Gut Microbiota Defined Epigenomes of Alzheimer’s and Parkinson’s Diseases Reveal Novel Targets for Therapy

Epigenomics, Journal Year: 2023, Volume and Issue: 16(1), P. 57 - 77

Published: Dec. 13, 2023

The origins of Alzheimer's disease (AD) and Parkinson's (PD) involve genetic mutations, epigenetic changes, neurotoxin exposure gut microbiota dysregulation. microbiota's dynamic composition its metabolites influence intestinal blood-brain barrier integrity, contributing to AD PD development. This review explores protein misfolding, aggregation links in pathogenesis. It also highlights the role a leaky microbiota-gut-brain axis promoting these diseases through inflammation-induced alterations. In addition, we investigate potential diet, probiotics transplantation for preventing treating via modifications, along with discussion related current challenges future considerations. These approaches offer promise translating research findings into practical clinical applications.

Language: Английский

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Mibianto: ultra-efficient online microbiome analysis through k-mer based metagenomics

Nucleic Acids Research, Journal Year: 2024, Volume and Issue: 52(W1), P. W407 - W414

Published: May 8, 2024

Quantifying microbiome species and composition from metagenomic assays is often challenging due to its time-consuming nature computational complexity. In Bioinformatics, k-mer-based approaches were long established expedite the analysis of large sequencing data are now widely used annotate data. We make use k-mer counting techniques for efficient accurate compositional microbiota whole metagenome sequencing. Mibianto solves this problem by operating directly on read files, without manual preprocessing or complete exchange. It handles diverse platforms, including short single-end, paired-end, technologies. Our sketch-based workflow significantly reduces volume transferred user server (up 99.59% size reduction) subsequently perform taxonomic profiling with enhanced efficiency privacy. offers functionality beyond quantification; it supports advanced community estimation, diversity, ordination, differential abundance analysis. tool aids in standardization workflows, thus supporting reproducibility scientific studies. adaptable small- large-scale experimental designs a user-friendly interface, making an invaluable both clinical research-oriented freely available need login at: https://www.ccb.uni-saarland.de/mibianto.

Language: Английский

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Associations between gut microbiota characteristics and non‐motor symptoms following pharmacological and surgical treatments in Parkinson's disease patients

Neurogastroenterology & Motility, Journal Year: 2024, Volume and Issue: 36(8)

Published: June 14, 2024

The gut microbiota has been implicated in Parkinson's disease (PD), with alterations observed microbial composition and reduced species richness, which may influence gastrointestinal symptoms PD patients. It remains to be determined whether the severity of correlates variations patients treated pharmacologically or subthalamic nucleus deep brain stimulation (STN-DBS) therapy. This study aims explore how these treatments affect PD, identifying specific differences associated each treatment modality.

Language: Английский

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Understanding activity of butyrate at a cellular level

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(8), P. 2323 - 2324

Published: Sept. 6, 2024

Language: Английский

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Combination therapy of phytonanomedicine and post-biotic for the management of Parkinson's disease.

PubMed, Journal Year: 2024, Volume and Issue: 23, P. 1234 - 1237

Published: Jan. 1, 2024

Language: Английский

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