Journal of Clinical Anesthesia, Journal Year: 2024, Volume and Issue: 94, P. 111399 - 111399
Published: Jan. 20, 2024
Language: Английский
BMC Musculoskeletal Disorders, Journal Year: 2024, Volume and Issue: 25(1)
Published: Jan. 17, 2024
Postoperative delirium is a common problem affecting admitted patients that decreases patient satisfaction and increases the cost complexity of care. The purpose this study was to use American College Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database compare rates risk factors postoperative for total hip arthroplasty (THA) hemiarthroplasty indicated osteoarthritis or proximal femur fracture.
Language: Английский
Citations
9
Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11
Published: March 13, 2023
Hip fracture is the most devastating type of osteoporosis-related fracture, and a major worldwide public health problem with high socioeconomic burden, morbidity rate, mortality rate. Thus, it crucial to uncover risk factors protective create hip prevention strategy. In addition briefly review some well accepted this mainly summarized recent advances in identification emerging or for terms regional differences medical services, diseases, drugs, mechanical load, neuromuscular mass, genes, blood types, cultural differences. This provides comprehensive associated effective measures discusses issues that need further investigation. These include determination influencing mechanism triggering their interlinked correlation other factors, as confirmation correction particularly those are still controversial. findings will aid optimizing strategy preventing fracture.
Language: Английский
Citations
11
BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 13, 2024
Postoperative delirium (POD) is the most common complication following surgery in elderly patients. During pharmacist-led medication reconciliation (PhMR), a predictive risk score considering risk-increasing drugs and other available factors could help to identify
Language: Английский
Citations
4
Revista Española de Geriatría y Gerontología, Journal Year: 2025, Volume and Issue: 60(1), P. 101571 - 101571
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 6, 2025
Various factors contribute to postoperative delirium (POD) in elderly patients undergoing hip fracture surgeries. Sarcopenia was defined as the progressive loss of skeletal muscle mass and strength associated with aging. The aim this study explore prevalence POD sarcopenia geriatric surgeries investigate correlation between preoperative POD. After applying specific inclusion exclusion criteria, information 234 were retrospectively collected. screened for 4A's Test diagnosed DSM-5 criteria. incidences calculated. demographic perioperative features well comorbidities delirious non-delirious analyzed risk analysis conducted through univariate multivariate regression analysis. 48.7% POD, 78.95% which females. average age 84.75 years 80.63 years, respectively. incidence 41.02% all included 60.53% 20.55% patients. Results showed that (OR:5.281, 95%CI 2.988-9.337, p = 0.000), increase per year (OR:1.128, 95CI 1.070-1.190, operation duration (OR:1.017, 1.004-1.030, 0.011), intertrochanteric (OR:2.571, 1.517-4.358, dementia (OR: 6.029, 2.532-14.359, ASA > 2 6.955, 3.461-13.976, coronary heart disease 2.201, 1.257-3.854, 0.006), renal insufficiency 2.215, 1.187-4.133, 0.012) COPD 2.554, 1.414-4.615, 0.002) identified 2.457, 95% CI 1.226-4.923, 3.968, 1.805-8.722, 0.001), 3.912, 1.390-11.014, 0.010) 2.176, 1.044-4.538, 0.038) independent are high. is an factor
Language: Английский
Citations
0
Journal of Orthopaedic Surgery and Research, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 22, 2025
Postoperative metabolic disorders and inflammatory responses are closely associated with postoperative delirium (POD). Preoperative oral carbohydrate intake can alleviate insulin resistance the response. This study aimed to evaluate effects of preoperative on incidence POD in older patients undergoing lower limb orthopedic surgery. Eighty were randomly assigned 200 mL solution (Group CHO) 2 h before surgery or fasting for 8 C). The primary outcome was POD. Fasting plasma glucose, interleukin (IL)-6, C-reactive protein (CRP) levels assessed 1, 3, 5 days after (D1, D3, D5). Group CHO than that C (P = 0.005). Blood IL-6 CRP significantly those D1 D3 < 0.05). reduce by ameliorating reducing responses. ChiCTR2300070154, Date registration: 03/04/2023.
Language: Английский
Citations
0
Journal of Orthopaedics and Traumatology, Journal Year: 2025, Volume and Issue: 26(1)
Published: Feb. 28, 2025
Abstract Background This retrospective analysis was performed to investigate the potential influence of intra-operative blood transfusion (IBT) in patients aged 65 years or older with intertrochanteric fractures (IF) who underwent intramedullary fixation. Methods The outcomes interest included incidence postoperative delirium (POD), pain score at discharge, length hospital stay (LOS), functional outcomes, and mortality. study all surgically treated IF between Jan. 2018 Dec. 2021. Data on patient demographics, injury-related factors, surgical procedures, intraoperative details, in-hospital information, were collected. In order mitigate confounding selection bias, researchers employed propensity matching (PSM) technique using a 1:1 ratio via caliper method. Following PSM, association IBT outcome analyses assessed McNemar's Chi-square tests. Additionally, Spearman correlations IBT, POD computed. Results Out initial 2159 consecutive screened, final sample 1681 individuals included, consisting 1278 non-IBT group 403 group. After each comprised 298 participants. disparities rate became significant after employing score-based ( P < 0.001 0.029, respectively), despite their lack significance prior matching. There no notable distinctions observed other operation-related data, LOS, crude mortality rates 30-day, 90-day, 12-month intervals before PSM. Furthermore, = 0.006) 0.013) significantly associated IBT. Conclusion conclusion, increases hinders recovery elderly hip fracture.
Language: Английский
Citations
0
Journal of the American Medical Directors Association, Journal Year: 2025, Volume and Issue: 26(5), P. 105537 - 105537
Published: March 22, 2025
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(10), P. e41569 - e41569
Published: March 7, 2025
Preoperative delirium is common and associated with poor clinical outcomes in elderly hip fracture patients. Although inflammatory markers have shown potential predicting postoperative delirium, their relevance to preoperative remains unclear. This study aimed investigate the relationship between improve risk prediction management strategies. We retrospectively studied 548 patients aged 70 years or older. The primary outcome was diagnosed using Confusion Assessment Method (CAM). Explanatory variables included (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte [PLR], systemic immune-inflammation index [SII], burden [IBI], inflammation response [SIRI]). About 7.66% of developed study. These were more likely be older, comorbid cardiovascular disease, transferred an internal medicine ward for further treatment (P < .001). Multivariate analysis revealed that older age (OR = 1.11, 95% CI 1.04-1.18) disease 2.94, 1.51-5.67) independently occurrence delirium. No significant differences observed groups markers: NLR .70), PLR .09), IBI SII .21), SIRI .80). Older comorbidities independent factors associations found markers. Future research should explore additional biomarkers refine stratification this population.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320719 - e0320719
Published: March 27, 2025
Background Postoperative delirium (POD) is one of the most common complications in geriatric patients following surgery. Physiological concentration bilirubin possesses anti-inflammatory, antioxidant and neuroprotective effects, which are important protective mechanisms against POD. This study aimed to explore relationship between preoperative serum POD undergoing joint replacement. Methods Geriatric who underwent hip or knee replacement surgery under intrathecal anesthesia were included. These had American Society Anesthesiologists (ASA) grades I III. The with a history psychiatric neurological disorders, infectious diseases sepsis, hemolytic anemia, liver diseases, performed general combined anesthesia, insufficient surgical information excluded. Patients’ age, gender, weight, height, ASA classification, function within week before surgery, Mini–Mental State Examination (MMSE) scores, type, dosage medications, intraoperative bleeding volume, postoperative average numeric rating scale (NRS) pain occurrence Delirium Rating Scale–Revised–98 (DRS–R–98) scores for collected. Results A total 269 eligible inclusion study, 23.05% (62/207) exhibiting Patients exhibited higher age lower (TBIL) indirect (IBIL) MMSE (all p < 0.05). Univariate logistic regression analysis showed that above variables correlated Multivariate revealed was risk factor ( 0.001, OR = 1.14, 95% CI [1.07 – 1.21]), while weight 0.041, 0.96, [0.92 0.99]), IBIL levels 0.012, 0.65, [0.47–0.91]) 0.84, [0.78 0.91]) served as factors receiver operating characteristic (ROC) curve analysis. estimated cutoff value predicting 6.65 μmol/L, area (AUC) 0.63. below μmol/L incidence Conclusion Low predictor
Language: Английский
Citations
0