Can walking capacity predict respiratory functions of people with Parkinson’s disease?

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Introduction People with Parkinson’s Disease (PwPD) and an impaired respiratory profile show a lower walking ability. Still, it is unknown if there relationship between ability function that can be used to predict the latter. This cross-sectional study evaluated in PwPD. Methods Seventeen older PwPD, 60 80 years old were asked perform 10-m test at self-selected, fast speed, tests these variables analyzed by multiple linear regression. Results The revealed 44% of patients restrictive, 33% obstructive, 22% mixed. 73% PwPD presented low lung capacity, as demonstrated forced expiratory volume 1 s divided vital capacity (FEV1/FVC). Multiple regression self-selected speed explained 53 58% ( p = 0.027 0.016) variation maximal inspiratory pressures, respectively. 62 66% 0.008 0.005) pressure variation, Furthermore, locomotor rehabilitation index 39% 0.022) variance FEV1/FVC. Conclusion These results suggest ability, particularly speeds, suitable screening parameter for pulmonary impairments indicates expire rapidly proportion Thus, easily applicable low-cost biomarker assessing changes

Language: Английский

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Prospective Dysphagia Assessment in Adult Patients With Nephropathic Cystinosis

Muscle & Nerve, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Myopathy and dysphagia are common manifestations of nephropathic cystinosis, a rare autosomal recessive lysosomal storage disorder. We previously demonstrated that both the oral pharyngeal phases swallowing affected impact function quality life in patients. To better understand characterize impairment, we evaluated patients with cystinosis experiencing myopathy. prospectively who had participated prior clinical trial readiness study myopathy dysphagia, using functional outcomes video fluoroscopic studies. Eight underwent assessments. Oral stages were all subjects. There was an improvement stage (Visit 3 8 [3:9]; Visit 4 5 [1:5]) between Visits median 1090 days (IQR [921:1288]) while Modified Barium Swallow Impairment Profile scores stayed unchanged same amount time. also M. D. Anderson Dysphagia Inventory (MDADI) (MDADI-C 73 [62:87], 96 [76:99]; MDADI-F 18 [17:21], 25 [23:25]), indicating higher pertaining to swallowing. Despite progressive nature myopathic changes typically described some metrics. This may suggest possible late-onset effect respiratory training or cognitive-behavioral from repeated measurements.

Language: Английский

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Effects of an incentive spirometer versus a threshold inspiratory muscle trainer on lung functions in Parkinson’s disease patients: a randomized trial

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 13, 2023

Abstract Upper airway obstruction, reduced maximal expiratory and inspiratory flows, lung volumes, abnormal ventilatory control, diaphragmatic dyskinesias are reported in patients with Parkinson’s disease (PD). Inspiratory muscle training (IMT) has been to be effective improving respiratory functions; however, no studies have compared the effects of incentive spirometer (IS) threshold trainer (TIMT) PD. The study aimed compare IS TIMT on maximum pressure (MIP), 6-min walk distance (6-MWD), forced vital capacity (FVC), volume 1 s (FEV1), peak flow rate (PEFR) stage 1–3 according Hoehn Yahr scale. 18 were randomly assigned two groups, i.e., group. group received IMT volume-based IS, TIMT. MIP, 6-MWD, FVC, FEV1, PEFR measured before after six weeks training. In group: A significant increase ( p < 0.05) was observed MIP 6-MWD by 18.13 5%, respectively. 30.15 8.94%, Both groups difference > PEFR. When compared, a greater or for effectively increased (Hoehn scale) No improvement any techniques. is more than 6-MWD.

Language: Английский

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Short-term effects of "Yijinjing Wohu Pushi" posture-voice therapy on speech in Parkinson's disease after STN-DBS

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 27, 2024

Abstract Hypokinetic dysarthria in Parkinson's Disease (HD-PD) deteriorates patients' quality of life by impeding communication and social engagement. Existing treatments like levodopa drugs deep brain stimulation (DBS) can improve motor symptoms but fall short addressing speech-related impairments; effective speech therapies tend not to mandate the posture, which potentially hinders vocal performance. Here we first proposed a therapeutic protocol that specified lunging-and-clawing posture (Wohu Pushi method from Yijinjing) during vocalization training. The aimed ensure PD patients could accomplish training even with moderate impairments. A total 20 HD-PD implanted stimulators subthalamic nuclei (STN-DBS) participated one session training, either following our posture-voice therapy (PVT) or conventional voice (CVT). Results indicated maximum phonation time was significantly elongated PVT(3.85±2.81s) CVT(0.46±2.24s), formant-distance increased PVT(95.80±112.71Hz) compare CVT(-47.10±84.28Hz). Our results demanding appropriate amount postural maintenance vocalization, it might facilitate recovery functions. This study warranted larger-scale clinical trials understand impact, limitation, optimization for HD-PD.

Language: Английский

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Effects of multicomponent combinations training on respiratory function in individuals with Parkinson’s Disease: a randomized clinical trial

Journal of Bodywork and Movement Therapies, Journal Year: 2024, Volume and Issue: 42, P. 15 - 22

Published: Nov. 28, 2024

Language: Английский

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ASPECTS OF A HOLISTIC APPROACH IN THE TREATMENT OF PATIENTS WITH PARKINSON'S DISEASE

Bulletin of Problems Biology and Medicine, Journal Year: 2024, Volume and Issue: 1(4), P. 12 - 12

Published: Jan. 1, 2024

Language: Английский

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Feasibility and Satisfaction of a Smartphone Application-based Voice and Speech Training Program for Parkinson’s Disease: A Preliminary Rater-blinded Single Arm Pretest-Posttest Study (Preprint)

Journal of Medical Internet Research, Journal Year: 2024, Volume and Issue: 27, P. e63166 - e63166

Published: Dec. 30, 2024

Background Up to 75% of patients with Parkinson disease (PD) experience voice and speech impairments, such as breathy phonation low volume, which worsen over time negatively impact the quality life. However, given their increasingly limited mobility, face-to-face therapy is often inaccessible. Mobile health (mHealth) apps offer accessible cost-effective alternatives; yet, application in PD-specific, self-delivered remains underexplored. Objective This study aimed evaluate feasibility, adherence, satisfaction a smartphone app for PD, designed minimize speech-language pathologist involvement while promoting patient independence. In addition, it seeks assess preliminary therapeutic effectiveness addressing problems this population. Methods A single-arm, rater-blinded, pretest posttest was conducted between September November 2023. Patients PD who have no problem using Android (Google) smartphones were recruited. Participants downloaded researcher-developed mHealth on participated patient-tailored 5-week home-based training program. Each session included 5 stages: breathing, oral motor exercises, loudness, prosody, functional speaking. The program consisted 20 sessions, participants completing 1 per day, 4 days week. lasted approximately 20-30 minutes. Adherence monitored through logs, assessed phone survey, evaluated acoustic analysis auditory-perceptual assessments. Results Out 30 initially recruited, but 2 them withdrew. 25 completed all sessions 3 dropped out. adherence above 90% (80%, 20/25), 70% (16%, 4/25), below 4/25). Satisfaction (18/24) among 24 people survey. Significant improvements observed measures: maximum increased from 11.15 (SD 5.38) seconds 14.01 5.64) (P=.003), vocal intensity 71.59 4.39) dB 73.81 3.48) (P<.001) across both sustained reading tasks. Voice scores GRBAS (grade, roughness, breathiness, asthenia, strain) scale improved significantly (all components P<.001). Furthermore, 58.3% (14/24) reported subjective voice. Conclusions demonstrates that home-based, self-training delivered feasible solution suggesting can serve convenient effective alternative by enhancing accessibility empowering actively manage condition.

Language: Английский

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Short-term effects of “Yijinjing Wohu Pushi” posture-voice therapy on speech in Parkinson’s disease after STN-DBS

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 14, 2023

Abstract Hypokinetic dysarthria in Parkinson’s Disease (HD-PD) deteriorates patients’ quality of life by impeding communication and social engagement. Existing treatments like levodopa drugs deep brain stimulation (DBS) can improve motor symptoms but fall short addressing speech-related impairments; effective speech therapies tend not to mandate the posture, which potentially hinders vocal performance. Here we first proposed a therapeutic protocol that specified lunging-and-clawing posture (Wohu Pushi method from Yijinjing) during vocalization training. The aimed ensure PD patients could accomplish training even with moderate impairments. A total 20 HD-PD implanted stimulators subthalamic nuclei (STN-DBS) participated one session training, either following our posture-voice therapy (PVT) or conventional voice (CVT). Results indicated maximum phonation time was significantly elongated PVT(3.85±2.81s) CVT(0.46 ± 2.24s), formant-distance increased PVT(95.80 112.71Hz) compare CVT(-47.10 84.28Hz). Our results demanding appropriate amount postural maintenance vocalization, it might facilitate recovery functions. This study warranted larger-scale clinical trials understand impact, limitation, optimization for HD-PD.

Language: Английский

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Perceptual and qualitative voice alterations detected by GIRBAS in patients with Parkinson's disease: is there a relation with lung function and oxygenation?

Aging Clinical and Experimental Research, Journal Year: 2022, Volume and Issue: 35(3), P. 633 - 638

Published: Dec. 23, 2022

Language: Английский

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