A comparative study of goji berry and ashwagandha extracts effects on promoting neural stem cell proliferation and reducing neuronal cell death DOI

Yanming Zhang,

Gang Wang

Food & medicine homology., Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Hormesis determines lifespan DOI Creative Commons
Edward J. Calabrese,

Marc Nascarella,

Peter Pressman

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102181 - 102181

Published: Jan. 4, 2024

Language: Английский

Citations

36
Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors DOI Creative Commons
Rong Li,

Qingping Yi,

Jinsong Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 173, P. 116368 - 116368

Published: March 11, 2024

Paeonol, as one of the most abundant plant-derived polyphenols, has multiple bioactivities including anti-inflammatory, anti-tumor, and anti-cardiovascular diseases. Nevertheless, anti-aging effects related mechanisms paeonol are rarely reported. In this study, we found that significantly prolonged mean lifespan Caenorhabditis elegans (C. elegans) by 28.49% at a dose 200 μM. Moreover, promoted health C. increasing body bending pharyngeal pumping rates reducing lipofuscin accumulation level. Meanwhile, induced expression stress-related genes or proteins activating transcription factors DAF-16/FOXO, SKN-1/Nrf2, HSF-1, which in turn enhanced oxidative thermal stress tolerance. The mechanism behind effect occurred down-regulating insulin/IGF-1 signaling (IIS) pathway. Our findings shed new light on application for longevity promotion human health.

Language: Английский

Citations

9
Structure, sources, functional mechanisms, and applications of bioactive glycopeptides in food: a comprehensive review DOI
Dangfeng Wang,

Benyou Zhang,

Likun Ren

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: 157, P. 104899 - 104899

Published: Feb. 1, 2025

Language: Английский

Citations

1
Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis DOI Creative Commons
Yunhao Wu, Li Zhang,

Shengda Cao

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Aminoglycoside antibiotic-induced sensorineural hearing loss (SNHL) is a common sensory disorder that requires the development of prophylactic and therapeutic interventions. Lycium barbarum glycopeptide (LBGP) peptidoglycan isolated purified from polysaccharides exhibit significant anti-inflammatory, antioxidant, neuroprotective effects, but role LBGP in aminoglycoside-induced SNHL has not been well investigated. Here it shown can protect against neomycin-induced impairment alleviate oxidative stress mouse model. Moreover, further found inhibition tryptophan hydroxylase (Tph)-mediated serotonin (5-HT) biosynthesis plays key mechanism action treating loss. Systemic delivery 5-HT increased apoptosis cochlear hair cells spiral ganglion neurons, pharmacological Tph2 with P-chlorophenylalanine or knock down by AAV-ie-Tph2 effectively attenuated dysfunction. Collectively, these results provide promising strategy for prevention using natural plant extract which more available exhibits lower side effects compared other otoprotective drugs, identify as potential target treatment ototoxicity.

Language: Английский

Citations

1
Bioactive Components of Lycium barbarum and Deep-Processing Fermentation Products DOI Creative Commons
Xiao Qiang, Ting Xia,

Beibei Geng

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(24), P. 8044 - 8044

Published: Dec. 12, 2023

Lycium barbarum, a homology of medicine and food, contains many active ingredients including polysaccharides, polyphenol, betaine, carotenoids, which has health benefits economic value. The bioactive components in barbarum exhibit the effects antioxidation, immune regulation, hypoglycemic effects, vision improvement. Recently, development nutrition products been paid more attention with increase awareness. A variety nutrients wolfberry can be retained or increased using modern fermentation technology. Through fermentation, have better flavor function, meet needs market diversification. main related to include fruit wine, vinegar, lactic acid fermented beverage. In this review, mainly its deep-processing were summarized compared. It will provide reference for research healthy barbarum.

Language: Английский

Citations

18
Lycium barbarum glycopeptide ameliorates motor and visual deficits in autoimmune inflammatory diseases DOI
Li Xu, Lu Yang, Huiming Xu

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155610 - 155610

Published: April 16, 2024

Language: Английский

Citations

6
A review of Lycium barbarum polysaccharides: Extraction, purification, structural-property relationships, and bioactive molecular mechanisms DOI
Jiao Wang, Shifeng Li, Zhang Hua

et al.

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 544, P. 109230 - 109230

Published: Aug. 9, 2024

Language: Английский

Citations

5
Wolfberry (Lycium barbarum) glycopeptide attenuates dopaminergic neurons loss by inhibiting lipid peroxidation in Parkinson's disease DOI
Xiaomin Lin,

Meng Wang,

Xin Xiao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156275 - 156275

Published: Nov. 27, 2024

Language: Английский

Citations

4
A review of pharmacological mechanisms, challenges and prospects of macromolecular glycopeptides DOI
Ye Gao, Xiaoyi Chen, Jin‐Ao Duan

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140294 - 140294

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lycium barbarum extract improves brain and visual functions in mice models of Alzheimer's disease through activating WNT pathway DOI
Xiu Han,

Mengrong Zhang,

Yajing Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156523 - 156523

Published: Feb. 17, 2025

Language: Английский

Citations

0