Clinical Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 11, P. 100284 - 100284
Published: Jan. 1, 2024
Dual-task (DT) performance is impaired in Parkinson's disease (PD), contributing to bradykinesia, postural instability, freezing of gait, and falls. Tactile cueing, including vibrotactile stimulation, has been suggested improve DT PD.
Language: Английский
Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 85, P. 101837 - 101837
Published: Jan. 9, 2023
Language: Английский
Citations
17
EClinicalMedicine, Journal Year: 2023, Volume and Issue: 66, P. 102338 - 102338
Published: Dec. 1, 2023
Parkinson's disease is a progressive neurological with limited treatment options. Animal models and proof-of-concept case series have suggested that photobiomodulation may be an effective adjunct for the symptoms of disease. The aim was to determine safety feasibility transcranial (tPBM) reduce motor signs disease.In this double-blind, randomised, sham-controlled trial, patients (aged 59-85 years) idiopathic were treated tPBM helmet 12 weeks (72 treatments either active or sham therapy; stage 1). Treatment delivered in participants' homes, monitored by internet video conferencing (Zoom). Stage 1 followed no those on therapy (active-to-no-treatment group), (sham-to-active participants who chose continue (stage 2). device red infrared light head 24 min, 6 days per week. primary endpoints signs, as assessed modified Movement Disorders Society revision Unified Disease Rating Scale Part III (MDS-UPDRS-III)-motor scale. This trial registered ANZCTR, ACTRN 12621001722886.Between Dec 6, 2021, Aug 12, 2022, 20 randomly allocated each two groups (10 females plus 10 males group). All group 18 completed treatment. 14 full well tolerated feasible deliver, only minor, temporary adverse events. Of nine suspected events identified, minor reactions been attributable sham-to-active during trial. One participant experienced leg weakness. A second reported decreased fine function right hand. Both continued mean MDS-UPDRS-III scores at baseline, after treatment, 26.8 (sd 14.6), 20.4 12.8), 12.2 8.9), respectively, active-to-no-treatment these values 21.3 9.4), 16.5 15.3 10.8), respectively. There significant difference between any assessment point. baseline 5.5 (95% confidence interval (CI) -2.4 13.4), 3.9 CI -3.5 11.3 2 -3.1 2.7 -10.6).Our findings add evidence base suggest safe, tolerable, non-pharmaceutical While future work needed our results lay foundations adequately powered randomised placebo-controlled clinical trial.SYMBYX Pty Ltd.
Language: Английский
Citations
9
Life, Journal Year: 2022, Volume and Issue: 13(1), P. 78 - 78
Published: Dec. 27, 2022
Parkinsonian tremors are sometimes confused with essential or other conditions. Recently, researchers conducted several studies on tremor evaluation using wearable sensors and devices, which may support accurate diagnosis. Mechanical devices also commonly used to treat have been actively researched developed. Here, we aimed review recent progress the efficacy of related tremors.The PubMed Scopus databases were searched for articles. We "Parkinson disease" "tremor" "device".Eighty-six articles selected by our systematic approach. Many demonstrated that diagnosis in patients PD can be done accurately machine learning algorithms. suppression include deep brain stimulation (DBS), electrical muscle stimulation, orthosis. In years, adaptive DBS optimization parameters studied further improve treatment efficacy.Due developments state-of-the-art techniques, effectiveness diagnosing evaluating suppressing it these is satisfactorily high many studies. However, than DBS, no practical use. To acquire high-level evidence, large-scale randomized controlled trials needed devices.
Language: Английский
Citations
14
BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 9, 2024
Parkinson's disease is a progressive neurodegenerative characterized by clinical motor signs and non-motor symptoms that severely impact quality of life. There an urgent need for therapies might slow, halt or even reverse the progression existing delay onset new symptoms. Photobiomodulation therapy has shown potential to alleviate some in animal studies small trials.
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: July 7, 2023
Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry neurodegenerative This study aimed to evaluate the of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images 36 each idiopathic (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those IDYS had a significantly higher occipital index (OI) than those CSDH (p = 0.014). When cephalic (CI) was divided into normal abnormal groups, there significant difference between 0.000, α 0.017) PD 0.031, 0.033). The age onset correlated CI (τ - 0.282, p 0.016). Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed correlation OI 0.372, 0.002). different from that CSDH. There CI, as well BFMDRS-M OI, suggesting short heads growth phase balance might be related genesis its effect on symptoms.
Language: Английский
Citations
2
Sao Paulo Medical Journal, Journal Year: 2024, Volume and Issue: 142(5)
Published: Jan. 1, 2024
BACKGROUND: For more than 30 years, deep brain stimulation (DBS) has been a therapeutic tool for Parkinson's disease (PD) treatment. DBS can ameliorate several motor and non-motor symptoms improve the patients' quality of life. OBJECTIVES: To analyze global scientific production original review articles on treatment using stimulation. DESIGN AND SETTING: Descriptive, bibliometric study with quantitative approach. METHOD: The research protocol was conducted in March 2023 Web Science database. Six hundred eighty-four were included analysis. Data imported into RStudio Desktop Software, linked to R Software. Bibliometrix package, its Biblioshiny web interface, VOSviewer software used RESULTS: international began 1998. Movement Disorders is journal largest number published most cited. Michael Okun Andres Lozano are authors who produced this area. University Florida active affiliated institution Brazil. United States collaborations mainly by local researchers. In contrast, countries such as Kingdom Canada have high multi-country publications. 15 cited studies predominantly investigated subthalamic nucleus CONCLUSION: relatively novel approach, that expanded over last twenty-five years. Most restricted specialized journals. States, Europe, China held articles.
Language: Английский
Citations
0
npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)
Published: Sept. 30, 2024
Language: Английский
Citations
0
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 11, 2024
SCIENTIFIC ABSTRACT Introduction Current treatments for patients with Parkinson’s disease (PwP) can fail to address gait disturbance and falls, which in turn affect quality of life (QoL). The CUE1 device delivers cueing vibrotactile stimulation showing potential alleviate motor symptoms reduce falls based on preliminary user testing results. Objectives To evaluate the feasibility, safety, tolerability its effect non-motor PwP. Methods PwP used 9-weeks were assessed at week 0, 3, 6, 9 MDS-UPDRS Part-III, Timed Up Go (TUG), TUG dual task (DT), Functional Gait Assessment (FGA), Bradykinesia Akinesia Incoordination (BRAIN) test. Patients reported outcomes through Part-I, -II, -IV Pittsburgh Sleep Quality Index (PSQI). Results Ten (5 females, age range: 46-80; duration: 3-9 years) completed intervention 100% compliance no adverse events. comfort usability rated highly (80%). Immediate was observed MDS-UPDRS- III(45.40±12.22 vs 39.60±11.74, p=0.008), TUG(11.53±1.92 11.08±1.94, p=0.022), DT(18.57±5.75 17.61±6.28, p=0.037) FGA(16.40±3.86 18.60±3.92, p=0.007). Cumulative noted MDS-UPDRS-III(45.40±12.22 27.80±12.32, p=0.005), FGA(18.60±3.92 23.10± 2.85, p<0.001), 13.58±7.05, p=0.031), BRAIN kinesia (45.10±14.39 42.10±12.74, p<0.001) incoordination (24331.09±38017.46 14059.91± 9030.96, p=0.016) scores, PSQI(10.10±4.95 6.90±3.81, p=0.002), MDS-UPDRS-I(18.60±6.75 12.20±3.68, p=0.011), II(17.30±7.29 11.90±8.67, MDS-UPDRS-IV(7.50±3.75 3.40±2.95, p=0.003). Conclusion In this unblinded, feasibility study, appeared be a feasible safe improving features. PLAIN Background This study looked use called CUE1, provides rhythmic pulsing vibration help movement non-movement people (PwP). Even current treatments, issues walking falling still many patients. goal see if could helpful, safe, easy-to-use tool symptoms, like risk falling, as well sleep. Procedures women, aged 46-80) who had years weeks. Everyone finished using regularly negative side effects. 80% ease use. Significant improvements seen abilities (using MDS-UPDRS-III test), speed, fall risk. Over weeks, participants showed further progress movement, balance, coordination. Non-movement sleep, also improved. Conclusions device, gentle vibrations assist found easy use, effective. It improved both movement-related balance walking, makes it promising new treatment option Parkinson’s.
Language: Английский
Citations
0
Frontiers in Digital Health, Journal Year: 2024, Volume and Issue: 6
Published: Nov. 13, 2024
Objective Several systematic reviews have shown that physical exercise positively affects motor function (MF) and quality of life (QoL) in patients with Parkinson's disease (PD). After the coronavirus (COVID-19) pandemic, numerous studies were conducted to reveal effects telerehabilitation for PD. However, only a few empirical results online programs PD been reported. Therefore, this study aimed determine an cognitive training program on MF QoL Methods We evaluated impact our by comparing data at baseline after six months intervention. For assessment, we used Schwab England Activities Daily Living scale Disease Questionnaire (PDQ-39), whereas, MF, measured movement status using modified 20-m walk test timed up-and-go (TUG) test. Results enrolled 20 19 study. PDQ-39, social support ( p = 0.046, δ 0.320) cognitions 0.028, 0.268) significantly improved. Additionally, cadence 0.032, g −0.377) exam duration 0.003, 0.296) forward gait 0.341) TUG showed significant differences before Conclusion Our suggest affect individuals
Language: Английский
Citations
0
Clinical Parkinsonism & Related Disorders, Journal Year: 2024, Volume and Issue: 11, P. 100284 - 100284
Published: Jan. 1, 2024
Dual-task (DT) performance is impaired in Parkinson's disease (PD), contributing to bradykinesia, postural instability, freezing of gait, and falls. Tactile cueing, including vibrotactile stimulation, has been suggested improve DT PD.
Language: Английский
Citations
0