Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Sept. 20, 2022

Background: Inflammation promotes the progression of Alzheimer's disease (AD). In this study, we explored effect dexmedetomidine on inflammation and cognitive function in a mouse model AD. Methods: 5xFAD mice were intragastrically administered saline, dexmedetomidine, or yohimbine for 14 days. The effects acquisition retention memory Morris water-maze test Y maze evaluated. deposition amyloid beta protein (Abeta) cytokine levels hippocampus assessed. expression Bace1 NFκB-p65 was assessed by Western blotting. Results: Compared with WT mice, exhibited impairment water test. Cognitive decline alleviated reversed α2 adrenoceptor antagonist yohimbine. saline treatment, led to reduction Abeta area (p < 0.05) mean gray value 0.01) mice. inhibited activation astrocytes microglia hippocampal DG reduced GFAP IBA1 0.01). level IL-1β decreased significantly after treatment compared Yohimbine neutralized dexmedetomidine. Dexmedetomidine BACE1 NF-κB p65 0.01), these changes treatment. Conclusion: alleviates decline, inhibits neuroinflammation, prevents is mediated adrenoceptor-mediated anti-inflammatory pathway. may be effective AD better choice sedation

Language: Английский

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Transcriptomic Signatures of Neuronally Derived Extracellular Vesicles Reveal the Presence of Olfactory Receptors in Clinical Samples from Traumatic Brain Injury Patients

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2777 - 2777

Published: Feb. 28, 2024

Traumatic brain injury (TBI) is defined as an to the by external forces which can lead cellular damage and disruption of normal central nervous system functions. The recently approved blood-based biomarkers GFAP UCH-L1 only detect injuries are detectable on CT, not sensitive enough diagnose milder or concussion. Exosomes small microvesicles released from cell a part extracellular communication in well diseased states. objective this study was identify messenger RNA content exosomes injured neurons new potential for TBI. Human severe traumatic samples were used study. isolated neuronal total transcriptomic sequencing performed. data serum showed mRNA transcripts several genes. In particular, mRNAs olfactory receptor genes present at elevated concentrations exosomes. Some these OR10A6, OR14A2, OR6F1, OR1B1, OR1L1. CSF similar elevation receptors. We further validated expression mild TBI patients, up-regulation receptors observed. experiments suggest that neuroepithelium following may cause release Hence, be explored diagnosis

Language: Английский

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Complement Proteins in Serum Astrocyte-Derived Exosomes Are Associated with Poststroke Cognitive Impairment in Type 2 Diabetes Mellitus Patients

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 99(1), P. 291 - 305

Published: April 23, 2024

The complement system plays crucial roles in cognitive impairment and acute ischemic stroke (AIS). High levels of proteins plasma astrocyte-derived exosomes (ADEs) were proven to be associated with Alzheimer's disease. We aimed investigate the relationship serum ADEs poststroke type 2 diabetes mellitus (T2DM) patients.

Language: Английский

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Research Progress of Neurogenic Exosomes in the Treatment of Alzheimer’s Disease

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(09), P. 1034 - 1041

Published: Jan. 1, 2024

Language: Английский

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Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death

NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)

Published: Dec. 8, 2024

Language: Английский

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