Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China DOI Creative Commons
Decheng Li, Yunhe Wang, Shuai Guo

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 199, P. 112656 - 112656

Published: Dec. 18, 2024

Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts. We included participants aged ≥60 years from 2015 wave China Health and Retirement Longitudinal Study (CHARLS). was evaluated across cognitive, locomotion, psychological, sensory, vitality domains. Asymmetry weakness were measured using maximum value HGS. Logistic regression models employed to examine association individual combined groupings impairment (a total score ≥ 2 five domains). The potential non-linear relationship explored a restricted cubic spline (RCS) model. Of 4798 (median age 66.0 years, IQR 63.0-71.0 years; 56.9 % male), 35.2 had impairment. (OR = 1.26, 95 CI: 1.11-1.43) 2.09, 1.78-2.45) both independent risk factors for Notably, experiencing at even higher 2.47, 1.99-3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between status impairments specific domains, particularly locomotion. In contrast other it Weakness only group, rather than Both that highest There U-shaped an increased composite domain Assessing maintaining symmetry may have implications early identification individuals prevention related adverse outcomes.

Language: Английский

Bidirectional Association of Gut Microbiota-Derived Trimethylamine N-Oxide and its Precursors with Estimated Glomerular Filtration Rate: A Cross-Lagged Cohort Study DOI Creative Commons
Ruiheng Peng,

Peiying Tian,

Ying Lü

et al.

Journal of Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

It is unclear whether Trimethylamine N-oxide (TMAO) and its precursors are bidirectionally associated with kidney dysfunction. This study aims to investigate increased TMAO linked decreased eGFR reduced elevated precursors. Our consists of participants creatinine, TMAO, (choline, carnitine, betaine) repeatedly measured from Fuxin Rural Cohort. We utilized cross-lagged panel models (CLPM) assess the potential bidirectional associations eGFR. Age-(≥60 <60 years) sex-specified interaction effects were examined using multi-group CLPMs. Bonferroni method was applied for multiple comparison. Of 1746 (mean age 59.4 ± 9.3 years, 584 (33%) male), inversely related after two years (Cross-Lagged Coefficient, 95% CI: -0.030, -0.058 -0.002, P=0.035), negatively carnitine (-0.138, -0.198 -0.078, P<0.001). Subgroup analysis showed significant between baseline in individuals aged 60 older (-0.061, -0.107 -0.014, P=0.011), (-0.093, -0.164 -0.022, P=0.010), those under (-0.153, -0.226 -0.079, P<0.001), females (-0.154, -0.229 Additionally, nominally choline (0.092, 0.017 0.167, P=0.017) males (0.114, 0.015 0.213, P=0.025). Deceased serum level may be choline. Conversely, function. provides novel evidence that managing healthy function helps keep at optimal levels, while maintaining low levels reduces risk disease.

Language: Английский

Citations

0
Longitudinal association between handgrip strength and depressive symptoms in middle-aged and older Chinese adults: mediating role of functional limitation DOI Creative Commons
Yanchang Liu, Jinghang Cui, Xin Luo

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 18, 2025

The relationship between handgrip strength (HGS) at baseline and subsequent depressive symptoms among middle-aged older Chinese adults remains highly uncertain. This research endeavored to investigate the effect of functional limitation on association these two variables. A total 5,684 participants aged ≥45 years from China Longitudinal Study Health Retirement (CHARLS) were enrolled, using data 2015 2018 waves. Functional was evaluated based participants' self-reported basic activities daily living (BADL) instrumental (IADL). Logistic regression models utilized analyze HGS symptoms, bootstrap analysis performed explore potential mediating role limitation. After adjusting for confounders, an inverse correlation detected (B = -0.885, p < 0.001), a positive found 1.054, 0.001). mediated size through a*b -0.933 (BCa 95% CI: -1.224, -0.642). had significant impact 18.9% overall association. Among senior population, accounted connection symptoms. Interventions targeting enhancement muscle should be regarded as crucial elements maintaining physical function preventing

Language: Английский

Citations

0
The Mediating Role of Cognitive Function in the Association between Grip Strength and Depression among Chinese middle-aged and elderly adults: A Cross-Sectional Study DOI Creative Commons

Xinzheng Wang,

Guohao Yi,

Lifei Wu

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 8, 2024

Abstract Objective This study investigates the associations and mediating pathways between grip strength, cognitive function, depression in middle-aged elderly individuals China. Methods Utilizing data from 2011 China Health Retirement Longitudinal Study (CHARLS), we employed logistic regression mediation analysis to examine relationships factors depression, while adjusting for potential confounders. Results The included 6,841 participants, of whom 1,734 (25.35%) exhibited symptoms depression. Our findings indicate that weak strength is significantly associated with an increased risk (OR: 1.57, 95% CI: 1.32–1.87) among population. Conversely, good function was found be protective against 0.94, 0.93–0.95). revealed indirectly affects through accounting 9.4% total effect −0.008, -0.013, − 0.004). Specifically, abilities such as calculation, memory, orientation were identified significant mediators relationship Conclusion highlights adequate can mitigate association These insights provide valuable guidance clinical practitioners diagnosis management emphasizing importance assessing function.

Language: Английский

Citations

0
Association of handgrip strength asymmetry and weakness with cognitive function: a nationally representative cohort study DOI
You-You Zhang,

Rui Zhu,

Liru Ge

et al.

Maturitas, Journal Year: 2024, Volume and Issue: 187, P. 108057 - 108057

Published: June 20, 2024

Language: Английский

Citations

0
The relationship between asymmetrical grip strength criteria and fall incidence among middle-aged and older Chinese adults DOI
Yilin Wang,

Zhouyu Li,

Mei Li

et al.

European Geriatric Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: June 22, 2024

Language: Английский

Citations

0
Validity of handgrip strength for assessing cognition and psychotic symptoms in hospitalized patients with stable schizophrenia DOI Creative Commons

Jianlin Pu,

Binyou Wang, Yilin Wang

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0308133 - e0308133

Published: Sept. 26, 2024

Background and objectives A correlation between low handgrip strength (HGS), HGS asymmetry, cognitive performance has been demonstrated. However, it remains unclear whether is associated with psychotic symptoms asymmetry in hospitalized patients schizophrenia. This study aimed to investigate the validity of as a measure for assessing cognition stable Methods total 235 inpatients schizophrenia were recruited August 1, 2023, 31, 2023. The highest values from three tests on dominant hand used determine (male < 28 kg, female 18 kg), was identified when non-dominant HGS/dominant ratio outside 0.9–1.1. Cognition assessed using Chinese Montreal Cognitive Assessment (MoCA-C) Positive Negative Syndrome Scale (PANSS). Generalized linear model analyses examined relationship scale scores. Results Covariate-adjusted generalized models confirmed strong association alone MoCA-C score (OR = 0.819, 95% CI 0.710‒0.945, p 0.006) PANSS 1.113, 1.036‒1.239, 0.006). Similarly, combination asymmetric strongly both 0.748, 0.653‒0.857, p<0.001) scores 1.118, 1.032‒1.211, Conclusions results suggest that HGS, or without are likely have lower higher Screening could be valuable straightforward approach identifying those severe symptoms.

Language: Английский

Citations

0
Grip strength and depressive symptoms in Chinese middle-aged and older adults: the mediating effects of cognitive function DOI Creative Commons

Xinzheng Wang,

Lifei Wu,

Hui-Fen Zhou

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Oct. 9, 2024

Objective This study investigates the associations and mediating pathways between grip strength, cognitive function, depression in middle-aged elderly individuals China. Methods Utilizing data from 2011 China Health Retirement Longitudinal Study (CHARLS), we employed logistic regression mediation analysis to examine relationships factors depression, while adjusting for potential confounders. Results The included 6,841 participants, of whom 1,734 (25.35%) exhibited symptoms depression. Our findings indicate that weak strength is significantly associated with an increased risk (OR: 1.57, 95% CI: 1.32–1.87) among population. Conversely, good function was found be protective against 0.94, 0.93–0.95). Grip indirectly affected through accounting 9.4% total effect ( β = −0.008, CI [−0.013, −0.004]). 23.8% men −0.013, [−0.020, −0.007]); 23.2% those aged 60 years over −0.015, [−0.022, −0.009]). Conclusion highlights increases depressive symptoms, adequate can mitigate association Psychological care elder adults poor should strengthened.

Language: Английский

Citations

0
Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China DOI Creative Commons
Decheng Li, Yunhe Wang, Shuai Guo

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 199, P. 112656 - 112656

Published: Dec. 18, 2024

Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts. We included participants aged ≥60 years from 2015 wave China Health and Retirement Longitudinal Study (CHARLS). was evaluated across cognitive, locomotion, psychological, sensory, vitality domains. Asymmetry weakness were measured using maximum value HGS. Logistic regression models employed to examine association individual combined groupings impairment (a total score ≥ 2 five domains). The potential non-linear relationship explored a restricted cubic spline (RCS) model. Of 4798 (median age 66.0 years, IQR 63.0-71.0 years; 56.9 % male), 35.2 had impairment. (OR = 1.26, 95 CI: 1.11-1.43) 2.09, 1.78-2.45) both independent risk factors for Notably, experiencing at even higher 2.47, 1.99-3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between status impairments specific domains, particularly locomotion. In contrast other it Weakness only group, rather than Both that highest There U-shaped an increased composite domain Assessing maintaining symmetry may have implications early identification individuals prevention related adverse outcomes.

Language: Английский

Citations

0