An Exploratory Evaluation of a Tablet-based Tool to Detect Mild Cognitive Impairment in Older Adults (Preprint) DOI
Josephine McMurray, AnneMarie Levy,

W. S. Pang

et al.

Published: Jan. 29, 2024

BACKGROUND With the rapid aging of global population, prevalence mild cognitive impairment (MCI) and dementia is anticipated to surge worldwide. MCI serves as an intermediary stage between normal dementia, necessitating more sensitive effective screening tools for early identification intervention. The BrainFx SCREEN a novel digital tool designed assess impairment. This study evaluated its efficacy in primary care settings, particularly context population growing integration health solutions. OBJECTIVE objective was validity, reliability, applicability (hereafter, SCREEN) context. We conducted exploratory comparing with established tool, Quick Mild Cognitive Impairment (Qmci) screen. METHODS A concurrent mixed methods, prospective using quasi-experimental design 147 participants from 5 Family Health Teams (FHTs; characterized by multidisciplinary practice capitated funding) across southwestern Ontario, Canada. Participants included practitioners, patients, FHT administrative executives. Individuals aged ≥55 years no history or diagnosis rostered participating were eligible participate. screened both Qmci. also incorporated Geriatric Anxiety Scale–10 general anxiety levels at each screening. SCREEN’s scoring compared against that Qmci clinical judgment professionals. Statistical analyses sensitivity, specificity, internal consistency, test-retest reliability assessments. RESULTS found longer administration time complex algorithm, which proprietary unavailable independent analysis, presented challenges. Its indicated Cronbach α 0.63, below acceptable threshold. showed limitations, moderate intraclass correlation coefficient (0.54) inadequate κ (0.15) values. Sensitivity specificity consistent (63.25% 74.07%, respectively) cross-tabulation discrepant analysis. In addition, faced limitations due demographic skew (96/147, 65.3% female, well-educated participants), absence comprehensive <i>gold standard</i> diagnosis, financial constraints limiting inclusion confirmatory neuropsychological testing. CONCLUSIONS SCREEN, current form, does not meet necessary criteria optimal primarily lower reliability. As number technologies increases evolves, further testing refinement such are essential ensure their real-world settings. advocates continued research this rapidly advancing field better serve population. CLINICALTRIAL

INTERNATIONAL REGISTERED REPORT RR2-10.2196/25520

Language: Английский

Factors associated with mild cognitive impairment among Palestinian community-dwelling older adults: a cross-sectional study DOI Creative Commons
May Hamdan, Souzan Zidan,

Rania Abualhaija

et al.

Cogent Psychology, Journal Year: 2025, Volume and Issue: 12(1)

Published: March 20, 2025

Language: Английский

Citations

0
PENSIEVE-AI a brief cognitive test to detect cognitive impairment across diverse literacy DOI Creative Commons
Tau Ming Liew, Jong Yong Abdiel Foo, Howard H. Yang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 23, 2025

Undiagnosed cognitive impairment is a pervasive global issue, often due to subtle nature of early symptoms, necessitating the use brief tests for detection. However, most are not scalable (requiring trained professionals), and designed lower literacy groups (e.g. in underserved communities). Here, we developed PENSIEVE-AITM, drawing-based digital test that less dependent on literacy, can be self-administered <5 min. In prospective study involving 1758 community-dwelling individuals aged 65 older from Singapore (education range = 0–23 years), our deep-learning model showed excellent performance detecting clinically-adjudicated mild dementia (AUC 93%), comparable traditional neuropsychological assessments 94%, Pcomparison 1.000). Results were consistent even across education subgroups. Being PENSIEVE-AI holds promise broader deployment literacy-diverse populations similar some Asian lower- middle-income countries), potentially improving detection intervention impairment. drawing-based, It matches dementia, offering populations.

Language: Английский

Citations

0
Baseline Brain Volumes Predict Future Brain Atrophy in Mild Cognitive Impairment: A Tensor-based Morphometry Study of the Alzheimer Continuum DOI
Mehrdad Mozafar, Mobina Amanollahi, Mohammad Sadeghi

et al.

Journal of Computer Assisted Tomography, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Objective: Prognostic evaluation of patients with mild cognitive impairment (MCI) is great importance, and magnetic resonance imaging, as a readily available modality, can play pivotal role in this field. Methods: Using the Alzheimer Disease Neuroimaging Initiative database, we conducted retrospective longitudinal study associations between volumetric brain imaging composite scores all domains (memory, executive function, language, visuospatial) annual whole-brain atrophy based on tensor-based morphometry (TBM) among MCI healthy controls (HCs). The Reliable Change Index was further used to categorize into 2 groups including (1) meaningful 1-year reliable changes [reliable change (RC) group] (2) without (non-RC). Results: One hundred thirty-seven 132 HCs were enrolled. showed no significant differences age, sex, apolipoprotein E4 expression ( P > 0.05). Based TBM score, had more volume loss than < 0.001). After multiple comparison corrections, score positively correlated baseline whole = 0.03), hippocampus 0.0001), entorhinal middle temporal 0.0001) volumes patients, indicating that lower these regions associated greater rates. Regression analyses positive correlation memory rate 0.01, 0.04), demonstrating that lower greater rate. However, correlations longer held significance after correction for 0.05, 0.17). participants RCs language initially had significantly those 0.03, corrected 0.06). RC non-RC other Conclusions: Lower regions are with annual TBM, suggesting potential marker conventional studies MCI. Further research needed explore link application across disease spectrum.

Language: Английский

Citations

0
Longitudinal Trajectories of Cognitive Function Among Chinese Middle-Aged and Older Adults: The Role of Sarcopenia and Depressive Symptoms DOI Creative Commons
Shengxuan Jin, Jianqian Chao, Jin Qian

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 408 - 408

Published: April 17, 2025

Objectives: The longitudinal relationship between sarcopenia, depression, and cognitive impairment has been insufficiently studied in China. This study aimed to characterize the association sarcopenia mediating role of depression using nationally representative data. Methods: 7091 middle-aged older adults were analyzed from China Health Retirement Longitudinal Study (CHARLS) across three waves (2011, 2013, 2015). Cognitive trajectories modeled a group-based trajectory model (GBTM), while multivariable ordinal logistic regression was employed evaluate associations with trajectories. depressive symptoms assessed through bootstrap mediation analysis cross-lagged panel modeling (CLPM). Results: Trajectory identified four distinct function patterns: "High Stable" (n = 2563, 36.73%), "Middle group 2860, 38.76%), Decline" 1280, 18.62%), "Low 388, 5.90%). Sarcopenia associated [Overall: OR (95%CI) 0.315 (0.259, 0.382) 0.417 (0.380, 0.459)]. Mediation indicated that accounted for 11.78% demonstrated significant pathway "T1 → T2 T3 sarcopenia", 5.31% total effect. Conclusions: Our trajectories, significantly worse over time. Depressive mediated function. highlights importance integrating mental health physical interventions address interconnected risks aging.

Language: Английский

Citations

0
Prevalence of sarcopenia in middle-aged and older adults with cognitive impairment: a meta-analysis DOI
Jia‐You Ye,

Li‐Fang Chang,

Ruey Chen

et al.

Age and Ageing, Journal Year: 2025, Volume and Issue: 54(5)

Published: May 1, 2025

Cognitive impairment, dementia and sarcopenia significantly reduce the quality of life in middle-aged older adults by impairing daily functioning, making cognitive decline a major concern for healthcare professionals. To estimate prevalence probable with impairment. Six databases-Embase, Ovid MEDLINE, PubMed, CINAHL, Scopus Web Science was conducted through February 2025. Cohort cross-sectional studies included, random-effects model used pooled analysis. impairment is functions, including memory, attention executive function, covering mild dementia. Sarcopenia decreased skeletal muscle mass assessed strength or physical performance. A total 67 involving 23 532 participants revealed 30.1% 40.5%. Additionally, amongst aged 65 older, 32.7%. The varied setting: 25.3% community-dwelling populations, 35.5% hospitals 41.5% institutional settings. Moderating factors included age, female, body index, comorbidities risk such as depression, diabetes, hypertension, malnutrition, osteoarthritis, alcohol consumption smoking. Approximately one-third demonstrate to have sarcopenia. Early detection tailored interventions public health professionals are crucial, particularly individuals Enhanced preventive strategies essential improving outcomes reducing costs.

Language: Английский

Citations

0
The Silver Agri Age project in Italy: a Montessori-inspired social intervention with older adults with mild cognitive impairment. Single-group pre-post pilot study protocol DOI Creative Commons
Elena Gambella, Luigi Lombardi,

Diletta Cicconi

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 16, 2025

Introduction According to literature, an estimated percentage of 10–15% people diagnosed with Mild Cognitive Impairment each year develop Alzheimer’s dementia. Prevention and non-pharmacological treatments play important role in dealing this emergency. In regard, literature has highlighted how exposure nature, participation horticultural cognitive activities, adopting a Montessori approach are useful counteract decline promote well-being. Therefore, the Silver Agri Age pilot study will test Montessori-inspired social intervention that be carried out on farms Marche Region (Central Italy) authorized for agriculture aimed at older adult population mild impairment order improve their well-being quality life. This paper describes protocol main outcome. Methods Four involved three participating study, total 12 participants. The inclusion criteria age ≥ 55, Mini-Mental State Examination 24, ability willingness sign informed consent. evaluation focus assessment person’s emotional well-being, life quality, status. To evaluate feasibility project, participants’ engagement activities satisfaction subjects caregivers project also assessed. Discussion conclusion During three-month phase different farming proposed. Activities include sensory stimulation socialization within farm. Since according Montessori-based programs nature generate positive effects, participants assessed as primary outcome secondary Additionally, we believe promoting progressively challenging autonomy may help stabilize decline. level Ultimately, provide insights into possibility integrating prototype improving MCI dementia prevention service system. Clinical trial ClinicalTrials.gov Identifier: NCT06754202.

Language: Английский

Citations

0
Cognitive Frailty and Cardiometabolic Risk in Middle-Aged and Older Adults: Evidence from the UK and China DOI

Hai-Yang Yan,

Jingjing Lang,

Chengfeng Li

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Background: Cognitive frailty, a novel construct integrating cognitive and physical deficits, is increasingly recognized in aging research. Aims: This study aimed to examine the associations between frailty cardiometabolic risk two nationally representative cohorts from China United Kingdom. Methods: We analyzed data 7,628 participants Health Retirement Longitudinal Study (CHARLS) 4,703 English of Ageing (ELSA), all aged ≥50 years. Frailty was assessed using index (FI) main analysis. Cox proportional hazards models were applied estimate hazard ratios (HRs) for incident diseases (CMDs), cardiovascular (CVDs), diabetes. Subgroup interaction analyses performed effect modification. Restricted cubic spline (RCS) used assess shape association FI CMD among individuals with impairment. Sensitivity employed competing phenotype (PFP) as an alternative measure. Results: associated higher risks CMDs (HR 1.58, 95% CI 1.39–1.79), CVDs 1.64, 1.42–1.89), diabetes 1.39, 1.11–1.75). impairment alone showed no significant these outcomes. Significant dose–response observed Results consistent across robust sensitivity analyses. Conclusions: Cognitive predictor distinct populations, supporting integrated screening prevention strategies targeting both deficits populations.

Language: Английский

Citations

0
Development of audiometric parameters throughout the lifespan. II: Relationships between parameters DOI
Zbyněk Bureš, Jan Voráček,

Dora Čapková

et al.

Hearing Research, Journal Year: 2025, Volume and Issue: unknown, P. 109309 - 109309

Published: May 1, 2025

Language: Английский

Citations

0
Dose-response relationship of egg consumption with cognitive function in rural older adults: a large-scale population-based study DOI Creative Commons

Tingyun Ren,

Yinghao Yuchi, Shuo Feng

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 20, 2025

Background Previous studies had accessed the effect of egg consumption on cognitive function, but general population-based evidence is limited and inconclusive. In addition, optimal intake remains unclear. The study aimed to investigate association with mild impairment (MCI) in rural adults then explore recommended eggs. Methods This included 14,550 participants from second wave Henan Rural Cohort Study. Egg was assessed using a validated food frequency questionnaire. Cognitive function measured Mini-Mental State Examination (MMSE). MCI defined as MMSE scores ≤ 17 for illiteracy, 20 primary school education, or 24 junior high education higher. Logistic regression analyzed relationship between MCI. Dose-response relationships were evaluated restricted cubic spline (RCS) models. Results adjusted odds ratio ( OR ) 95% confidence interval CI per SD increase daily 0.925 (0.891, 0.960). A U-shape dose-response found p &lt; 0.001), 87.94 g/day. further analysis showed that (95%CI) below above (87.94 g/day) 0.826 (0.774, 0.880) 1.188 (1.056, 1.336), respectively. Sensitivity analyses similar results. Conclusion associated among populations eat g/day could have best benefit, supporting its potential role dietary strategies health.

Language: Английский

Citations

0
Cognitive Fitness: Harnessing the Strength of Exerkines for Aging and Metabolic Challenges DOI Creative Commons
Mona Saheli,

Mandana Moshrefi,

Masoumeh Baghalishahi

et al.

Sports, Journal Year: 2024, Volume and Issue: 12(2), P. 57 - 57

Published: Feb. 13, 2024

Addressing cognitive impairment (CI) represents a significant global challenge in health and social care. Evidence suggests that aging metabolic disorders increase the risk of CI, yet promisingly, physical exercise has been identified as potential ameliorative factor. Specifically, there is growing understanding exercise-induced improvement may be mediated by molecules known exerkines. This review delves into impact on elucidating mechanisms through which various exerkines bolster function this context. Additionally, discussion extends to role facilitating stem cell mobilization, offering avenue for improving impairment.

Language: Английский

Citations

2