Benha Journal of Applied Sciences,
Journal Year:
2023,
Volume and Issue:
8(8), P. 29 - 37
Published: Aug. 29, 2023
Background:
Vitiligo
is
an
acquired
autoimmune
disorder
characterized
by
patchy
depigmentation
in
the
skin
and
hair.Dysregulation
of
lipid
metabolism
immune
dysregulation
are
key
factors
pathogenesis
vitiligo.Apolipoprotein
E4
(ApoE4),
a
protein
involved
metabolism,
has
been
implicated
various
health
conditions.Assessing
serum
levels
ApoE4
patients
with
vitiligo
may
provide
insights
into
disease
process
clinical
implications.Objective:
The
review
aims
to
explore
potential
role
pathogenesis,
its
association
dysregulation,
implications
altered
levels.Conclusions:
In
conclusion,
assessment
Apolipoprotein
(ApoE4)
holds
promise
as
avenue
for
understanding
implications.
Advances in medical technologies and clinical practice book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 34
Published: Dec. 13, 2024
Pharmacogenomics
is
the
study
of
genetic
modifications
in
patients
that
influence
their
potential
to
metabolize
medications,
encouraging
tolerability
and
desired
effect.
Genetic
(like
genome-wide
association
&
candidate
gene)
methods
may
help
choosing
most
suitable
drug
dosage,
by
impeding
adverse
reactions
(ADRs).
are
usually
documented
as
key
steps
personalized
medicine.
The
significance
medicine
healthcare
developing
due
its
defined
molecular
basis.
Personalized
anticipates
beneficial
or
serious
side
effects
a
medication
using
specific
individual's
profile.
In
recent
year's
pharmacogenomics
approaches
being
widely
used
personalizing
therapies
for
diseases
like
Cancer,
Rheumatoid
arthritis,
Asthma,
Type-1
diabetes
many
psychiatric
disorders
(depression,
psychosis,
schizophrenia
etc.).This
chapter
provides
an
overview
present
importance
identifies
challenges
need
be
conquered
effective
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 11119 - 11119
Published: July 5, 2023
We
recently
developed
a
multiplex
diagnostic
kit,
QPLEX™
Alz
plus
assay
which
captures
amyloid-β1-40,
galectin-3
binding
protein,
angiotensin-converting
enzyme,
and
periostin
simultaneously
using
microliters
of
peripheral
blood
utilizes
an
optimized
algorithm
for
screening
Alzheimer’s
disease
(AD)
by
correlating
with
cerebral
amyloid
deposition.
Owing
to
the
demand
early
AD
detection,
we
investigate
potential
our
kit
clinical
diagnosis
AD.
A
total
1395
participants
were
recruited,
their
samples
analyzed
kit.
The
average
values
in
each
group
increased
gradually
order
progression
continuum
AD:
cognitively
normal
(0.382
±
0.150),
subjective
cognitive
decline
(0.452
0.130),
mild
impairment
(0.484
0.129),
(0.513
0.136).
between
showed
statistically
significant
differences
among
groups
divided
Mini-Mental
State
Examination
Clinical
Dementia
Rating.
could
be
used
distinguish
or
function.
Because
blood-based
is
more
accessible,
convenient,
cost-
time-effective
than
spinal
fluid
positron
emission
tomography
imaging-based
diagnosis,
can
potentially
health
checkups
Benha Journal of Applied Sciences,
Journal Year:
2023,
Volume and Issue:
8(8), P. 29 - 37
Published: Aug. 29, 2023
Background:
Vitiligo
is
an
acquired
autoimmune
disorder
characterized
by
patchy
depigmentation
in
the
skin
and
hair.Dysregulation
of
lipid
metabolism
immune
dysregulation
are
key
factors
pathogenesis
vitiligo.Apolipoprotein
E4
(ApoE4),
a
protein
involved
metabolism,
has
been
implicated
various
health
conditions.Assessing
serum
levels
ApoE4
patients
with
vitiligo
may
provide
insights
into
disease
process
clinical
implications.Objective:
The
review
aims
to
explore
potential
role
pathogenesis,
its
association
dysregulation,
implications
altered
levels.Conclusions:
In
conclusion,
assessment
Apolipoprotein
(ApoE4)
holds
promise
as
avenue
for
understanding
implications.
