Gut Microbes Reports,
Journal Year:
2024,
Volume and Issue:
1(1), P. 1 - 21
Published: Dec. 18, 2024
Clinical
studies
strongly
suggest
the
importance
of
diet
quality
on
cognition
in
youth
populations
(15-24
years).
The
Mediterranean
(MeDi)
has
been
shown
to
improve
contrast
commonly
consumed
Western
(WD).
gut
microbiota
may
serve
as
a
mechanism
for
diet-induced
changes
cognition.
Ten-week-old
male
Sprague
Dawley
rats
were
assigned
MeDi
or
WD
(n=10/group)
14
weeks.
Prior
neurobehavior
assessments,
community
composition
was
assessed.
At
genus
level,
relative
abundance
four
bacteria
increased
with
and
five
decreased
compared
WD.
Rats
group
demonstrated
cognitive
flexibility
improvement
reference
working
memory
group.
end
study,
serum
cytokines
increased,
low-density
lipoproteins
Markers
neuroinflammation,
blood-brain
barrier,
glial
cells,
synaptic
plasticity
brain
regions
did
not
differ
between
groups.
Overall,
modulated
microbiota,
function,
lipid
but
gene
expression
Further
are
needed
determine
causality
diet-modulated
immune
function.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(2)
Published: Nov. 22, 2023
Numerous
studies
have
described
the
notable
impact
of
gut
microbiota
on
brain
in
Alzheimer's
disease
(AD)
via
–
axis.
However,
molecular
mechanisms
underlying
involvement
development
AD
are
limited.
This
study
aimed
to
explore
potential
by
integrating
multi-omics
data.
In
this
study,
APP/PS1
and
WT
mice
at
nine
months
age
were
used
as
mouse
model.
Cognitive
function
was
assessed
using
Morris
water
maze
test.
The
levels
Aβ
plaque
neuroinflammation
detected
immunofluorescence
PET/CT.
addition,
we
not
only
16S
rRNA
gene
sequencing
metabolomics
variation
characteristics
serum
metabolism
abundance,
but
also
combined
spatial
transcriptomics
change
identify
their
correlation.
showed
significant
cognitive
impairment
amyloid-β
deposits
brain.
abundance
significantly
changed
mice,
including
decreased
Desulfoviobrio,
Enterococcus,
Turicibacter,
Ruminococcus
increased
Pseudomonas.
integration
untargeted
that
glycerophospholipid
a
common
alteration
pathway
mice.
Significant
proliferation
activation
astrocyte
microglia
observed
accompanied
alterations
immune
pathways.
Integration
analysis
fecal
transplantation
(FMT)
intervention
revealed
association
microbiota,
host
metabolism,
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(4), P. 833 - 845
Published: Aug. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
Microorganisms,
Journal Year:
2023,
Volume and Issue:
11(9), P. 2266 - 2266
Published: Sept. 9, 2023
Rikenella
microfusus
is
an
essential
intestinal
probiotic
with
great
potential.
The
latest
research
shows
that
imbalance
in
the
flora
are
related
to
occurrence
of
various
diseases,
such
as
immune
and
metabolic
diseases.
may
be
a
target
or
biomarker
for
some
providing
new
possibility
preventing
treating
these
diseases
by
monitoring
optimizing
abundance
intestine.
However,
current
methods
have
disadvantages,
long
detection
times,
complicated
operations,
high
costs,
which
seriously
limit
clinical
application
microbiome-based
treatment
options.
Therefore,
intention
this
study
was
evolve
enriched
aptamer
library
used
specific
labeling
R.
microfusus,
allowing
rapid
low-cost
and,
ultimately
construction
aptamer-based
biosensors.
In
study,
we
bacterium
vitro
whole
Cell-SELEX
(Systematic
Evolution
Ligands
EXponential
Enrichment)
enrich
DNA
oligonucleotide
aptamers.
Five
other
prominent
anaerobic
gut
bacteria
were
included
process
counterselection
served
control
cells.
R.m-R13
evolved
specificity
strong
affinity
(Kd
=
9.597
nM
after
13
rounds
selection).
With
library,
could
efficiently
discriminated
from
complex
mixtures
using
different
analysis
techniques,
including
fluorescence
microscopy
fluorometric
suspension
assays,
even
human
stool
samples.
These
preliminary
results
open
avenues
toward
development
microbiome
bio-sensing
applications
fast
reliable
microfusus.
Frontiers in Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: April 27, 2023
Being
isolated
from
the
peripheral
system
by
blood–brain
barrier,
brain
has
long
been
considered
a
completely
impervious
tissue.
However,
recent
findings
show
that
gut
microbiome
(GM)
influences
gastrointestinal
and
disorders
such
as
Alzheimer’s
disease
(AD).
Despite
several
hypotheses,
neuroinflammation,
tau
hyperphosphorylation,
amyloid
plaques,
neurofibrillary
tangles,
oxidative
stress,
being
proposed
to
explain
origin
progression
of
AD,
pathogenesis
remains
incompletely
understood.
Epigenetic,
molecular,
pathological
studies
suggest
GM
AD
development
have
endeavored
find
predictive,
sensitive,
non-invasive,
accurate
biomarkers
for
early
diagnosis
monitoring
progression.
Given
growing
interest
in
involvement
current
research
endeavors
identify
prospective
both
preclinical
clinical
diagnoses,
well
targeted
therapy
techniques.
Here,
we
discuss
most
on
changes
microbiome-based
biomarkers,
diagnostic
uses,
approaches.
Furthermore,
addressed
herbal
components,
which
could
provide
new
venue
research.
Environment International,
Journal Year:
2025,
Volume and Issue:
197, P. 109323 - 109323
Published: Feb. 7, 2025
Polystyrene
micro/nanoplastics
(MPs/NPs)
are
globally
recognized
environmental
concerns
due
to
their
widespread
pollution
and
detrimental
effects
on
physiological
functions.
However,
the
neurotoxic
underlying
mechanisms
of
MPs/NPs
brain
function
in
adolescents
remain
incompletely
understood.
This
study
investigated
polystyrene
neurobehavioral
adolescent
mice,
utilizing
multi-omic
analysis
molecular
biology
assays
explore
potential
mechanisms.
Following
oral
exposure
MPs
(5
μm)
or
NPs
(0.5
at
0.5
mg/day
for
4
weeks,
induced
more
severe
cognitive
impairment
mice
than
MPs,
as
assessed
by
Morris
water
maze
Y-maze
tests.
might
be
associated
with
neuron
loss
neurogenesis
inhibition
caused
NPs,
while
dendritic
spine
mediated
hippocampus.
Furthermore,
hippocampal
transcriptome
Western
blotting
indicated
involvement
PI3K/AKT
pathway
NPs-induced
neurotoxicity.
Meanwhile,
pronounced
disruptions
metabolome
gut
microbiota,
strong
correlations
were
observed
between
changes
metabolites
bacteria.
elucidated
toxicity
mechanism
inducing
providing
insights
into
toxicological
impacts
strategies
intervention.
Nature Microbiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 26, 2025
Abstract
Aging
is
accompanied
by
considerable
changes
in
the
gut
microbiome,
yet
molecular
mechanisms
driving
aging
and
role
of
microbiome
remain
unclear.
Here
we
combined
metagenomics,
transcriptomics
metabolomics
from
mice
with
metabolic
modelling
to
characterize
host–microbiome
interactions
during
aging.
Reconstructing
integrated
models
host
181
mouse
microorganisms,
show
a
complex
dependency
metabolism
on
known
previously
undescribed
microbial
interactions.
We
observed
pronounced
reduction
activity
within
reduced
beneficial
between
bacterial
species.
These
coincided
increased
systemic
inflammation
downregulation
essential
pathways,
particularly
nucleotide
metabolism,
predicted
rely
microbiota
critical
for
preserving
intestinal
barrier
function,
cellular
replication
homeostasis.
Our
results
elucidate
microbiome–host
that
potentially
influence
processes.
pathways
could
serve
as
future
targets
development
microbiome-based
anti-aging
therapies.
