relationship. Analysis compound chemical effect on in artificial cerebrospinal fluid showed necessity arrange benzenesulfonamide, hydrophobic substituent, benzoic acid way. The amyloid beta aggregate fibril structures varied cross‐sectional height depending applied inhibitor indicating formation complex with compound. Application selected inhibitors increased survivability cells affected peptide. Such may be developed as drugs against
Language: Английский
Citations
0Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease
Advances in Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 13(03), P. 65 - 94
Published: Jan. 1, 2024
Language: Английский
Citations
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